The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells. This research was supported by a grant from GW Pharmaceuticals to M. G. C. and R. G. P.Peer reviewedPostprin

The Future Ready Ideas Lab : Future Proofing Bioscience Students Enterprise Skills

Peer reviewedPublisher PD

Autonomy, Social Interactions and Culture

The present paper, using a social interactions model, studies the impact of culture on autonomy of immigrants. The results suggest that: (i) immigrants' autonomy is largely influenced by the autonomy of individuals living in a host country; (ii) some immigrants are better off in countries and regions with better institutional environments. The results are robust to sensitivity checks. The contributions of the paper are as follows. First, we estimate a social interactions model that models both the formation of social interactions and the sorting of individuals to study the impact of culture on individual autonomy. Second, we estimate a model that analyzes the impact of both confidence in the individual and collective culture on individuals' decisions. Finally, since this is an observational learning model, policy suggestions may be drawn from the analysis

Revolução na América Latina nos anos 1980: estratégia e táticas

O artigo em questão traduz do inglês para o português uma transcrição de fala de Ruy Mauro Marini durante uma conferência em Ontario Institute for Studies in Education. Trata-se de uma exposição sobre o processo revolucionário na América Latina e algumas perspectivas a respeito que Ruy Mauro Marini nos trouxe em sua época, contrapondo reformismo e revolução. Marini também traz perspectivas sobre os movimentos sociais presentes nos anos 1980, com destaque para os processos revolucionários na América Central. Ao fim, o sociólogo mineiro responde algumas perguntas da plateia sobre o futuro do socialismo latino-americano

Integration of an increasing-fidelity aerodynamic modelling approach in the conceptual design of hypersonic cruiser

This paper deals with the integration of an increasing-fidelity aerodynamic modelling approach in the conceptual design of hypersonic cruiser. At this purpose, a dedicated methodology has been developed in the framework of the H2020 STRATOFLY project and applied to the STRATOFLY MR3, the Mach 8 waverider reference configuration. Considering the complexity of the concept to be analyzed at conceptual/preliminary design stage, a build-up approach has been adopted, incrementally increasing the complexity of the aerodynamic model, from the clean external configuration up to the complete configuration, including Propulsion Systems Elements and Flight Control Surfaces. In parallel to the aerodynamic analysis, detailed Mission Analyses are performed at each step, benefitting of the incremental versions of the Aerodynamic Database which are used as input. The application of the entire methodology to the reference case-study, allows to estimate design margins to be used at the different steps, to avoid unsolicited under/over-estimations of fuel mass and ranges

Analysis of Forming Parameters Involved in Plastic Deformation of 441 Ferritic Stainless Steel Tubes

A welded stainless steel tube is a component used in several industrial applications. Its manufacturing process needs to follow specific requirements based on reference standards. This calls for a predictive analysis able to face some critical issues affecting the forming process. In this paper, a model was adopted taking into account the tube geometrical parameters that was able to describe the deformation process and define the best industrial practices. In this paper, the effect of different process parameters and geometric constraints on ferritic stainless steel pipe deformation is studied by finite element method (FEM) simulations. The model sensitivity to the input parameters is reported in terms of stress and tube thinning. The feasibility of the simulated process is assessed through the comparison of Forming Limit Diagrams. The comparison between the calculated and experimental results proved this approach to be a useful tool in order to predict and properly design industrial deformation processes

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

Acknowledgements These studies were funded by a Wellcome Trust (105625/Z/14/Z) ISSF starting grant, Medical Research Scotland (PhD-719-2013) and GW Pharmaceuticals (PhD-719-2013 - S.5242.001).Peer reviewedPublisher PD

Radio hyperthermia for re-treatment of superficial tumours.

Relapse remains an unsolved problem for previously radio-treated patients. Our purpose is to evaluate the role of radio-hyperthermia (RT-HT) in the retreatment of superficial recurrences.From 1998 to 2007, 51 patients affected by four histological types (breast recurrences (group A), melanoma recurrences (group B), head and neck recurrences (group C), and others (group D)) of 76 superficial lesions, were enrolled at Mauriziano Hospital at the Research Institute of Cancer Care Candiolo (IRCC) in Turin. All patients had previously undergone RT except 6 patients of group B. The total mean retreatment dose was 31.8 Gy (20-60 Gy), while the mean of HT sessions was 5 (1 to 8), temperature ranged from 38.5 degrees C (T min) to 44 degrees C (T max).Acute cutaneous toxicity was 77.6% G1, 22.4% G2, none for G3. Forty-five days later we observed: for group A 65.9% complete response (CR), 29.5% partial response (PR), 4.5% non-response (NR); for group B 33.3% CR, 25% PR and 41.7% NR; for group C 40% CR, 13.3% PR, 46.7% NR, for group D 60% CR and 40% NR. 18 months later group A presented 72.7% local control (LC), 20.5% stable disease (SD) and 6.8% non-control (NC), group B 50% LC, 16,7% SD and 33.3% NC, group C 33.3% LC, 40% SD and 26.7% NC, group D 40% LC and 60% NC. Early response, size of lesionsor =3 cm, T maxor =42 degrees C and RT dosesor =40 Gy were predictive outcome factors.We confirmed that radio-hyperthermia is useful in re-irradiation with a very high patient compliance