A realist interpretation of quantum mechanics based on undecidability due to gravity

We summarize several recent developments suggesting that solving the problem of time in quantum gravity leads to a solution of the measurement problem in quantum mechanics. This approach has been informally called "the Montevideo interpretation". In particular we discuss why definitions in this approach are not "for all practical purposes" (fapp) and how the problem of outcomes is resolved.Comment: 7 pages, IOPAMS style, no figures, contributed to the proceedings of DICE 2010, Castiglioncello, slightly improved versio

Quantum Systems Equilibrate Rapidly for Most Observables

Considering any Hamiltonian, any initial state, and measurements with a small number of possible outcomes compared to the dimension, we show that most measurements are already equilibrated. To investigate non-trivial equilibration we therefore consider a restricted set of measurements. When the initial state is spread over many energy levels, and we consider the set of observables for which this state is an eigenstate, most observables are initially out of equilibrium yet equilibrate rapidly. Moreover, all two-outcome measurements, where one of the projectors is of low rank, equilibrate rapidly.Comment: Main Text: 5 pages, 1 figure. Appendices: 7 pages, 1 figur

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Acknowledgements: Authors want to express their gratitude to Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder (NorthWestern, Chicago, IL, USA) for the generous gift of mAbs (TG-3, Alz-50, and MC1), and (TauC-3), respectively, and to M. en C. Ivan J. Galván-Mendoza for his support in confocal microscopy, and Ms. Maricarmen De Lorenz for her secretarial assistance. We also want to express our gratitude to the Mexican Families who donate the brain of their loved ones affected with Alzheimer's disease, and made possible our research. This work was financially supported by CONACyT grant, No. 142293 (For R.M).Peer reviewedPublisher PD

Accuracy of periodontitis diagnosis obtained using multiple molecular biomarkers in oral fluids: A systematic review and meta‐analysis

Aim To determine the accuracy of biomarker combinations in gingival crevicular fluid (GCF) and saliva through meta-analysis to diagnose periodontitis in systemically healthy subjects. Methods Studies on combining two or more biomarkers providing a binary classification table, sensitivity/specificity values or group sizes in subjects diagnosed with periodontitis were included. The search was performed in August 2022 through PUBMED, EMBASE, Cochrane, LILACS, SCOPUS and Web of Science. The methodological quality of the articles selected was evaluated using the QUADAS-2 checklist. Hierarchical summary receiver operating characteristic modelling was employed to perform the meta-analyses (CRD42020175021). Results Twenty-one combinations in GCF and 47 in saliva were evaluated. Meta-analyses were possible for six salivary combinations (median sensitivity/specificity values): IL-6 with MMP-8 (86.2%/80.5%); IL-1β with IL-6 (83.0%/83.7%); IL-1β with MMP-8 (82.7%/80.8%); MIP-1α with MMP-8 (71.0%/75.6%); IL-1β, IL-6 and MMP-8 (81.8%/84.3%); and IL-1β, IL-6, MIP-1α and MMP-8 (76.6%/79.7%). Conclusions Two-biomarker combinations in oral fluids show high diagnostic accuracy for periodontitis, which is not substantially improved by incorporating more biomarkers. In saliva, the dual combinations of IL-1β, IL-6 and MMP-8 have an excellent ability to detect periodontitis and a good capacity to detect non-periodontitis. Because of the limited number of biomarker combinations evaluated, further research is required to corroborate these observationsThis study was funded by the Instituto de Salud Carlos III (ISCIII) through the project PI21/00588 and co-funded by the European UnionS

A 15-year perspective of the fabry outcome survey

The Fabry Outcome Survey (FOS) is an international long-term observational registry sponsored by Shire for patients diagnosed with Fabry disease who are receiving or are candidates for therapy with agalsidase alfa (agala). Established in 2001, FOS provides long-term data on agala safety/efficacy and collects data on the natural history of Fabry disease, with the aim of improving clinical management. The FOS publications have helped establish prognostic and severity scores, defined the incidence of specific disease variants and implications for clinical management, described clinical manifestations in special populations, confirmed the high prevalence of cardiac morbidity, and demonstrated correlations between ocular changes and Fabry disease severity. These FOS data represent a rich resource with utility not only for description of natural history/therapeutic effects but also for exploratory hypothesis testing and generation of tools for diagnosis/management, with the potential to improve future patient outcomes

Efecto de la liofilización en la retención de antocianinas de los frutos de calafate (Berberis microphylla G. Forst.) y su incorporación en cerveza

Los frutos de calafate son extremadamente ricos en compuestos antioxidantes, principalmente antocianinas. El objetivo fue evaluar la influencia de la liofilización sobre el contenido de antocianinas en los calafates durante el almacenamiento. Un grupo de frutos fue analizado inmediatamente y los restantes fueron sometidos a congelado a -80 ºC y liofilización. Por otra parte, a cerveza comercial tipo block se le adicionó 1,0; 2,5; 5,0 o 20 g L-1 de frutos liofilizados y pulverizados. Los frutos frescos tuvieron 35 mg g-1 de antocianinas y la liofilización redujo su contenido en 7 %. El contenido de antocianinas se mantuvo sin variaciones por 21 y 45 días respectivamente. Hacia los 60 días el contenido de antocianinas de los frutos liofilizados representó el 67% del contenido inicial. El pH de la cerveza fue de 4,34 y no varió con el agregado de polvo de calafate hasta 5 g L-1. En el caso de las cervezas con el agregado de 20 g L-1 el pH descendió a 4,00. El agregado de calafate provocó un cambio en el color de la cerveza debido a su aporte de antocianinas, y este cambio en el color fue función de la cantidad de fruto adicionado. La absorbancia a 520 nm fue de 0,230; 0,254; 0,291; 0,353 y 0,644 para la cerveza sin agregado o con 1,0; 2,5; 5,0 o 20 g L-1 de calafate  espectivamente. Solo cantidades mayores a 2,5 g L-1 de polvo adicionado provocaron un incremento de actividad antioxidante, llegando al 30 % con la adición de 20 g L-1. La liofilización es una estrategia adecuada para preservar las antocianinas de los frutos de calafate sin alteraciones por 45 días. Dependiendo de la cantidad adicionada, el calafate provoca en la cerveza cambio de color y descenso del pH que puede ser de utilidad en cervezas especiales

Donovanosis en mujeres indígenas

La donovanosis es una rara infección causada por la bacteriaCalymmatobacteriumgranulomatisque produce importantes lesiones ulcero-granulomatosas, preferentemente en la zonaanogenital.Considerada como enfermedad de trasmisión sexual, no es ésta la única vía detrasmisión, siendo también importantes las condiciones higiénicas, socioeconómicas y ambientalesen su etiopatogenia.Afecta áreas tropicales de varios continentes, incluido el americano, donde hayseries descriptas en varios países. En el Paraguay ha sido poco reportada, por lo que esta serie decuatro pacientes mujeres, jóvenes, indígenas de varias parcialidades, con lesiones exuberantes enzona anogenital, de larga evolución, tres de ellas embarazadas y dos con extensión a órganosinternos, es importante. El objetivo de este trabajo es llamar la atención sobre un problema de granmorbilidad y que exige mejorar la cobertura de salud y condiciones de vida de estas comunidadesindígenas

Acordo entre equações de predição e o método 1RM em quatro exercícios de treinamento de resistência

El objetivo de este trabajo fue conocer el nivel de concordancia entre ecuaciones de estimación con el método de 1 RM en una muestra de 30 jóvenes experimentados. Se ejecutaron cuatro ejercicios: sentadilla con barra libre (SEN), press en banco horizontal (PB), peso muerto (PMu) y press militar (PMi) teniendo un mínimo y un máximo de 1 a 7 repeticiones respectivamente. Se consideraron 6 ecuaciones de predicción: Brzycki (1993), Epley (1995), Lander (1985), Cummings y Finn (1998), O´Conner et al. (1989), y Abadie et al. (1999). Se calculó la media y desviación estándar, así como el nivel de correlación intraclase para estudiar el nivel de la asociación y el método Bland-Altman. Los valores medios de 1RM obtuvieron muy buena correlación en las ecuaciones de Brzycki (1993) y O´Conner et al. (1989) en el ejercicio de SEN, Epley (1995), Brzycki (1993), O´Conner et al. (1989) y Cumming y Finn (1998) en el ejercicio de PB, y Cummings y Finn (1998) en el ejercicio de PMu. La ecuación predictiva de Cummings y Finn (1998) y Epley (1995) también puede ser usada para calcular 1RM en el PMi. Para mejorar la dosificación de cargas, se recomienda utilizar las ecuaciones de predicción de acuerdo con el ejercicio que se quiera llevar a cabo.The aim of this study was to determine the level of agreement between estimation equations with the 1RM method in a sample of 30 experienced young people. Four exercises were performed: barbell squat (SQ), horizontal bench press (BP), dead weight (DW), and military press (MiP), with a minimum and a maximum of 1 to 7 repetitions respectively. Six prediction equations were considered: Brzycki (1993), Epley (1995), Lander (1985), Cummings and Finn (1998), O'Conner et al. (1989), and Abadie et al. (1999). The mean and standard deviation were calculated, as well as the level of intraclass correlation and the Bland-Altman method to study the association. The mean values of 1RM obtained very good correlation in the equations of Brzycki (1993) and O'Conner et al. (1989) in the SQ, Epley (1995) in the BP exercise, and Cummings and Finn (1998) in the DW exercise. The predictive equation of Cummings and Finn (1998) and Epley (1995) can also be used to calculate 1RM in MiP. To improve the dosage of loads, it is recommended to use the predictive equations according to the exercise to be performed.O objetivo deste trabalho foi conhecer o nível de concordância entre as equações de estimação e o método de 1RM numa amostra de 30 jovens experientes. Foram executados quatro exercícios: agachamento com barra livre (SEN, por suas siglas em espanhol), press em banco horizontal (PB), peso morto (PMu) e press militar (PMi) com um mínimo e um máximo de 1 a 7 repetições, respectivamente. Foram consideradas 6 equações de predição: Brzycki (1993), Epley (1995), Lander (1985), Cummings e Finn (1998), O'Conner et al. (1989), e Abadie et al. (1999). Foram calculadas a média e o desvio estândar, e também o nível de correlação intraclasse e o método de Bland-Altman para analisar a associação. Os valores médios de 1RM conseguiram uma boa correlação nas equações de Brzycki (1993) e O'Conner et al. (1989) no exercício de SEN, Epley (1995) no exercício de PB, e Cummings e Finn (1998) no exercício de PMu. A equação preditiva de Cummings e Finn (1998) e Epley (1995) também é possível ser utilizada para calcular 1RM no PMi. Para melhorar a dosificação de cargas, é recomendável utilizar as equações de predição de acordo com o exercício que se deseje executar.Facultad de Humanidades y Ciencias de la Educació