Funkcjonowanie fizyczne dzieci/ młodzieży po zakończeniu leczenia ostrej białaczki limfoblastycznej

The purpose of this paper is to evaluate the quality of life of children who have completed ALL treatment with respect to physical functioning as compared to healthy children of similar age.Materials and methods. The research was conducted among patients treated in the Chair and Clinic of Pediatrics, Hematology and Oncology of Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, who completed acute lymphoblastic leukemia treatment. It comprised children whose ALL treatment had finished at least 6 months prior to the research. The final group of patients who participated in the research consisted of 64 persons. Research referring to healthy children was carried out among students of primary schools, junior high schools and kindergartens throughout Bydgoszcz. Only children who had never undergone hospital treatment and did not suffer from chronic diseases were qualified for the said research. The comparative group included 70 healthy children. In order to evaluate the quality of life of children who had undergone ALL treatment and of healthy children James W. Varni’s standardized research instrument was used.Results. As far as children’s/adolescents’ subjective opinion is concerned, physical functioning was evaluated the lowest by adolescents aged 13-18. Pain and fatigue have a significant influence on lowering their quality of physical functioning. The highest evaluation of physical functioning was observed among patients aged 5-7. As far as indirect evaluation is concerned one can notice that physical functioning was evaluated the lowest by parents of children aged 13-18 and 2-4. While comparing physical functioning in both research groups major statistical differences in favour of the comparative group were noticed.Conclusion. The quality of life within the sphere of physical functioning of children and adolescents who have completed treatment is significantly lower than among healthy children.Celem pracy jest ocena jakości życia w sferze funkcjonowania fizycznego dzieci po zakończonym leczeniu ALL na tle zdrowej populacji w podobnym wieku.Materiał i metody. Badania przeprowadzono wśród pacjentów leczonych w Katedrze i Klinice Pediatrii, Hematologii i Onkologii Collegium Medicum Uniwersytetu Mikołaja Kopernika w Bydgoszczy, którzy zakończyli leczenie ostrej białaczki limfoblastycznej. Badaniami objęto dzieci, które zakończyły leczenie ALL przynajmniej 6 miesięcy przed badaniem. Ostateczna liczba osób, biorących udział w badaniu wynosiła 64.Badania wśród dzieci zdrowych przeprowadzono wśród uczniów szkoły podstawowej, gimnazjum oraz przedszkola na terenie Bydgoszczy. Do badania zakwalifikowano dzieci, które nigdy nie były poddane leczeniu szpitalnemu oraz nie chorują  na choroby przewlekłe. Grupę porównawczą stanowiło 70 dzieci zdrowych.Do oceny jakości życia dzieci po zakończonym leczeniu ALL oraz dzieci zdrowych użyto standaryzowanego narzędzia badawczego autorstwa Jamesa W. Varni.Wyniki. Funkcjonowanie fizycznew subiektywnym odczuciu dzieci/ młodzieży najniżej ocenione było przez grupę młodzieży w wieku od 13 do 18 lat. Istotny wpływ na obniżenie jakości funkcjonowania fizycznego ma u nich odczuwanie bólu oraz zmęczenia.Najwyżej oceniali funkcjonowanie fizyczne pacjenci w grupie 5-7 lat.W ocenie pośredniej najniższą wartość punktową funkcjonowania fizycznego uzyskano w grupie rodziców dzieci w wieku 13-18 lat oraz 2-4 lat. Porównując funkcjonowanie fizyczne w obu badanych grupach zauważono istotne statystycznie różnice na korzyść grupy porównawczej.Wniosek. Jakość życia w sferze funkcjonowania fizycznego dzieci i młodzieży po zakończonym leczeniu jest znamiennie niższa niż wśród dzieci zdrowych

catena-Poly[{μ-η5:η5-1-[2-(dimethyl­amino)­ethyl-κN]cyclo­penta­dien­yl}-lithium(I)-(μ-1,1,3,3-tetra-tert-butyl­triphosphane-κ3 P 2:P 1,P 3)lithium(I)]

The title compound, [Li2(C9H14N)(C16H36P3)]n, is a by-product of the reaction of [Cp(C5H4CH2CH2NMe2)ZrCl2]n with tBu2P–P(SiMe3)Li in toluene. It is a coordination polymer composed of infinite chains running along [010]. One Li(I) atom is chelated by the cyclo­penta­dienyl ring and and the N atom of the scorpionate ligand and a P atom, whereas the other Li(I) atom is coordinated by the backside of the cyclo­penta­dienyl ring and two P atoms. Both Li(I) atoms adopt a distorted trigonal coordination. The structure was determined from a twinned crystal, but only the data from the main twin component was used. The fraction of components in the crystal was 0.555:0.445 and the twin matrix corresponds to twofold rotation about the c axis (00/00/001)

catena-Poly[[(tetra­hydro­furan-κO)lithium(I)]-bis­(μ-trimethyl­silanolato-κ2 O:O)-gallium(III)-bis­(μ-trimethyl­silanolato-κ2 O:O)-[(tetra­hydro­furan-κO)lithium(I)]-μ-bromido]

The title chain polymer compound, [GaLi2Br(C3H9OSi)4(C4H8O)2]n, was obtained in the reaction of GaBr3 with Me3SiOLi in toluene/tetra­hydro­furan. The GaIII atom, located on a twofold rotation axis, is coordinated by four trimethyl­silanolate ligands and has a distorted tetra­hedral geometry. The LiI atom is four coordinated by one bridging Br atom located on an inversion centre, two trimethyl­silanolate ligands and one tetra­hydro­furane mol­ecule in a distorted tetra­hedral geometry. The polymeric chains extend along [001]. The tetra­hydro­furane mol­ecule is disordered over two positions with site-occupancy factors of 0.57 (2) and 0.43 (2)

Total Completion Time Minimization for Scheduling with Incompatibility Cliques

This paper considers parallel machine scheduling with incompatibilities between jobs. The jobs form a graph and no two jobs connected by an edge are allowed to be assigned to the same machine. In particular, we study the case where the graph is a collection of disjoint cliques. Scheduling with incompatibilities between jobs represents a well-established line of research in scheduling theory and the case of disjoint cliques has received increasing attention in recent years. While the research up to this point has been focused on the makespan objective, we broaden the scope and study the classical total completion time criterion. In the setting without incompatibilities, this objective is well known to admit polynomial time algorithms even for unrelated machines via matching techniques. We show that the introduction of incompatibility cliques results in a richer, more interesting picture. Scheduling on identical machines remains solvable in polynomial time, while scheduling on unrelated machines becomes APX-hard. Furthermore, we study the problem under the paradigm of fixed-parameter tractable algorithms (FPT). In particular, we consider a problem variant with assignment restrictions for the cliques rather than the jobs. We prove that it is NP-hard and can be solved in FPT time with respect to the number of cliques. Moreover, we show that the problem on unrelated machines can be solved in FPT time for reasonable parameters, e.g., the parameter pair: number of machines and maximum processing time. The latter result is a natural extension of known results for the case without incompatibilities and can even be extended to the case of total weighted completion time. All of the FPT results make use of n-fold Integer Programs that recently have received great attention by proving their usefulness for scheduling problems

1,1,2,2-Tetra­kis(diisopropyl­amino)diphosphane

In the title compound, C24H56N4P2, the distance between the P atoms [2.2988 (8) and 2.3013 (13) Å in the major and minor occupancy components, respectively] is one of the longest reported for uncoordinated diphosphanes. The whole mol­ecule is disordered over two positions with site-occupation factors of 0.6447 (8) and 0.3553 (8). The structure adopts the synperiplanar conformation in the solid state [N—P—P—N torsion angle = 14.7 (5)°]

5,5-Dimethyl-2-methyl­seleno-1,3,2-dioxaphospho­rinan-2-one

The title compound, C6H13O3PSe, was obtained in the reaction of 5,5-dimethyl-2-oxo-2-seleno-1,3,2-dioxaphospho­r­inane potassium salt with methyl iodide. The seleno­methyl group is in the axial position in relation to the six-membered dioxaphospho­rinane ring

2,4-Bis[bis(diisopropyl­amino)­phos­phanyl]-1,2,3,4-tetra­phospha­bicyclo[1.1.0]butane

The title compound, C24H56N4P6 or (iPr2N)2P–P4–P(NiPr2)2, adopts a butterfly structure, with planar environments for the N atoms and pyramidal environments for the P atoms. The structure studied has a 15% twin component that is related by a twofold rotation about [100]

Propuesta de intervención en el Cuarto Real de Santo Domingo (Granada)

El Cuarto Real de Santo Domingo en Granada es, -en palabras de los autores de este artículo-, el edificio clave para el análisis de la arquitectura y la decoración en la transición del arte postalmohade al nazarí. Es de destacar el rigor de la investigación, la minuciosidad de los levantamientos gráficos mediante técnicas taquimétricas y fotogramétricas, así como la apuesta comprometida contenida en la propuesta de liberación y de repristinación que incluye la alberca y el jardín.Ayuntamiento de GranadaPeer reviewe

Dispiro­[cyclo­propane-1,5′-endo-tricyclo­[5.2.1.02,6]deca-3,8-diene-10′,1′′-cyclo­propane]

The title compound, C14H16, is built up from three five-membered rings. Two of the five-membered rings display an envelope conformation and the third one is almost planar (r.m.s. deviation = 0.014 Å)

Chlorido(η5-cyclo­penta­dien­yl)[(4a,4b,8a,9,9a-η)-fluoren­yl](fluorenyl-κC 9)zirconium(IV) toluene solvate

In the title compound, [Zr(C5H5)(C13H9)2Cl]·C7H8, the ZrIV atom is coordinated by a Cl atom, a cyclo­penta­dienyl (Cp) ligand [Zr–centroid (Cp) = 2.199 (3) Å] and two fluorenyl ligands (Fl) [Zr–centroid (Fl) = 2.273 (2) Å and Zr—CH from fluorenyl = 2.355 (2) Å] in a distorted tetra­gonal geometry. The dihedral angles between the mean planes of the fluorenyl ring systems and the Cp ring are 36.62 (6)° for the η1-coordinated fluorenyl and 52.85 (6)° for the η5-coordinated fluorenyl, while the dihedral angle between the mean planes of the two fluorenyl ring systems is 76.18 (7)°