Evaluation of quality level in managing the development of industrial enterprises

The research focuses on the substantiation of theoretical aspects and practical support for assessing the quality level of managing enterprises development taking into account the influence of the external and internal environment. The conceptual apparatus for estimation of quality development of enterprise management was refined, which makes it possible to determine reasonably the level of management according to the generally known elements (economic, social and ecological) that are proposed to be supplemented with an energy component. A new conceptual approach to the procedure of evaluation of the quality of development management by levels, the stages of which are proposed to expand by: the formation of the database by levels of management (state, regional), choice and evaluation of indicators by components of development and spheres of activity, development of the tools for management improvement. The integrated indicator has been proposed, which differs from the existing ones by the fact that it estimates the quality of development management, rather than the development level. In contrast to the previously proposed ones, the integrated indicator takes into account the influence of external environment by the components of development and of the internal environment – by the areas of activity for each component. That is why it has practical significance, since it allows performing monitoring and detecting the negative influence of management on the enterprise development. Taking coke plants as an example, the structures of the indicators that characterize the management quality were determined. A large number of indicators were reduced by the method of expert assessments, which increases the validity of the choice. Indicator estimates were constructed solely based on relative indicators (indices), which improves consistency. Using the integrated method, the estimation of the indicators by individual components and on the whole was performed. The scale for evaluation of the quality level of enterprise development management was constructed using the Harrington function. The new approach to assessing the quality of the enterprise development management and a complex of mathematical support will lead to the uniform economic, social, environmental and energy development of enterprises.Роботу присвячено обґрунтуванню теоретичних аспектiв та практичного забезпечення оцiнки якiсного рiвня управлiння розвитком пiдприємств з урахуванням впливу зовнiшнього та внутрiшнього середовища. Уточнено понятiйний апарат щодо оцiнки якiсного розвитку управлiння пiдприємствами, який дозволяє обґрунтовано визначати рiвень управлiння за загальновiдомими складовими (економiчної, соцiальної та екологiчної), до яких запропоновано додати енергетичну складову. Побудовано новий концептуальний пiдхiд до процедури оцiнки якостi управлiння розвитком за рiвнями, етапи якої запропоновано розширити за: формуванням бази даних за рiвнями управлiння (державний, регiональний), вибiр та оцiнка iндикаторiв за складовими розвитку та сферами дiяльностi, розробка iнструментiв щодо покращення управлiння. Запропоновано iнтегральний показника, який вiдрiзняється вiд iснуючих тим, що оцiнює якiсть управлiння розвитком, а не рiвень розвитку. На вiдмiну вiд запропонованих ранiше iнтегральний показник враховує вплив зовнiшнього середовища за складовими розвитку та внутрiшнього – за сферами дiяльностi по кожнiй складовiй. Тому, має практичну значимiсть, оскiльки стає можливим проводити монiторинг та виявляти негативний вплив управлiння на розвиток пiдприємства. На прикладi коксохiмiчних пiдприємств визначено склад iндикаторiв, якi характеризують якiсть управлiння. Велику кiлькiсть iндикаторiв скорочено за допомогою методу експертних оцiнок, що пiдвищує обґрунтованiсть вибору. Iндикаторнi оцiнки побудовано виключно за вiдносними показниками (iндексами), що покращує узгодженiсть. За iнтегральним методом проведена оцiнка iндикаторiв за окремими складовими та у цiлому. За функцiєю Харрiнгтону побудовано шкалу оцiнки якiсного рiвня управлiння розвитком пiдприємств. Новий пiдхiд щодо оцiнки якостi управлiння розвитком пiдприємств та комплекс математичного забезпечення приведе до рiвномiрного економiчного, соцiального, екологiчного i енергетичного розвитку пiдприємств

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells

The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined. In this study, we found that rifampicin, an agonist of human PXR, induced lipid accumulation in HepG2 cells. Lipid analysis showed the total cholesterol level increased. However, the free cholesterol and triglyceride levels were not changed. Treatment of HepG2 cells with rifampicin induced the expression of the free fatty acid transporter CD36 and ABCG1, as well as several lipogenic enzymes, including stearoyl-CoA desaturase-1 (SCD1), long chain free fatty acid elongase (FAE), and lecithin-cholesterol acyltransferase (LCAT), while the expression of acyl:cholesterol acetyltransferase(ACAT1) was not affected. Moreover, in PXR over-expressing HepG2 cells (HepG2-PXR), the SCD1 expression was significantly higher than in HepG2-Vector cells, even in the absence of rifampicin. Down-regulation of PXR by shRNA abolished the rifampicin-induced SCD1 gene expression in HepG2 cells. Promoter analysis showed that the human SCD1 gene promoter is activated by PXR and a novel DR-7 type PXR response element (PXRE) response element was located at -338 bp of the SCD1 gene promoter. Taken together, these results indicated that PXR activation promoted lipid synthesis in HepG2 cells and SCD1 is a novel PXR target gene. © 2013 Zhang et al

Problems of the implementation of economic rights of internally displaced person

Hlibko S., Rozghon O., Podrez-Riapolova I. (2022). Problems of the implementation of economic rights of internally displaced person. Law and innovative society, 1 (18),10-21. DOI: https://doi.org/10.37772/2309-9275-2022-1(18)-1. URL: https://apir.org.ua/index.php/lais/article/view/348/322In the conditions of martial law on the territory of Ukraine there is a need to develop an effective mechanism for exercising the rights of internally displaced persons. The problems of exercising economic rights, in particular, the problems in the field of realization of property rights by internally displaced persons, become especially relevant. The purpose of this article is to analyze research and the main provisions of regulations and draft laws relating to the implementation of economic rights of internally displaced persons. In the framework of this study, an analysis of the state of regulatory regulation of legal relations on selected topics. The existence of problems with the implementation of the Law of Ukraine «On Ensuring the Rights and Freedoms of Internally Displaced Persons» in the field of protection of property rights was identified, their importance and relevance were emphasized. It is established that the legislation of Ukraine in the field of legal regulation of property relations with the participation of internally displaced persons needs to be improved and appropriate changes made that will provide protection and additional guarantees for the exercise of property rights. In addition, the need to stimulate the realization of entrepreneurial and innovative potential was emphasized

Managing Costs of an Industrial Enterprise When Using Secondary Resources

Cost price reduction is one of the ways to improve the competitiveness of products. It is possible by establishing the set of factors affecting the production costs at an industrial enterprise and building on this basis a mathematical model of in-house cost management.The study objective was to develop and substantiate an economic-and-mathematical model of management to minimize the enterprise costs taking into account the utilization of secondary resources obtained in the production of basic products. The model consists of two stages. At the first stage, full costs of production of basic and additional products are determined. The peculiarity of this production implies the generation of significant amounts of secondary resources that have both independent value and opportunities for their use in the main technological process. This leads to complex material flows within the production process, which were accounted for in the study with the help of an adapted "cost-output" balance model.A plant can function with the use of a variety of raw materials which differ in both prices and rates of the output of basic products and secondary resources. This brings about the problem of finding an optimal combination of input resources to minimize costs or maximize profits. The problem is solved in the second stage. It is formalized as a linear programming problem. It features the provision of the ability to establish indicative plans of production of both main products and by-products.The model was tested on the example of coke-chemical plants producing coke of KDM-2 grade with 6 % humidity content and KDM-1 grade coke of improved quality as the main products. Coke oven gas, coke fines, beans, and sludge are produced as by-products. After purifying the coke oven gas, it is further used in the production of heat and electricity, compressed air, and a fuel for coke ovens. Thus, the produced fuel and energy, utilizable material resources, and circulating water supply are secondary resources. A certain portion of by-products is sold to third parties.When applied, the model will make it possible to improve the efficiency of cost management at enterprise

Managing Costs of an Industrial Enterprise When Using Secondary Resources

Cost price reduction is one of the ways to improve the competitiveness of products. It is possible by establishing the set of factors affecting the production costs at an industrial enterprise and building on this basis a mathematical model of in-house cost management.The study objective was to develop and substantiate an economic-and-mathematical model of management to minimize the enterprise costs taking into account the utilization of secondary resources obtained in the production of basic products. The model consists of two stages. At the first stage, full costs of production of basic and additional products are determined. The peculiarity of this production implies the generation of significant amounts of secondary resources that have both independent value and opportunities for their use in the main technological process. This leads to complex material flows within the production process, which were accounted for in the study with the help of an adapted "cost-output" balance model.A plant can function with the use of a variety of raw materials which differ in both prices and rates of the output of basic products and secondary resources. This brings about the problem of finding an optimal combination of input resources to minimize costs or maximize profits. The problem is solved in the second stage. It is formalized as a linear programming problem. It features the provision of the ability to establish indicative plans of production of both main products and by-products.The model was tested on the example of coke-chemical plants producing coke of KDM-2 grade with 6 % humidity content and KDM-1 grade coke of improved quality as the main products. Coke oven gas, coke fines, beans, and sludge are produced as by-products. After purifying the coke oven gas, it is further used in the production of heat and electricity, compressed air, and a fuel for coke ovens. Thus, the produced fuel and energy, utilizable material resources, and circulating water supply are secondary resources. A certain portion of by-products is sold to third parties.When applied, the model will make it possible to improve the efficiency of cost management at enterprise

Development of Scientific and Methodological Approach to Quantitative and Qualitative Assessment of Intellectual Property Management in Industrial Enterprises

The competitiveness, market value and income of an enterprise depend on the level of intellectual property management. Therefore, the aim of research is to develop, substantiate and test a scientific and methodological approach to a quantitative and qualitative assessment of the management of intellectual property of industrial enterprises. The originality of the proposed approach is that on the basis of the concept of "management of intellectual property" a procedure for current management has been developed, the main stage of which is a quantitative and qualitative assessment. The assessment is based on the structural and logical model, which is built according to two criteria. The criteria make it possible to determine the current state of the use of intellectual property (intangible assets) – a quantitative assessment, and the prospect of further use (intellectual potential) – a qualitative assessment. A quantitative assessment involves the calculation of indicators characterizing the state of assets, the dynamics of the impact on the market value of the enterprise, the profitability of production, which is proposed to be determined through the net cash flow from operating activities. A qualitative assessment is carried out in terms of components (information and investment, organizational and legal, economic, personnel and motivation), tools and relative indicators that characterize the intellectual potential of an industrial enterprise. The assessment is carried out using a general integral indicator, which is of practical importance, since it shows the existing level of intellectual property management and directions for improvement in the future. The approbation of the scientific and methodological approach was carried out on the example of three Ukrainian coke-chemical enterprises (CJSC Avdeevka Coke Plant, CJSC Zaporozhkoks, CJSC Yuzhkoks) of the American association SUNCOKE ENERGY, INC and the Polish association J.S.W. S.A. Group. Empirical studies for the period from 2015 to 2019 made it possible to build a scale for assessing the level of intellectual property management according to the Harrington functio