1,155 research outputs found
Validation of the Lower Tagus Valley velocity and structural model using ambient noise broadband measurements
Along his history the Lower Tagus Valley (LTV) region was shaken by several earthquakes, some of them were
produced in large ruptures of offshore structures located southwest of the Portuguese coastline, among these we
the Lisbon earthquake of 1 November 1755; other moderates earthquakes were produced by local sources such as
the 1344, 1531 and the 1909 Benavente earthquake.
In order to promote an improved assessment of the seismic hazard in this region, we propose the introduction
of realistic methods on the prediction of ground motion produced by moderate to large earthquakes in LTV.
This process involves the establishment of a structural 3D model based on all the available geophysical and
geotechnical data on the area (seismic, gravimetric, deep wells and geological outcrops) and the determination of
wave propagation from a finite difference method: by applying the E3D program [1,2].
To confirm this model we use broadband ambient noise measurements collected in two profiles with azimuth
perpendicular to the basin axis and we applied the horizontal to vertical (H/V) spectral ratio method [3] to the
recordings in order to estimate the amplification of the basin. The H/V curves obtained reveals the existence of two
low frequency peaks centered on 0.2 a 1 Hz frequencies[4]. These peaks are strongly related with the thickness
of Cenozoic and alluvial sediments. By inversion of the H/V curve, we obtain a more detailed velocity model for
the region where the profile were determined, which is in good agreement with borehole data and other results
obtained with magnetic and seismic reflection methods
Preparation and characterization of a powder manufactured by spray drying milk based formulations for the delivery of theophylline for pediatric use
The study considered different fat content cow milks to deliver theophylline orally. Powders were obtained by spray drying theophylline dispersed in fresh milk according to a full factorial design of experiments. The correlation of the independent (milk fat content, skimmed to whole milk, theophylline fraction, and drying temperature) with the dependent (yield of the process and residual moisture content of the powder, particle size and distribution, density, surface polarity and theophylline content) variables enabled the construction of a mathematical model and a desirability function to predict the optimized levels of the variables. Good predictability was achieved for density, fairly good for yield, moisture content, surface polarity and yield whereas theophylline content and particle size were poorly predicted. Powders with up to 60% theophylline presented spherical (3.7 \ub5m) and narrow sized distribution particles, with high density (1.6 g/cm 123) in high yields (>70%), stable for 6 month (25 \ub0C/65%RH) in a closed container and for no longer than 2 day, after reconstitution in water due to bacteria growth (no pathogens) without signs of crystallinity. Preparations obtained with low fat milk were less stable than high fat content milk. Therefore, fresh milk can be transformed into stable powder compositions to prepare oral solid/liquid dosage forms to deliver individualized doses of theophylline
Effects of reduced glutathione and catalase on the kinematics and membrane functionality of sperm during liquid storage of ram semen
AbstractThe objective of this study was to evaluate the effects of reduced glutathione (GSH) and catalase (CAT) supplementation on the kinematics and membrane functionality of sperm during the liquid storage of ram semen, cooled at 5°C, for up to 24h. Semen samples from four rams were pooled, diluted with Tris-egg yolk extender without antioxidants (control) or supplemented with either CAT (100, 200, and 400U/mL) or GSH (100, 200, and 400mM) at a final concentration of 50Ă106sperm/mL. Sperm kinematics, which was analyzed by computer-assisted sperm analysis (CASA), and membrane functionality, which was analyzed using the hypo-osmotic swelling test (HOST), were determined after the addition of the semen samples at different processing times (fresh/diluted, 1.5, 6, 12, and 24h, at 5°C). No significant differences were recorded in the kinematics or membrane functionality between treatments at different times. The supplementation of diluents with 100 and 200U/mL of CAT prevented the harmful effects of cooling on total sperm motility. No significant differences were observed in progressive sperm motility throughout processing, regardless of the treatment and time of evaluation. Supplementation with 400mM GSH resulted in an earlier reduction (P<0.05) of total sperm motility, a decrease in rapid sperm rate and a reduction in curvilinear velocity during incubation, at 5°C. The cooling induced a reduction (P<0.05) in the percentage of sperm with a functional plasma membrane (HOST), especially after 1.5h of incubation. Based on the results of the present study, the addition of CAT (100 and 200U/mL) reduced the deleterious effects of cooling on total motility in ram sperm maintained at 5°C for 24h, although it did not affect the functionality of the sperm membranes. However, the addition of 400mM GSH caused negative effects on the velocity parameters of the sperm
A lepra do pessegueiro. Ensaios de tratamento nas ĂŠpocas de 1958-59 e 1959-60
info:eu-repo/semantics/publishedVersio
Uma grave micose do bersim: Aureobasidium caulivorum (Kirchner) B. Cooke
info:eu-repo/semantics/publishedVersio
Os insecticidas malathion, parathion e meta-iso-sistox na luta contra o Hyalopterus amygdali Blanch.
info:eu-repo/semantics/publishedVersio
Valuation of fresh produce at Local Markets, consumer´sperspectives
[resumo][abstract
PCN36 Cost Analysis Model Between The Cobas Braf Test And Sanger Sequencing When Treating Malignant Melanoma Based On The Presence Of V600 Mutations
L'informe de gestiĂł de l'exercici 201
The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity
NOTICE: this is the authorâs version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2009 Feb;71(2):377-386. Epub 2008 Oct 17.The work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by bcyclodextrin
(bCD), and the effect of water in such a process, and makes a comparison of their complexation
yields. Two methods were considered: kneading of a binary mixture of the drug, bCD, and inclusion
of either IB or IN in aqueous solutions of bCD. In the latter method water was removed by air stream,
spray-drying and freeze-drying. To prove the formation of complexes in final products, optical microscopy,
UV spectroscopy, IR spectroscopy, DSC, X-ray and NMR were considered. Each powder was added
to an acidic solution (pH = 2) to quantify the concentration of the drug inside bCD cavity. Other media
(pH = 5 and 7) were used to prove the existence of drug not complexed in each powder, as the drugs solubility
increases with the pH. It was observed that complexation occurred in all powders, and that the
fraction of drug inside the bCD did not depend neither on the method of complexation nor on the
processes of drying considered
The Differentiation and Promotion of Studentsâ Rights in Portugal
This investigation includes a differential study (Study 1)
and a quasi-experimental research (Study 2). In Study 1, the objective
was to establish to what extent studentsâ rights existed and analyse
the differentiation between studentsâ rights with Portuguese and
immigrant mothers, throughout school years. The sample consisted of
537 students with Portuguese and immigrant mothers, distributed by
different school years (7th, 9th and 11th grades). The Childrenâs Rights
Scale (Hart et al., 1996; Veiga, 2001) was used. In Study 2, the purpose
was to analyse the effects on studentsâ rights of the use by teachers of a
communicational intervention program, supervised by school psychologists.
The sample involved 7th and 9th grade students, in a total of
four classes, two forming the experimental groups (n = 36) and two the
control groups (n = 43); as in Study 1, the Childrenâs Rights Scale was used. The results indicated the effectiveness of the communicational intervention program on studentsâ rights and are consistent with previous studies. An implication is that psychologists and teachers, working together and taking a human rights perspective, may develop an important role in projects to promote the studentsâ rights
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