Can DMD obtain a scene background in color?

A background model describes a scene without any foreground objects and has a number of applications, ranging from video surveillance to computational photography. Recent studies have introduced the method of Dynamic Mode Decomposition (DMD) for robustly separating video frames into a background model and foreground components. While the method introduced operates by converting color images to grayscale, we in this study propose a technique to obtain the background model in the color domain. The effectiveness of our technique is demonstrated using a publicly available Scene Background Initialisation (SBI) dataset. Our results both qualitatively and quantitatively show that DMD can successfully obtain a colored background model

Antiviral activity of silymarin in comparison with baicalein against EV-A71

Background: The hand, foot and mouth disease (HFMD) is a febrile and exanthematous childhood disease mainly caused by Enterovirus 71 (EV-A71). In severe HFMD, virulent EV-A71 strains can cause acute flaccid paralysis and cardiopulmonary edema leading to death. Currently, no FDA approved antiviral treatment or vaccine is available for EV-A71. Flavonoids such as silymarin and baicalein are known to possess in vitro antiviral properties against viruses. In this study, the cytotoxicity and antiviral activity of silymarin, baicalein and baicalin were investigated. Methods: The cytotoxic effects of three flavonoids towards rhabdomyosarcoma (RD) cells were first examined using cell proliferation MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay. Compounds found to be non-cytotoxic in RD cells were evaluated for their in vitro antiviral properties against the EVA71 subgenotype B4 strain 41 (5865/SIN/000009) using antiviral assays. Viral infectivity was determined by reduction of the formation of plaques in RD cells. For the measurement of RNA copy number, the real time quantitative reverse transcription PCR (qRT-PCR) was used. The most potent compound was further evaluated to determine the mode of action of inhibition by time course, virus attachment and entry assays in Vero cells. Results: Silymarin was shown to exert direct extracellular virucidal effects against EV-A71 at 50% inhibitory concentration (IC50) of 15.2 ± 3.53 μg/mL with SI of 10.53. Similarly, baicalein exhibited direct extracellular virucidal effects against EV-A71 at a higher IC50 value of 30.88 ± 5.50 μg/mL with SI of 13.64. Besides virucidal activity, silymarin was shown to block both viral attachment and entry of EV-A71 to inhibit infection in Vero cells. Conclusions: Silymarin has a stronger inhibition activity against EV-A71 in comparison to baicalein. It could serve as a promising antiviral drug to treat EV-A71 infections

Structure-based design of antivirals against Envelope Glycoprotein of dengue virus

Dengue virus (DENV) presents a significant threat to global public health with more than 500,000 hospitalizations and 25,000 deaths annually. Currently, there is no clinically approved antiviral drug to treat DENV infection. The envelope (E) glycoprotein of DENV is a promising target for drug discovery as the E protein is important for viral attachment and fusion. Understanding the structure and function of DENV E protein has led to the exploration of structure-based drug discovery of antiviral compounds and peptides against DENV infections. This review summarizes the structural information of the DENV E protein with regards to DENV attachment and fusion. The information enables the development of antiviral agents through structure-based approaches. In addition, this review compares the potency of antivirals targeting the E protein with the antivirals targeting DENV multifunctional enzymes, repurposed drugs and clinically approved antiviral drugs. None of the current DENV antiviral candidates possess potency similar to the approved antiviral drugs which indicates that more efforts and resources must be invested before an effective DENV drug materializes

Movement correction in DCE-MRI through windowed and reconstruction dynamic mode decomposition

Images of the kidneys using dynamic contrast enhanced magnetic resonance renography (DCE-MRR) contains unwanted complex organ motion due to respiration. This gives rise to motion artefacts that hinder the clinical assessment of kidney function. However, due to the rapid change in contrast agent within the DCE-MR image sequence, commonly used intensity-based image registration techniques are likely to fail. While semi-automated approaches involving human experts are a possible alternative, they pose significant drawbacks including inter-observer variability, and the bottleneck introduced through manual inspection of the multiplicity of images produced during a DCE-MRR study. To address this issue, we present a novel automated, registration-free movement correction approach based on windowed and reconstruction variants of dynamic mode decomposition (WR-DMD). Our proposed method is validated on ten different healthy volunteers’ kidney DCEMRI data sets. The results, using block-matching-block evaluation on the image sequence produced by WR-DMD, show the elimination of 99% of mean motion magnitude when compared to the original data sets, thereby demonstrating the viability of automatic movement correction using WR-DMD

Advanced Control Architectures for Intelligent MicroGrids, Part I:Decentralized and Hierarchical Control

This paper presents a review of advanced control techniques for microgrids. This paper covers decentralized, distributed, and hierarchical control of grid-connected and islanded microgrids. At first, decentralized control techniques for microgrids are reviewed. Then, the recent developments in the stability analysis of decentralized controlled microgrids are discussed. Finally, hierarchical control for microgrids that mimic the behavior of the mains grid is reviewed

Determinants of the use of family planning methods among rural women in Plateau state, Nigeria

This study aimed at determining the factors that influence family planning practice among rural women of Pankshin district in Plateau state, Nigeria. A cross-sectional study using a simple random sampling method was conducted from October to December 2019. A self-administered questionnaire was used for data collection among 302 respondents. Among respondents, 48.3% had practised family planning and the most popular family planning method ever practised was injectables (57.5%). The determinants of family planning practice were age group 29-39 and 40-49 years old (AOR=4.373, p<0.001; AOR=5.862, p<0.001), discussion with partner (AOR=9.192, p<0.001) and partner’s approval (AOR=2.791, p=0.007). Findings showed an encouraging family planning prevalence with the main determinants involving male partners. Further efforts need to be made to promote family planning practice among male partners and to empower women of all reproductive age groups by providing them with relevant information that is needed for them to make informed decisions

Spider Haiku

The utilization of lightweight oil palm shell to produce high strength lightweight sustainable material has led many researchers towards its commercialization as structural concrete. However, the low tensile strength of Oil Palm Shell Concrete (OPSC) has hindered its development. This study aims to enhance the mechanical properties and flexural behaviours of OPSC by the addition of steel fibres of up to 3% by volume, to produce oil palm shell fibre-reinforced concrete (OPSFRC). The experimental results showed that the steel fibres significantly enhanced the mechanical properties of OPSFRC. The highest compressive strength, splitting tensile and flexural strengths of 55, 11.0 and 18.5 MPa, respectively, were achieved in the OPSFRC mix reinforced with 3% steel fibres. In addition, the flexural beam testing on OPSFRC beams with 3% steel fibres showed that the steel fibre reinforcement up to 3% produced notable increments in the moment capacity and crack resistance of OPSFRC beams, but accompanied by reduction in the ductility

J Interpers Violence

Homicide-suicide incidents involving child victims can have a detrimental impact on survivors of the violence, family members and friends of the decedents, and other community members, but the rare occurrence of these acts makes using quantitative data to examine their associated antecedents challenging. Therefore, using qualitative data from the 2003-2011 National Violent Death Reporting System, we examined 175 cases of homicide-suicide involving child victims in an effort to better understand the complex situational factors of these events. Our findings indicate that 98% of homicide-suicides with child victims are perpetrated by adults (mostly parents) and propelled by the perpetrators' intimate partner problems, mental health problems, and criminal/legal problems. These events are often premeditated, and plans for the violence are sometimes disclosed prior to its occurrence. Findings provide support for several theoretical perspectives, and implications for prevention are discussed.CC999999/Intramural CDC HHS/United States2019-02-01T00:00:00Z26385898PMC4795978vault:1634