347 research outputs found

    Syndecan-3 adds a Notch to its belt

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    Personalidad y valores interpersonales en estudiantes de psicología en una universidad privada de Trujillo

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    Para la presente investigación se analizó la relación entre la personalidad y los valores interpersonales en una muestra de 442 estudiantes de psicología de una Universidad Privada de la ciudad de Trujillo, a quienes se les aplicó el Cuestionario de Personalidad “Big Five” (BFQ) y el Cuestionario de Valores Interpersonales de Gordon (SIV). La investigación es Descriptiva- correlacional y se empleó el muestreo probabilístico aleatorio estratificado con distribución proporcional, usando como criterio de estratificación el género y el ciclo de estudios de la escuela académico profesional de psicología a la que pertenecían los estudiantes. Los resultados indican que existe una relación débil entre la Personalidad y los Valores Interpersonales; la dimensión energía se relaciona con el Valor Interpersonal de Liderazgo; la dimensión Afabilidad con los Valores Interpersonales de Benevolencia, Reconocimiento, Independencia y Liderazgo; la dimensión Tesón con los Valores Interpersonales de Conformidad, Independencia, Reconocimiento y Benevolencia; la dimensión Apertura Mental con los Valores Interpersonales de Benevolencia, Liderazgo y Reconocimiento; y la dimensión Estabilidad Emocional no se relaciona con ninguno de los Valores Interpersonales.For the present investigation there was analized the relationship between Personality and Interpersonal Values in a sample of 442 psychology students at a Private University in the city of Trujillo, who were applied the Big Five Personality Questionnaire (BFQ) and the Survey of Interpersonal Values of Gordon (SIV). The research is descriptive - correlational and there was used a stratified random probability sampling with proportional distribution using gender as stratification criteria and the academic cycle of the faculty of Psychology to which students belonged. The results indicate that there is a relationship between Personality and Interpersonal Values; Energy dimension relates to the Leadership value; Agreeableness dimension relates to the Benevolence, Recognition, Independence and Leadership values; the Teson dimension with Conformity, Independence, Recognition and Benevolence; Broadmindedness dimension with the Benevolence, Leadership and Recognition values; and Mental Stability dimension doesn´t relate to any Interpersonal Values

    Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling

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    Satellite cells (SCs) are skeletal muscle stem cells residing quiescent around healthy muscle fibres. In response to injury or disease SCs activate, proliferate and eventually differentiate and fuse to one another to form new muscle fibres, or to existing damaged fibres to repair them. The sulfated polysaccharide heparan sulfate (HS) is a highly variable biomolecule known to play key roles in the regulation of cell fate decisions, though the changes that muscle HS undergoes during SC differentiation are unknown. Here we show that the sulfation levels of HS increase during SC differentiation; more specifically, we observe an increase in 6-O and 2-O-sulfation in N-acetylated disaccharides. Interestingly, a specific increase in 6-O sulfation is also observed in the heparanome of ageing muscle, which we show leads to promotion of FGF2 signalling and satellite cell proliferation, suggesting a role for the heparanome dynamics in age-associated loss of quiescence. Addition of HS mimetics to differentiating SC cultures results in differential effects: an oversulfated HS mimetic increases differentiation and inhibits FGF2 signalling, a known major promoter of SC proliferation and inhibitor of differentiation. In contrast, FGF2 signalling is promoted by an N-acetylated HS mimetic, which inhibits differentiation and promotes SC expansion. We conclude that the heparanome of SCs is dynamically regulated during muscle differentiation and ageing, and that such changes might account for some of the phenotypes and signalling events that are associated with these processes

    Seismic Q estimates in Umbria-Marche (central Italy): hints for the retrieval of a new attenuation law for seismic risk

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    In the Umbria Marche (Central Italy) region an important earthquake sequence occurred in 1997, characterized by nine earthquakes with magnitudes in the range between 5 and 6, that caused important damages and causalities. In the present paper we separately estimate intrinsic- and scattering- Q −1 parameters, using the classical MLTWA approach in the assumption of a half space model. The results clearly show that the attenuation parameters Qi −1 and Qs −1 are frequency dependent. This estimate is compared with other attenuation studies carried out in the same area, and with all the other MLTWA estimates obtained till now in other tectonic environments in the Earth. The bias introduced by the half space assumption is investigated through numerical solutions of the Energy Transport equation in the more realistic assumption of a heterogeneous crust overlying a transparent mantle, with a Moho located at a depth ranging between 35 and 45 km below the surface. The bias introduced by the half space assumption is significant only at high frequency. We finally show how the attenuation estimates, calculated with different techniques, lead to different PGA decay with distance relationships, using the well known and well proven Boore’s method. This last result indicates that care must be used in selecting the correct estimate of the attenuation parameters for seismic risk purposes. We also discuss the reason why MLTWA may be chosen among all the other available techniques, due to its intrinsic stability, to obtain the right attenuation parameters

    Residuos sólidos y contaminación ambiental de la Laguna de Huacachina en los pobladores de Ica, 2023

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    En la investigación cuyo objetivo general fue determinar la relación entre los RS y la CA de la laguna de Huacachina en los pobladores de Ica, 2023. Se llevo a cabo un estudio de tipo básico, de nivel descriptivo correlacional, cuyo diseño de investigación fue no experimental, corte transversal y se tomó la decisión del enfoque cuantitativo. La muestra estuvo conformada por 84 personas como muestra. La técnica que se utilizó fue la encuesta y el instrumento dos cuestionarios aplicados a los pobladores. Se validaron los instrumentos con el juicio de expertos de teórico, metodólogo y estadístico, para la confiabilidad de cada instrumento se aplicó el alfa de Cronbach para ambas variables, por tratarse de una escala de Lickert, cuyos resultados fueron 0,982 para los RS y 00,982 para la CA. La investigación llego a la conclusión que los resultados del coeficiente de correlación Rho de Spearman existe una relación de tipo inversa rs = -,449* en la variable de residuos sólidos y la contaminación ambiental

    The role of microRNA in head and neck cancer: Current knowledge and perspectives

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    Head and neck cancer is one of the most commonly diagnosed malignancies worldwide. Patients with advanced disease stages frequently develop recurrences or distant metastasis, which results a five-year survival rates of less than 60% despite considerable advances in multimodality therapy. A better understanding of molecular basis of tumorigenesis is required to improve clinical outcomes and to develop new anti-cancer drugs. microRNAs (miRNAs) are a class of small, non-coding, RNA molecules that modulate gene expression post-Transcriptionally. They are important regulator in normal biological process; however miRNAs deregulation has been observed in many different tumors and is involved in tumorigenesis. miRNAs may act as tumor suppressors or as oncogenes. Several studies on head and neck cancer demonstrated how aberrant expression of miRNAs is involved in proliferation, metastasis, chemoresistence, and radioresistance. In addition, miRNAs are excellent biomarker targets because they circulate stable in human body fluids and can be obtained with non-invasive methods. Moreover, miRNAs up and down regulation has been correlated with specific cancer phenotype (poor prognosis, aggressiveness and resistance to treatment), playing a role as prognostic biomarkers. This review summarizes current finding on miRNAs in head and neck cancer and their potential role as target for next drug therapy. © 2014 by the authors

    A transiçao do ser adolescente puérpera ao papel materno sob o enfoque do cuidado de enfermagem

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    Orientadora: Ivete Palmira Sanson ZagonelDissertaçao (mestrado) - Universidade Federal do Paraná, Setor de Ciencias da Saúde, Programa de Pós-Graduaçao em Enfermagem. Defesa: Curitiba, 2004Inclui bibliografiaÁrea de concentraçao: Prática profissional em enfermagemResumo: Este estudo tem como objeto a transição ao papel materno vivenciada pelo ser adolescentepuérpera em seu existir. Surgiu das inquietações e da experiência como enfermeira edocente na área materno-infantil. Para a elucidação objetivou compreender o processo detransição ao papel materno vivenciado pelo ser adolescente puérpera sob o enfoque docuidado de enfermagem. As idéias de Meleis e autores pertinentes ao tema serviram desuporte teórico para a análise compreensiva dos depoimentos. O método utilizado foi apesquisa qualitativa com abordagem fenomenológica. A aproximação aos sujeitos foimediada pela entrevista semi-estruturada fenomenológica. O desvelamento compreensivopor meio da análise fenomenológica proposta por Martins e Bicudo (1994) possibilitou odesocultar da vivência do ser adolescente na simultaneidade da transição desenvolvimental,situacional e de saúde-doença para a aproximação ao fenômeno do alcance ao papelmaterno. Os sujeitos do estudo foram oito adolescentes puérperas atendidas no ambulatóriode uma maternidade pública de Curitiba. Foi possível apreender as unidades designificação: a transição desenvolvimental vivenciada pelo ser adolescente, a transiçãosituacional na experiência do ser diante da simultaneidade da adolescência e gestação, e atransição ao papel materno: mobilizando recursos internos e externos. A percepção do seradolescente puérpera a partir de sua visão de mundo mostra a compreensão de que oseventos transicionais adquirem diferentes significados para cada ser que experiencia amesma situação, necessitando do cuidado transicional de enfermagem para oenfrentamento e a adaptação que o papel materno exige. Como ser enfermeira me vienvolvida com as expressões do ser adolescente no processo de transição e foi possívelrefletir e lançar um olhar atento sobre minha própria cotidianidade, valorizar o ser em seumodo existencial a partir de sua singularidade. Percebi que a vivência de todo o processotransicional é permeada de possibilidades, o que significou abrir mão do preestabelecido, dopré-concebido para apreender o vivido, o fenômeno próprio do ser. Foi possível captar o seradolescente como um projetar-se, um vir-a-ser, com planos futuros de valorização pessoalocupando seu espaço de ser na vivência do papel materno. Logo, descobri que lidar com oser adolescente puérpera é relacionar-se com zelo, é cuidar atuando com dedicação,delicadeza, consideração, pondo-se disposta nesse cuidar baseada nas vivências passadase na expectativa de futuro. Assim a transição do ser adolescente acontece nasimultaneidade do ser adolescente, ser adolescente gestante e ser adolescente puérperanum movimento circular. A riqueza das informações deste estudo impulsionam a prosseguir,a continuar o desvelamento, a suscitar nos enfermeiros o desejo de buscar o inovador, odiferencial para executar o cuidado transicional voltado a cada situação em especial, diantede cada ser também especial. Este final de trabalho suscita o início de novas descobertas.Abstract: This study objectifies the transition to maternal role experienced by a puerperal teenager. Itevolved from my relentlessness and experience as a nurse and professor in the mother/childfield. It aimed to apprehend the transitional process to motherhood lived by a puerperalteenager in the light of nursing care. Meleis's ideas as well as other theme-related authorsgrounded the comprehensive analysis of the accounts. The method used was qualitativeresearch with a phenomenological approach. Encounter with the subjects was mediated by asemi-structured interview. Comprehensive elucidation by means of phenomenologicalanalysis proposed by Martins and Bicudo (1994) enabled to unveil a teenager's experiencealong the simultaneity of developmental, situational, health/disease transition to approach thephenomenon of reaching maternal role. The subjects involved in the study were eightpuerperal teenagers seen to in a day-clinic of a public maternity hospital in Curitiba/Brazil. Itwas possible to apprehend meaningful units: developmental transition experienced by theteenager, situational transition experienced by the teenager facing the simultaneity ofadolescence and gestation, and the transition to maternal role, demanding internal andexternal resources. The perception of a puerperal teenager through her world vision enablesto understand that transitional events take on different meanings to each subject who isundergoing the same situation, thus requiring transitional nursing care for coping andadaptation that the maternal role demands. It can be concluded that the researcher isinvolved by the expressions of a teenager going through this transitional process and is ledto ponder and cast a careful look over his/her own daily life, valuing the teenage being in herexistential way, due to her uniqueness. Experiencing the transitional process is permeatedby possibilities, which means to do away with settled, preconceived ideas to apprehend whatis being undergone, the phenomenon of the being. It was possible to understand theteenager as a future outlook, a coming to be, with future plans of self-valuing, struggling forher place while experiencing maternal role. Dealing with the puerperal teenager means acareful relationship, dedicated, delicate, thoughtful caring, willing to care based on pastexperience as well as on future expectations. Thus, those teenagers' transition occurs in around movement, simultaneous to adolescence, gestation and puerperium. The wealth ofinformation provided by this study encourages the continuation of unveiling, encouragesnurses to search for innovations, for the differential to carry out transitional care keeping inmind each unique situation, facing each unique being. Therefore, the conclusion of this studybrings forth the beginning of new breakthroughs in teaching, research and practice

    Fortaleciendo la expresión musical para desarrollar la creatividad en estudiantes del sexto grado de una Institución Educativa primaria de Ica, 2016

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    La presente investigación tuvo como objetivo determinar en qué medida el fortalecimiento de la expresión musical mejora la creatividad en estudiantes del sexto grado de la Institución Educativa Primaria Nº 22727 “Circulo de Periodista” de Ica. Considerando que es una investigación de tipo experimental se utilizó el diseño pre experimental. La población estuvo conformada por 33 estudiantes del sexto grado de educación primaria, así mismo la muestra quedo conformada por los 33 estudiantes de la Institución Educativa Primaria Nº 22727 “Circulo de Periodista” de Ica, los mismos que fueron elegidos mediante el muestreo no probabilístico por la técnica censal ya que es una población pequeña. Para la recolección de datos se elaboró cuestionario para determinar el nivel de creatividad el cual contiene 27 ítems, mientras que para el procesamiento de datos se utilizó la estadística descriptiva para la presentación de resultados en tablas y figuras; además de la estadística inferencial para la comprobación de las hipótesis. Los resultados determinaron que el desarrollo de talleres orientados al fortalecimiento de la expresión musical mejora de forma significativa en 61% el nivel de creatividad de los estudiantes del sexto grado de la Institución Educativa Primaria Nº 22727 “Circulo de Periodista” de Ica que pertenecen al grupo experimental

    Factores de riesgo asociados a la fibrilación auricular post operatoria en cirugía de revascularización miocárdica en el Hospital Nacional Edgardo Rebagliati Martins en el año 2010

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    El documento digital no refiere asesorPublicación a texto completo no autorizada por el autorDetermina la frecuencia de fibrilación auricular (FA) de nueva aparición en el postoperatorio de los pacientes sometidos a cirugía de revascularización miocárdica (CRM) e identificar los factores preoperatorios y perioperatorios. El estudio es transversal descriptivo, retrospectivo. Se utiliza la base de datos de pacientes que ingresan a Unidad de Cuidados Intensivos post cirugía para identificar a todos los pacientes sometidos a cirugía de revascularización miocárdica con o sin bypass cardiopulmonar realizada en el Hospital Nacional Edgardo Rebagliati Martins de enero a diciembre de 2010. Los resultados obtenidos son que de los 235 sujetos a quienes se les practicó una primera operación cardiaca, 84,3 % eran varones y tenían una edad promedio 67 ± 9 años. Se produjo una FA de nueva aparición en 61 sujetos (26%). Los factores asociados a aparición de FA fueron insuficiencia renal, insuficiencia cardiaca congestiva, presencia de insuficiencia mitral, nivel de Euroscore logarítmico, tiempo quirúrgico prolongado. En los pacientes con FA postoperatoria hubo una frecuencia significativamente mayor de IMA postoperatorio, neumonía, neumotórax, falla renal aguda, anemia aguda severa; así como una mayor estancia en UCI, hospitalización, tasa de reingreso y de muerte. Se concluye que la aparición de FA es frecuente tras la cirugía cardiaca y se asocia a un aumento de la morbimortalidad.Trabajo académic
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