CTCs-derived xenograft development in a Triple Negative breast cancer case

Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and no available molecular targets. CTCs derived xenografts (CDX) have demonstrated to be a promising tool for understanding cancer biology. In our study, a CDX from a TNBC patient was developed for the first time. After CDX characterization, WNT signaling was found as the main mechanism related with this tumor biology and potential CTCs markers were identified and subsequently validated in TNBC patients. In this cohort high levels of MELK expression were associated with poorer survival rates. Overall, our study demonstrates that CTCs from TNBC are tumorigenic and CDXs are a useful model to obtain valuable information about the tumor

What is the value of orthodontic treatment?

Orthodontic treatment is as popular as ever. Orthodontists frequently have long lists of people wanting treatment and the cost to the NHS in England was £258m in 2010-2011 (approximately 10% of the NHS annual spend on dentistry). It is important that clinicians and healthcare commissioners constantly question the contribution of interventions towards improving the health of the population. In this article, the authors outline some of the evidence for and against the claims that people with a malocclusion are at a disadvantage compared with those without a malocclusion and that orthodontic treatment has significant health benefits. The authors would like to point out that this is not a comprehensive and systematic review of the entire scientific literature. Rather the evidence is presented in order to stimulate discussion and debate

Reducing the health disparities of Indigenous Australians: time to change focus

Background: Indigenous peoples have worse health than non-Indigenous, are over-represented amongst the poor and disadvantaged, have lower life expectancies, and success in improving disparities is limited. To address this, research usually focuses on disadvantaged and marginalised groups, offering only partial understanding of influences underpinning slow progress. Critical analysis is also required of those with the power to perpetuate or improve health inequities. In this paper, using Australia as a case example, we explore the effects of ‘White’, Anglo-Australian cultural dominance in health service delivery to Indigenous Australians. We address the issue using race as an organising principle, underpinned by relations of power.Methods: Interviews with non-Indigenous medical practitioners in Western Australia with extensive experience in Indigenous health encouraged reflection and articulation of their insights into factors promoting or impeding quality health care to Indigenous Australians. Interviews were audio-taped and transcribed. An inductive, exploratory analysis identified key themes that were reviewed and interrogated in light of existing literature on health care to Indigenous people, race and disadvantage. The researchers’ past experience, knowledge and understanding of health care and Indigenous health assisted with data interpretation. Informal discussions were also held with colleagues working professionally in Indigenous policy, practice and community settings.Results: Racism emerged as a key issue, leading us to more deeply interrogate the role ‘Whiteness’ plays in Indigenous health care. While Whiteness can refer to skin colour, it also represents a racialized social structure where Indigenous knowledge, beliefs and values are subjugated to the dominant western biomedical model in policy and practice. Racism towards Indigenous patients in health services was institutional and interpersonal. Internalised racism was manifest when Indigenous patients incorporated racist attitudes and beliefs into their lived experience, lowering expectations and their sense of self-worth.Conclusions: Current health policies and practices favour standardised care where the voice of those who are marginalised is often absent. Examining the effectiveness of such models in reducing health disparities requires health providers to critically reflect on whether policies and practices promote or compromise Indigenous health and wellbeing - an important step in changing the discourse that places Indigenous people at the centre of the problem

B/Sub 4/C Absorber Pin in-Reactor Rupture Test

The results of rupture tests on prototypic FFTF B/sub 4/C absorber pins are presented. The test in EBR-2 involved an instrumented reference pin and a sealed pin. The observed behavior was compared with calculations by several computer models

Developing and Implementing a Community Empowerment Center to Build Local Capacity for Community-level Change

Background: Health disparities research is increasingly influenced by two paradigms: community-based participatory research (CBPR) and social determinants of health (SDOH). CBPR calls for collaborative research relationships that empower communities to co-generate research programs while SDOH perspectives focus on macro-level, “upstream” factors influencing health. The purpose of this study was to utilize a CBPR approach to address SDOH among residents of a public-housing community and adjacent neighborhood in Columbia, SC. Methods: A mini-grant program was developed to encourage community members to develop community-level, community-engaged interventions focused on creating a healthier environment. A six-session training program guided community members in proposal development, with 25 individuals attending at least one session. Results: Six proposals were submitted for external peer-review. Proposals were scored according to the degree of widespread community benefit, effective community engagement, and feasibility of implementation within a 6-month timeframe. Submitted proposals focused on food security (n=2), exercise (n=1), computer literacy (n=2), and community advocacy (n=2). The three awarded interventions focused on food security, exercise, and community advocacy. Each awardee team received $12,000 for implementation over six months. Additionally, a community garden was implemented in the community. The four interventions were evaluated collectively using a quasi-experimental design to assess their ability to increase community participation among residents. Conclusions: Community-generated, community-level, and community-engaged interventions provide community members with opportunities to address neighborhood concerns within a locale-specific context. The findings provide guidance for engaging community members in the development of community level interventions