Formazione ed evoluzione di un concetto. Il sublime in Schelling

[Resumen] El presente trabajo reconsidera el significado y la función del concepto de sublime en la filosofía del arte de Schelling, que, como ocurre en general en los teóricos de la estética idealista y romántica, pone al menos prima facie en segundo plano la cuestión de lo sublime para concentrarse exclusivamente en la idea de lo bello. La reflexión schellinguiana sobre lo sublime parte de la revisión operada por Schiller del sublime kantiano, que de ser una noción originariamente ligada a la experiencia estética de la naturaleza deviene la categoría central de la teoría de la tragedia. En la metafísica del arte de Schelling la idea de belleza, definida previamente según el esquema clasicista como quietud y conciliación de los opuestos, experimenta a través de la integración en ella del concepto de sublime una trasformación radical, asumiendo rasgos característicos del último: la relación dinámica y la contradicción entre los opuestos, de los cuales la tragedia constituye la figura ejemplar. Puesto que, para Schelling, la tragedia es la forma suprema de arte, la idea misma de lo bello como expresión sensible de la verdad se redefine a través de la estrecha proximidad a lo sublime.[Sommaire] Cette contribution se propose de réexaminer le rôle et la fonction du concept du sublime dans la philosophie de l’art de Schelling, chez lequel, comme chez les autres théoriciens romantiques et idéalistes de l’esthétique, il est surtout question, apparemment, de l’idée du beau, tandis que le sublime semble occuper une position subordonnée. La théorie de Schelling se rattache à la réélaboration schillérienne du sublime naturel de Kant, qui devient dans la perspective de Schiller la catégorie centrale de la théorie de la tragédie. Or, dans la métaphysique de l’art de Schelling l’idée de la beauté, qui se définit selon le schéma classiciste comme conciliation des opposés, subit en intégrant le concept du sublime une transformation radicale. La beauté prend sur soi les traits caractéristiques de la sublimité, à savoir la relation dynamique et la contradiction entre les opposés, dont la tragédie est figure exemplaire. Comme la tragédie est, selon Schelling, la forme d’art la plus haute, l’idée même du beau en tant qu’expression sensible de la vérité se redéfinit à travers sa proximité étroite avec le sublime.[Abstract] This paper reconsiders the role played by the notion ‘sublime’ in Schelling’s philosophy of art, a notion whose relevance, with regard to Schelling as well as to all philosophers of Romanticism, is at first glance not apparent. Schelling’s reflexion on sublimity elaborates on the revision of the Kantian conception by Schiller, who transformed the notion, originally pertaining to the domain of the aesthetic experience of nature, into the basic structure of the theory of tragedy. Within Schelling’s metaphysics of art, the idea of artistic beauty, previously defined in terms of harmony and appeasement, is radically reshaped, taking on the distinctive features of sublimity, viz. dynamics and conflict. Since tragedy, for Schelling, is the highest form of work of art, his idea of beauty as expression of truth eventually merges with the notion “sublimity”

Literature and action. On Hegel’s interpretation of chivalry

Literature plays a relevant role in Hegel’s philosophical discourse. On the one hand, literary references are often interwoven with his speculative argumentation, on the other hand, the Aesthetics regards poetry as the highest form of artistic expression, for it is able to represent the different ways of human action and to bring up their hidden ideal presuppositions. The aim of this paper is to show how the concept of action is crucial to the interpretation of literary phenomena in the Aesthetics, but assumes different configurations in relation to the historical transformation of the concept of subjectivity. To verify the specifically aesthetic import of concepts such as action and recognition, which originally belong to the ethical-political sphere, I will examine Hegel’s interpretation of the chivalric literature, which is present in various areas and with different functions in the structure of the Aesthetics, as a component of his theory of subjectivity. This topic has been little studied but offers an interesting perspective on some problematic points of Hegel’s theory: the controversial relation between the structural dimension of the concept of art and historical development of artistic forms, the apparently univocal paradigm of classic beauty, and the definition of artistic modernity

Who’s afraid of Seneca? Conflict and pathos in the romantic-idealistic theory of tragedy

This paper reconsiders the Idealistic aesthetics of tragedy from an unconventional point of view. It investigates the relationship between theory and dramatic canon by focusing on those works and authors that are excluded from the canon by the theoretical discourse. My aim is to show that Idealist philosophers and Romantic critics concur in constructing a unitary model of the tragic conflict that is partly defined through its contraposition to the ‘Senecan’ conception of tragedy as a representation of suffering and as a dialectic of passions. Seneca here stands for an entire line of European dramaturgy, which involves Shakespeare and culminates in French Classicism. This contrast does not merely concern a literary model, but also, more generally, the conception of subjectivity underlying the dramaturgy of passions. This paper thus helps to shed light on the controversial relationship between the idealistic philosophy of the tragic with modern tragedy at large. Keywords: Theory of Tragedy, Idealism, Seneca, Hegel, Patho

Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster I. REGULATION OF PRODYNORPHIN GENE EXPRESSION BY NUCLEAR PROTEIN KINASE C

Prodynorphin gene expression was investigated in adult ventricular myocytes isolated from normal (F1B) or cardiomyopathic (BIO 14.6) hamsters. Prodynorphin mRNA levels were higher in cardiomyopathic than in control myocytes and were stimulated by treatment of control cells with the protein kinase C (PKC) activator 1, 2-dioctanoyl-sn-glycerol. Both chelerythrine and calphostin C, two PKC inhibitors, abolished the stimulatory effect of the diglyceride and significantly reduced prodynorphin gene expression in cardiomyopathic myocytes. Nuclear run-off experiments indicated that the prodynorphin gene was regulated at the transcriptional level and that treatment of nuclei isolated from control cells with 1, 2-dioctanoyl-sn-glycerol increased prodynorphin gene transcription, whereas chelerythrine or calphostin C abolished this transcriptional effect. Direct exposure of nuclei isolated from cardiomyopathic myocytes to these inhibitors markedly down-regulated the rate of gene transcription. The expression of PKC-alpha, -delta, and -epsilon, as well as PKC activity, were increased in nuclei of cardiomyopathic myocytes compared with nuclei from control cells. The levels of both intracellular and secreted dynorphin B, a biologically active product of the gene, were higher in cardiomyopathic than in control cells and were stimulated or inhibited by cell treatment with 1,2-dioctanoyl-sn-glycerol or PKC inhibitors, respectively

Diving response after a one-week diet and overnight fasting

Background: We hypothesized that overnight fasting after a short dietary period, especially with carbohydrates, could allow performing breath-hold diving with no restraint for diaphragm excursion and blood shift and without any increase of metabolism, and in turn improve the diving response. Methods: During two separate sessions, 8 divers carried out two trials: (A) a 30-m depth dive, three hours after a normal breakfast and (B) a dive to the same depth, but after following a diet and fasting overnight. Each test consisted of 3 apnea phases: descent, static and ascent whose durations were measured by a standard chronometer. An impedance cardiograph, housed in an underwater torch, provided data on trans-thoracic fluid index (TFI), stroke volume (SV), heart rate (HR) and cardiac output (CO). Mean blood pressure (MBP), arterial O-2 saturation (SaO(2)), blood glucose (Glu) and blood lactate (BLa) were also collected. Results: In condition B, duration of the static phase of the dive was longer than A (37.8 +/- 7.4 vs. 27.3 +/- 8.4 s respectively, P < 0.05). In static phases, mean Delta SV value (difference between basal and nadir values) during fasting was lower than breakfast one (-2.6 +/- 5.1 vs. 5.7 +/- 7.6 ml, P < 0.05). As a consequence, since mean. HR values were equally decreased in both metabolic conditions, mean. CO value during static after fasting was lower than the same phase after breakfast (-0.4 +/- 0.5 vs. 0.4 +/- 0.5 L . min(-1) respectively, P < 0.05). At emersion, despite the greater duration of dives during fasting, SaO(2) was higher than A (92.0 +/- 2.7 vs. 89.4 +/- 2.9 % respectively, P < 0.05) and BLa was lower in the same comparison (4.2 +/- 0.7 vs. 5.3 +/- 1.1 mmol L-1, P < 0.05). Conclusions: An adequate balance between metabolic and splancnic status may improve the diving response during a dive at a depth of 30 m, in safe conditions for the athlete's healt

Mean blood pressure assessment during post-exercise: Result from two different methods of calculation

At rest the proportion between systolic and diastolic periods of the cardiac cycle is about 1/3 and 2/3 respectively. Therefore, mean blood pressure (MBP) is usually calculated with a standard formula (SF) as follows: MBP = diastolic blood pressure (DBP) + 1/3 [systolic blood pressure (SBP) – DBP]. However, during exercise this proportion is lost because of tachycardia, which shortens diastole more than systole. We analysed the difference in MBP calculation between the SF and a corrected formula (CF) which takes into account changes in the diastolic and systolic periods caused by exercise-induced tachycardia. Our hypothesis was that the SF potentially induce a systematic error in MBP assessment during recovery after exercise. Ten healthy males underwent two exercise-recovery tests on a cycle-ergometer at mild-moderate and moderate-heavy workloads. Hemodynamics and MBP were monitored for 30 minutes after exercise bouts. The main result was that the SF on average underestimated MBP by –4.1 mmHg with respect to the CF. Moreover, in the period immediately after exercise, when sustained tachycardia occurred, the difference between SF and CF was large (in the order of -20-30 mmHg). Likewise, a systematic error in systemic vascular resistance assessment was present. It was concluded that the SF introduces a substantial error in MBP estimation in the period immediately following effort. This equation should not be used in this situation

Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study

Background: Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors related to AB. Subsequently, to assess whether affective temperament dimensions may contribute to the presence and severity of AB. Methods: Patients with BD were recruited. AB was evaluated through the modified overt aggression scale (MOAS); affective temperaments were assessed with the TEMPS-A. A cluster analysis was conducted based on TEMPS-A and MOAS scores. Stepwise backward logistic regression models were used to identify the predictive factors of cluster membership. Results: 799 patients with BD were enrolled. Three clusters were determined: non-aggressive (55.5 %), self-aggressive (18 %), and hetero-aggressive (26.5 %). Depressive, irritable, and anxious temperament scores significantly increased from the non-aggressive (lower) to the self-aggressive (intermediate) and the hetero-aggressive group (highest). A positive history of a suicide attempt (B = 5.131; OR = 169.2, 95 % CI 75.9; 377) and rapid cycling (B = -0.97; OR = 0.40, 95 % CI 0.17; 0.95) predicted self-aggressive cluster membership. Atypical antipsychotics (B = 1.19; OR = 3.28, 95 % CI 2.13; 5.06) or SNRI treatment (B = 1.09; OR = 3, 95 % CI 1.57; 5.71), psychotic symptoms (B = 0.73; OR = 2.09, 95 % CI 1.34; 3.26), and history of a suicide attempt (B = -1.56; OR = 0.20, 95 % CI 0.11; 0.38) predicted hetero-aggressive cluster membership. Limitations: Recall bias might have affected the recollection of AB. Conclusions: Clinical factors orientate the prevention of different ABs in BD. Affective temperaments might play a role in preventing AB since patients with more pronounced affective temperaments might have an increased risk of showing AB, in particular hetero-AB