Comparison of short-term clinical and pathological outcomes after transanal versus laparoscopic total mesorectal excision for low anterior rectal resection due to rectal cancer : a systematic review with meta-analysis

Background: Transanal total mesorectal excision (TaTME) is a new technique that is designed to overcome the limits of the open and laparoscopic approach for rectal resections. Objective: This study is designed to compare TaTME with standard laparoscopic TME (LaTME). Methods: We searched Medline, Embase, and Scopus databases covering a up to October 2018. Inclusion criteria for study enrolment: (1) study comparing laparoscopic resection of rectal cancer vs. TaTME for rectal malignancy, (2) reporting of overall morbidity, operative time, or major complications. Results: Eleven non-randomized studies were eligible with a total of 778 patients. We found statistical significant differences in regard to major complications in favour of TaTME (RR = 0.55; 95% CI 0.31⁻0.97; p = 0.04). We did not found significant differences regarding overall complications intraoperative adverse effects, operative time, anastomotic leakage, intra-abdominal abscess occurrence, Surgical Site Infection, reoperations, Length of stay, completeness of mesorectal excision, R0 resection rate, number of harvested lymph nodes, circumferential resection margin, and distal resection margin. Conclusions: This meta-analysis shows benefits of TaTME technique regarding major postoperative complications. Regarding clinicopathological features transanal approach is not superior to LaTME. Currently, the quality of the evidence on benefits of TaTME is low due to lack of randomized controlled trials, which needs to be taken into consideration in further evaluation of the technique. Further evaluation of TaTME require conducting large randomized control trials

Blood serum calorimetry indicates the chemotherapeutic efficacy in lung cancer treatment

Chemotherapy is a primary treatment for the metastatic lung cancer patients. To select the most effective combination of drugs, we need an efficient way of assessing tumor response. Here, we showed that differential scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the treatment. If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung cancer (NSCLC) case is similar to the those of the healthy individuals. If treatment fails, notable changes occur in the DSC profile of NSCLC patient's blood serum. Our preliminary work illustrates how thermal analysis of changes in the heat capacity of blood serum proteins can provide an insight into patient response to chemotherapy - the essential information for any successive lung cancer treatment

Relaxation Time of Proton Adsorption from Solution onto Magnetite and Anatase: Classical and New Theoretical Approach

The pH dependence of relaxation time of proton adsorption was analyzed by the classical Theory of Activated Adsorption and Desorption (TAAD) and the recently developed Statistical Rate Theory of Interfacial Transport (SRT). It was found that both models predicted different behaviour of relaxation time as a function of pH. Since SRT and TAAD give an identical result for relaxation time of adsorption of uncharged species, it is suggested that the surface potential is a key factor in ion adsorption kinetics. Additionally, only the order of magnitude of the ion adsorption rate constant can be estimated from the analysis of experimental data because the surface potential and the total concentration of adsorption sites are not known exactly

Theory, Experiment and Computer Simulation of the Electrostatic Potential at Crystal/Electrolyte Interfaces

In this feature article we discuss recent advances and challenges in measuring, analyzing and interpreting the electrostatic potential development at crystal/electrolyte interfaces. We highlight progress toward fundamental understanding of historically difficult aspects, including point of zero potential estimation for single faces of single crystals, the non-equilibrium pH titration hysteresis loop, and the origin of nonlinearities in the titration response. It has been already reported that the electrostatic potential is strongly affected by many second order type phenomena such as: surface heterogeneity, (sub)surface transformations, charge transfer reactions, and additional potential jumps at crystal face edges and/or Schottky barriers. Single-crystal electrode potentials seem particularly sensitive to these phenomena, which makes interpretation of experimental observations complicated. We hope that recent theory developments in our research group including an analytical model of titration hysteresis, a perturbative surface potential expansion, and a new surface complexation model that incorporates charge transfer processes will help experimental data analysis, and provide unique insights into the electrostatic response of nonpolarizable single-crystal electrodes

Relaxation Time of Proton Adsorption from Solution onto Magnetite and Anatase: Classical and New Theoretical Approach*

The pH dependence of relaxation time of proton adsorption was analyzed by the classical Theory of Activated Adsorption and Desorption (TAAD) and the recently developed Statistical Rate Theory of Interfacial Transport (SRT). It was found that both models predicted different behaviour of relaxation time as a function of pH. Since SRT and TAAD give an identical result for relaxation time of adsorption of uncharged species, it is suggested that the surface potential is a key factor in ion adsorption kinetics. Additionally, only the order of magnitude of the ion adsorption rate constant can be estimated from the analysis of experimental data because the surface potential and the total concentration of adsorption sites are not known exactly. Keywords: magnetite anatase proton adsorption kinetics relaxation time statistical rate theory CROATICA CHEMICA ACTA CCACAA 80 (3-4) 345¿349 (2007