Rare lymphatic malformation of external ear canal with history of sclerotherapy

An 8-year-old boy with history of conductive hearing loss, presented with a 3.1 x 3.1 x 2 cm left postauricular mass diagnosed as lymphatic malformation on imaging. Treatment with bleomycin sclerotherapy led to successful improvement of the malformation. Seven months post-treatment, he presented to his audiologist with several months of intermittent bleeding and pain from the ear. Upon examination by otolaryngology, a 0.5 cm papillary lesion was discovered in the external ear canal which had not been identified previously. A biopsy demonstrated a papillary proliferation of dilated thin walled lymphatic channels expanding multiple dermal papillae, consistent with lymphatic malformation. We propose that this lesion could represent extension of the original lesion or a new lesion secondary to regional lymphatic damage from prior sclerotherapy. Lymphatic malformation is rare within the external ear canal. Moreover, this case developed after treatment by regional sclerotherapy. To our knowledge, this sequela has not been previously documented in the literature but may be underreported. Therefore, routine regional follow up may be warranted in any periauricular sclerotherapy for lymphatic malformation

Real-time Telepathology Is Substantially Equivalent to In-Person Intraoperative Frozen Section Diagnosis

CONTEXT.—: Intraoperative diagnosis by frozen section is a mainstay of surgical pathology practice, providing immediate feedback to the surgical team. Despite good accuracy with modern methods, access to intraoperative surgical pathology with an appropriate turnaround time (TAT) has been a limiting factor for small or remote surgical centers, with negative impacts on cost and patient care. Telepathology offers immediate expert anatomic pathology consultation to sites without an in-house or subspecialized pathologist. OBJECTIVE.—: To assess the utility of live telepathology in frozen section practice. DESIGN.—: Frozen section diagnoses by telemicroscopy from 2 tertiary care centers with combined 3 satellite hospitals were queried for anatomic site, TAT per block, pathologist, and concordance with paraffin diagnosis. TAT and concordance were compared to glass diagnoses in the same period. RESULTS.—: For 748 intraoperative diagnoses by telemicroscopy, 694 had TATs with a mean of 18 minutes 56 seconds ± 8 minutes 45 seconds, which was slower than on glass (14 minutes 25 seconds ± 7 minutes 8 seconds, P \u3c .001). Twenty-two (2.89% of available) were discordant, which was not significantly different from the on-glass rate (P = .44) or categorical distribution (P = .31). Two cases (0.27%) had technical failures. CONCLUSIONS.—: Although in-person diagnoses were statistically faster, the great majority of telemicroscopic diagnoses were returned in less than 20 minutes. This remained true through numerous pathologists, pathology assistants and/or technicians, different hospitals, and during a combined 6 years. The concentration of discordant diagnoses among relatively few pathologists suggests individual comfort with telepathology and/or frozen section diagnosis. In rare cases, technologic issues prevented telemicroscopic diagnosis. Overall, this justifies continued use and expansion of telemicroscopic services in primary intraoperative diagnoses

Perianal Pigmented Variant of Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma protuberans (DFSP) is a low-to-intermediate grade cutaneous sarcoma with reported at 3 per 1,000,000 individuals. It is a locally aggressive tumor which originates in the dermis and invades deeper structures. Up to 90% of cases of DFSP are associated with a translocation between chromosomes 17 and 22. These tumors have a high risk of local recurrence but very rarely exhibit metastatic spread. Several histologic variants exist, including fibrosarcomatous DFSP, and in this case, pigmented DSFP. Pigmented dermatofibrosarcoma protuberans, otherwise also known as a Bednar tumor, is a rare variant of DFSP first described in 1956 which accounts for less than 5% of all DSFP cases. It is distinguished by the presence of melanin containing dendritic cells within the tumor. Histologically, tumor cells are arranged in compact spindle shaped bundles. These tumors may be derived from neuroectodermal cells although no consensus has been reached. DSFP occurs equally in men and women and most commonly occurs in young to middle aged adults. These cutaneous sarcomas typically present on the trunk, back and shoulders as a slow-growing mass or plaque that may be hyperpigmented. Less that 1% present on genitalia, and only two DSFP cases to date have been reported involving the perianal region.https://scholarlycommons.henryford.com/merf2019caserpt/1085/thumbnail.jp

A Measure-Theoretic Characterization of Tight Language Models

Language modeling, a central task in natural language processing, involves estimating a probability distribution over strings. In most cases, the estimated distribution sums to 1 over all finite strings. However, in some pathological cases, probability mass can ``leak'' onto the set of infinite sequences. In order to characterize the notion of leakage more precisely, this paper offers a measure-theoretic treatment of language modeling. We prove that many popular language model families are in fact tight, meaning that they will not leak in this sense. We also generalize characterizations of tightness proposed in previous works.Comment: 25 pages; ACL 2023 camera read

Quantifying mechanical and metabolic interdependence between speed and propulsive force during walking

Walking speed is a useful surrogate for health status across the population. Walking speed appears to be governed in part by interlimb coordination between propulsive (FP) and braking (FB) forces generated during step-to-step transitions and is simultaneously optimized to minimize metabolic cost. Of those forces, FP generated during push-off has received significantly more attention as a contributor to walking performance. Our goal was to first establish empirical relations between FP and walking speed and then to quantify their effects on metabolic cost in young adults. To specifically address any link between FP and walking speed, we used a self-paced treadmill controller and real-time biofeedback to independently prescribe walking speed or FP across a range of condition intensities. Walking with larger and smaller FP led to instinctively faster and slower walking speeds, respectively, with ~80% of variance in walking speed explained by FP. We also found that comparable changes in either FP or walking speed elicited predictable and relatively uniform changes in metabolic cost, together explaining ~53% of the variance in net metabolic power and ~14% of the variance in cost of transport. These results provide empirical data in support of an interdependent relation between FP and walking speed, building confidence that interventions designed to increase FP will translate to improved walking speed. Repeating this protocol in other populations may identify other relations that could inform the time course of gait decline due to age and disease

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities †

Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis. The compounds were tested for antiparasitic activities against Leishmania major and Trypanosoma brucei, and for protease inhibition against several cysteine proteases such as falcipain, rhodesain, cathepsin L, cathepsin B, and viral proteases SARS-CoV Mpro, and PLpro. The compounds showed antiparasitic activities against T. brucei and time-dependent inhibition of cathepsin L-like proteases with Ki values in the low micromolar range

A corpus for large-scale phonetic typology

A major hurdle in data-driven research on typology is having sufficient data in many languages to draw meaningful conclusions. We present VoxClamantis v1.0, the first large-scale corpus for phonetic typology, with aligned segments and estimated phoneme-level labels in 690 readings spanning 635 languages, along with acoustic-phonetic measures of vowels and sibilants. Access to such data can greatly facilitate investigation of phonetic typology at a large scale and across many languages. However, it is non-trivial and computationally intensive to obtain such alignments for hundreds of languages, many of which have few to no resources presently available. We describe the methodology to create our corpus, discuss caveats with current methods and their impact on the utility of this data, and illustrate possible research directions through a series of case studies on the 48 highest-quality readings. Our corpus and scripts are publicly available for non-commercial use at https://voxclamantisproject.github.io.Comment: Accepted to ACL202

Ecology and diversity of culturable fungal species associated with soybean seedling diseases in the Midwestern United States

Aims: To isolate and characterize fungi associated with diseased soybean seedlings in Midwestern soybean production fields and to determine the influence of environmental and edaphic factors on their incidence. Methods and Results: Seedlings were collected from fields with seedling disease history in 2012 and 2013 for fungal isolation. Environmental and edaphic data associated with each field was collected. 3036 fungal isolates were obtained and assigned to 76 species. The most abundant genera recovered were Fusarium (73%) and Trichoderma (11.2%). Other genera included Mortierella, Clonostachys, Rhizoctonia, Alternaria, Mucor, Phoma, Macrophomina and Phomopsis. Most recovered species are known soybean pathogens. However, non-pathogenic organisms were also isolated. Crop history, soil density, water source, precipitation and temperature were the main factors influencing the abundance of fungal species. Conclusion: Key fungal species associated with soybean seedling diseases occurring in several US production regions were characterized. This work also identified major environment and edaphic factors affecting the abundance and occurrence of these species. Significance and Impact of the Study: The identification and characterization of the main pathogens associated with seedling diseases across major soybean-producing areas could help manage those pathogens, and devise more effective and sustainable practices to reduce the damage they cause

SCIPP: An Expanded Community of Practice - Community Publishing

SCIPP redefines and expands the existing notions about what makes for a vibrant and robust community of practice by partnering CSUSB students and professors with K-12 students, parents, and educators, along with committed community partners. SCIPP encourages curiosity in ways that leads to critical thinking, exploration, risk taking , confidence building, open-mindedness, and other personal traits that equip them with the softskills to be active, critical, and creative contributors to our communities. SCIPP pedagogy embraces our students\u27 collective wisdom and focuses on relational building where multi-directional communication is promoted and students are viewed as equal stakeholders in their own educations. SCIPP puts collaboration into action which in turn fosters community-based lifelong learning. SCIPP provides the open intellectual space for future university students (our K-12 students) to engage with existing university students in meaningful ways so as to sustain interconnected partnerships facilitating community engagement. It supports parents as experts in the education of their children and acknowledges parents as the first conduits to spark their children’s imagination while they actively participate in education enriching activities and programs. Everyone involved is committed to creating a secure and open atmosphere for dreaming, sharing, and learning. Together we explore the aspects of community publishing through collaborative learning in formal and informal settings relating to digital and printed medias