Fractal Conductance Fluctuations of Classical Origin

In mesoscopic systems conductance fluctuations are a sensitive probe of electron dynamics and chaotic phenomena. We show that the conductance of a purely classical chaotic system with either fully chaotic or mixed phase space generically exhibits fractal conductance fluctuations unrelated to quantum interference. This might explain the unexpected dependence of the fractal dimension of the conductance curves on the (quantum) phase breaking length observed in experiments on semiconductor quantum dots.Comment: 5 pages, 4 figures, to appear in PR

Design and Modelling of the Powertrain of a Hybrid Fuel Cell Electric Vehicle

This paper presents a Fuel Cell Electric Vehicle (FCEV) powertrain development and optimization, aiming to minimize hydrogen consumption. The vehicle is a prototype that run at the Shell Eco-marathon race and its powertrain is composed by a PEM fuel cell, supercapacitors and a DC electric motor. The supercapacitors serve as an energy buffer to satisfy the load peaks requested by the electric motor, allowing a smoother (and closer to a stationary application) working condition for the fuel cell. Thus, the fuel cell can achieve higher efficiency rates and the fuel consumption is minimized. Several models of the powertrain were developed using MATLAB-Simulink and then experimentally validated in laboratory and on the track. The proposed models allow to evaluate two main arrangements between fuel cell and supercapacitors: 1) through a DC/DC converter that sets the FC current to a desired value; 2) using a direct parallel connection between fuel cell and supercapacitors. The results obtained with the direct parallel connection (with the appropriate sizing of the overall capacity) have highlighted a significant efficiency advantage, while the DC/DC converter insertion enables an improved control of the fuel cell current and requires a smaller capacitance. Furthermore, a sizing methodology for the supercapacitors capacitance is proposed for both layouts: with the DC/DC converter it mainly depends on the energy range provided by supercapacitors to the electric motor, while in the direct parallel connection the supercapacitors sizing is outlined by concurrently evaluating the circuit's predicted hydrogen consumption and granting the most suitable conditions to increase the fuel cell performance. Finally, the results obtained from the model were validated by comparing them with experimental data obtained in the laboratory and on the track

Information-theoretic determination of ponderomotive forces

From the equilibrium condition $\delta S=0$ applied to an isolated thermodynamic system of electrically charged particles and the fundamental equation of thermodynamics ($dU = T dS-(\mathbf{f}\cdot d\mathbf{r})$) subject to a new procedure, it is obtained the Lorentz's force together with non-inertial terms of mechanical nature. Other well known ponderomotive forces, like the Stern-Gerlach's force and a force term related to the Einstein-de Haas's effect are also obtained. In addition, a new force term appears, possibly related to a change in weight when a system of charged particles is accelerated.Comment: 10 page

The Role of Accessory Obturator Arteries in Prostatic Arterial Embolization

In 9 of 491 patients (1.8%) who underwent prostatic arterial embolization (PAE) for benign prostatic hyperplasia from March 2009-November 2013, prostatic arteries arose from the external iliac artery via an accessory obturator artery (AOA). Computed tomography angiography performed before the procedure identified the variant and allowed planning before the procedure. The nine AOAs were catheterized from a contralateral femoral approach. Bilateral PAE was technically successful in the nine patients. There was a mean decrease in international prostate symptom score of 6.5 points and a mean prostate volume reduction of 15.1% (mean follow-up, 4.8 mo) in the nine patients

Evolutionary advantages of adaptive rewarding

Our wellbeing depends as much on our personal success, as it does on the success of our society. The realization of this fact makes cooperation a very much needed trait. Experiments have shown that rewards can elevate our readiness to cooperate, but since giving a reward inevitably entails paying a cost for it, the emergence and stability of such behavior remain elusive. Here we show that allowing for the act of rewarding to self-organize in dependence on the success of cooperation creates several evolutionary advantages that instill new ways through which collaborative efforts are promoted. Ranging from indirect territorial battle to the spontaneous emergence and destruction of coexistence, phase diagrams and the underlying spatial patterns reveal fascinatingly reach social dynamics that explains why this costly behavior has evolved and persevered. Comparisons with adaptive punishment, however, uncover an Achilles heel of adaptive rewarding that is due to over-aggression, which in turn hinders optimal utilization of network reciprocity. This may explain why, despite of its success, rewarding is not as firmly weaved into our societal organization as punishment.Comment: 14 pages, 8 figures; accepted for publication in New Journal of Physic

Effectiveness of Surgery for Lumbar Spinal Stenosis : A Systematic Review and Meta-Analysis

Peer reviewedPublisher PD

Omeprazole Impairs Vascular Redox Biology And Causes Xanthine Oxidoreductase-mediated Endothelial Dysfunction

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increased xanthine oxidoreductase (XOR) activity mediates PPIs-induced endothelial dysfunction (ED). We examined whether increased XOR activity impairs vascular redox biology and causes ED in rats treated with omeprazole. We also examined whether omeprazole aggravates the ED found in hypertension. Treatment with omeprazole reduced endothelium-dependent aortic responses to acetylcholine without causing hypertension. However, omeprazole did not aggravate two-kidney, one-clip (2KIC) hypertension, nor hypertension-induced ED. Omeprazole and 2K1C increased vascular oxidative stress as assessed with dihydroethidium (DHE), which reacts with superoxide, and by the lucigenin chemiluminescence assay. The selective XOR inhibitor febuxostat blunted both effects induced by omeprazole. Treatment with omeprazole increased plasma ADMA concentrations, XOR activity and systemic markers of oxidative stress. Incubation of aortic rings with ADMA increased XOR activity, DHE fluorescence and lucigenin chemiluminescence signals, and febuxostat blunted these effects. Providing functional evidence that omeprazole causes ED by XOR-mediated mechanisms, we found that febuxostat blunted the ED caused by omeprazole treatment. This study shows that treatment with omeprazole impairs the vascular redox biology by XOR-mediated mechanisms leading to ED. While omeprazole did not further impair hypertension-induced ED, further studies in less severe animal models are warranted. Our findings may have major relevance, particularly to patients with cardiovascular diseases taking PPIs. (C) 2016 The Authors. Published by Elsevier B.V.9134143Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014-23946-0]Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)CAPES (Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Magnetic Resonance Imaging Target Fusion Biopsy vs. Transrectal Ultrasound-Guided Biopsy - A Comparative Study of ISUP Score Upgrading Risk in the Final Radical Prostatectomy Specimen

Objectives: The aim of this study was to com-pare the risk of International Society of Urological Pathology (ISUP) score upgrading between magnetic resonance imaging targeted fusion biopsy (MRI-TB) and tran-srectal ultrasound-guided biopsy (TRUS-B) in the final radical prostatectomy (RP) specimen pathological report. Materials and methods: This retrospective single center study included 51 patients with prostate cancer (PCa) diagnosed with MRI-TB and 83 patients diagnosed with TRUS-B between October/2019 and July/2021. We compared the rates of ISUP score upgrading between both groups after robotic-assisted radi-cal prostatectomy (RARP) and the specific transition of each ISUP score based on biopsy modality. The rate of ISUP score concordance and downgrading were also assessed. To define the intra and interobserver concordance for each ISUP score in biopsy and RP specimen for each biopsy modality, the Cohen's Kappa coefficient was calculated. ISUP scores and biopsy modal-ity were selected for multivariate analysis and a logistic regres-sion model was built to provide independent risk factors of ISUP score upgrading. Results: The difference of the rate of upgrading between MRI-TB group and TRUS-B group was statistically significant (p = 0.007) with 42.2% of patients of TRUS-B group experiencing an upgrade in their ISUP score while only 19.6% in MRI-TB group. Concordance and downgrading rates did not statistically differ between the two groups. Strength of concordance using Cohen's Kappa coefficient was fair in both groups but higher in MRI-TB group (TRUS-B group k = 0.230; p < 0.001; concordance: 47%vs. MRI/TB group k = 0.438; p < 0.001; concordance: 62.7%). Biopsy modality and ISUP 1 on biopsy were independent predic-tors of ISUP upgrading after RP. Conclusions: MRI-TB is highly accurate with lower risk of PCa upgrading after RP than TRUS-B. Patients with ISUP 1 on biopsy have greater susceptibility to upgrading their ISUP score.info:eu-repo/semantics/publishedVersio

Systemic model for diagnosis of the micro, small and medium enterprises from two cities from the countryside of the state of São Paulo in Brazil

This article presents a proposal of a systemic model composed for the micro and small companies (MSE) of the region of Ribeirão Preto and the agents which influenced their environment. The proposed model was based on Stafford Beer's (Diagnosing the system for organizations. Chichester, Wiley, 1985) systemic methodologies VSM (Viable System Model) and on Werner Ulrich's (1983) CSH (Critical Systems Heuristics). The VSM is a model for the diagnosis of the structure of an organization and of its flows of information through the application of the cybernetics concepts (Narvarte, In El Modelo del Sistema Viable-MSV: experiencias de su aplicación en Chile. Proyecto Cerebro Colectivo del IAS, Santiago, 2001). On the other hand, CSH focus on the context of the social group applied to the systemic vision as a counterpoint to the organizational management view considered by the VSM. MSE of Ribeirão Preto and Sertãozinho had been analyzed as organizations inserted in systems that relate and integrate with other systems concerning the public administration, entities of representation and promotion agencies. The research questions: which are the bonds of interaction among the subsystems in this process and who are the agents involved? The systemic approach not only diagnosed a social group, formed by MSE of Ribeirão Preto and Sertãozinho, public authorities and support entities, but could also delineate answers that aimed the clarification of obscure questions generating financial assistance to the formularization of efficient actions for the development of this system. © 2009 Springer Science+Business Media, LLC