Proposal for a Maturity Continuum Model for Open Research Data

As a contribution to the general effort in research to generalize and improve the practices of Open Research Data (ORD), we developed a model conceptualizing the degrees of maturity of a research community in terms of ORD. This model may be used to assess the ORD capacity or maturity level of a specific research community, to strengthen the use of standards with respect to ORD within this community, and to increase its ORD maturity level. We present the background and our motivations for developing such an instrument as well as the reasoning leading to its design. We present its elements in detail and discuss possible applications.&nbsp

Comprendre les comportements informationnels des étudiant.e.s dans un contexte Open ::approches croisées basées sur les pratiques

Les travaux et études consacrées aux comportements informationnels des étudiant(e)s portent souvent sur une évaluation des compétences en s’appuyant sur des enquêtes par questionnaires (Karsenti, Dumouchel, Komis 2014 ; Pochet, Thirion, 2015). L’approche basée sur les données (Evidence-Based Librarianship ou EBL, (Koufogiannakis, Brettle, 2016)) est peu développée dans les contextes francophones même si certaines bibliothèques commencent a la mettre en œuvre (Jullien Cottart, Touitou, 2021). Les statistiques existantes, parcellaires et imprécises, ne permettent pas de connaître précisément ces pratiques (Favre 2020), surtout dans un environnement de croissance de l’Open Science. En effet, elles ne mesurent pas la part des usages qui ne passent pas par elle, par exemple pour des ressources librement accessibles disponibles dans des dépôts institutionnels. Or, mieux comprendre les logiques et les mécanismes mis en œuvre dans les parcours de recherche documentaire des étudiant(e)s est essentiel a la redéfinition des écosystèmes documentaires académiques (Cordier, 2018). A l’origine de ces travaux figurent également deux sujets d’actualité importants dans le milieu académique, et plus particulièrement en Suisse : d’une part l’évolution du contexte Open Science avec la mise en place d’accords transformants (Van-Barneveld-Biesma et al., 2020) et d’autre part le passage à un accès aux ressources documentaires centralisé au niveau suisse via le projet SLSP (Swiss Library Service Platform)

Proposal for a maturity continuum model for open research data

As a contribution to the general effort in research to generalize and improve the practices of Open Research Data (ORD), we developed a model conceptualizing the degrees of maturity of a research community in terms of ORD. This model may be used to assess the ORD capacity or maturity level of a specific research community, to strengthen the use of standards with respect to ORD within this community, and to increase its ORD maturity level. We hereby present the background and our motivations for developing such an instrument as well as the reasoning leading to its design. We present its elements into detail and discuss possible applications

Les mondes agricoles face au problème des pesticides. Compromis, ajustements et négociations. Introduction au dossier

International audienc

Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases.

PURPOSE: Chimeric antigen receptor modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases (LM), a major cause of death in patients with gastrointestinal cancers, has yet to be achieved. We sought to test intrahepatic delivery of anti-CEA CAR-T through percutaneous hepatic artery infusions (HAI). EXPERIMENTAL DESIGN: We conducted a phase I trial to test HAI of CAR-T in patients with CEA+ LM. Six patients completed the protocol, and 3 received anti-CEA CAR-T HAIs alone in dose-escalation fashion (10(8), 10(9), and 10(10) cells). We treated an additional 3 patients with the maximum planned CAR-T HAI dose (10(10) cells X 3) along with systemic IL2 support. RESULTS: Four patients had more than 10 LM and patients received a mean of 2.5 lines of conventional systemic therapy prior to enrollment. No patient suffered a grade 3 or 4 adverse event related to the CAR-T HAIs. One patient remains alive with stable disease at 23 months following CAR-T HAI and 5 patients died of progressive disease. Among the patients in the cohort that received systemic IL2 support, CEA levels decreased 37% (range 19–48%) from baseline. Biopsies demonstrated an increase in LM necrosis or fibrosis in 4 of 6 patients. Elevated serum IFNγ levels correlated with IL2 administration and CEA decreases. CONCLUSIONS: We have demonstrated the safety of anti-CEA CAR-T HAIs with encouraging signals of clinical activity in a heavily pre-treated population with large tumor burdens. Further clinical testing of CAR-T HAIs for LM is warranted