measuring the magic of public space le piazze di roma

The concept of public space, and particularly of civic public space, is certainly a constitutive element of Italy's urban culture. The design and spatial configuration of public spaces have always been a synthesis between deeply rooted models and political functions (the piazza, the palazzo, the church, the civic buildings), and of local circumstances and design inspiration. Hence the fascination of the piazza: while all piazze perform similar functions, they take very different spatial and architectural characteristics, thus adding to the variety and the "magic", as it were, of public space experience.The main purpose of this article is to celebrate the piazza as the core symbol of public space magic. In doing so, I set a modest linguistic goal: to discourage non-Italian speaking piazza fans from using the plural "piazzas" and to impose the Italian "piazze". As to the success of this endeavour, only future will tell.</p

the biennial of public space in rome from the charter of public space to the post habitat iii agenda

The fourth Biennial of Public Space (BISP 2017 – http://www.biennalespaziopubblico.it/) will be held in Rome on May 25-27th, at University of Roma TRE, Testaccio neighbourhood. It will be the first one held after the adoption of the Sustainable Development Goals and the New Urban Agenda. Therefore, it will have the opportunity to take stock of the challenges the two events posed to city dwellers, civil society and policy makers.If it will limit itself to parading good practices and admirable projects it will miss this opportunity. However, the intention is to lend an attentive ear, as always, to the work of international agencies and organizations. In fact, one of the preparatory activities proposed is to activate a dialogue paying special attention to the role that local governments and an efficient and responsible public sector can perform in addressing the SDG Public Space Target, and their unique civic responsibility and development potential: policies and planning. Unless this role is explored and enabled, it is highly unlikely that the SDG public space target will be achieved simply relying on civil society initiatives, isolated good practices and spirited performances.</p

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09

Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05 and HLAB*27:09. Thus, the objective of this study was to compare the formation of β2m-free heavy chain (FHC) including B27 dimers (B272) by HLA-B*27:05 and HLA-B*27:09 and their binding to KIR immunoreceptors. Methods. We studied the formation of HLA-B*27:05 and HLA-B*27:09 heterotrimers and FHC forms including dimers in vitro and in transfected cells. We investigated HLA-B*27:05 and HLA-B*27:09 binding to KIR3DL1, KIR3DL2 and LILRB2 by FACS staining with class I tetramers and by quantifying interactions with KIR3DL2CD3ε-reporter cells and KIR3DL2-expressing NK cells. We also measured KIR expression on peripheral blood NK and CD4 T cells from 18 HLA-B*27:05 AS patients, 8 HLA-B27 negative and 12 HLA-B*27:05+ and HLA-B*27:09+ healthy controls by FACS staining. Results. HLA-B*27:09 formed less B272 and FHC than HLA-B*27:05. HLA-B*27:05-expressing cells stimulated KIR3DL2CD3ε-reporter T cells more effectively. Cells expressing HLA-B*27:05 promoted KIR3DL2+ NK cell survival more strongly than HLA-B*27:09. HLA-B*27:05 and HLA-B*27:09 dimer tetramers stained KIR3DL1, KIR3DL2 and LILRB2 equivalently. Increased proportions of NK and CD4 T cells expressed KIR3DL2 in HLA-B*27:05+ AS patients compared with HLA-B*27:05+, HLA-B*27:09+ and HLA-B27− healthy controls. Conclusion. Differences in the formation of FHC ligands for KIR3DL2 by HLA-B*27:05 and HLA-B*27:09 could contribute to the differential association of these alleles with A

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Measuring the Magic of Public Space. Le Piazze di Roma

The concept of public space, and particularly of civic public space, is certainly a constitutive element of Italy's urban culture. The design and spatial configuration of public spaces have always been a synthesis between deeply rooted models and political functions (the piazza, the palazzo, the church, the civic buildings), and of local circumstances and design inspiration. Hence the fascination of the piazza: while all piazze perform similar functions, they take very different spatial and architectural characteristics, thus adding to the variety and the "magic", as it were, of public space experience.The main purpose of this article is to celebrate the piazza as the core symbol of public space magic. In doing so, I set a modest linguistic goal: to discourage non-Italian speaking piazza fans from using the plural "piazzas" and to impose the Italian "piazze". As to the success of this endeavour, only future will tell.</p

The Biennial of Public Space in Rome. From the Charter of Public Space to the Post-Habitat III Agenda

The fourth Biennial of Public Space (BISP 2017 – http://www.biennalespaziopubblico.it/) will be held in Rome on May 25-27th, at University of Roma TRE, Testaccio neighbourhood. It will be the first one held after the adoption of the Sustainable Development Goals and the New Urban Agenda. Therefore, it will have the opportunity to take stock of the challenges the two events posed to city dwellers, civil society and policy makers.If it will limit itself to parading good practices and admirable projects it will miss this opportunity. However, the intention is to lend an attentive ear, as always, to the work of international agencies and organizations. In fact, one of the preparatory activities proposed is to activate a dialogue paying special attention to the role that local governments and an efficient and responsible public sector can perform in addressing the SDG Public Space Target, and their unique civic responsibility and development potential: policies and planning. Unless this role is explored and enabled, it is highly unlikely that the SDG public space target will be achieved simply relying on civil society initiatives, isolated good practices and spirited performances.</p

Contingent Matemathics of Nature in the Renaissance: Cusanus’ Perspective

The transition from the natural philosophies of the Renaissance to seventeenth-century physics was marked by an epistemological shift. On the one hand, Renaissance natural philosophers and scientists assumed that a certain degree of imperfection in the natural phenomena is necessary. In fact, according to Cusanus’s expressions in De docta ignorantia, formal necessitas and material possibilitas are combined in nature through a dynamical nexus, in agreement with what we will designate as the “principle of contingency of Renaissance natural philosophy”. This principle of “insufficient reason” underlies the outlook of an entire epoch, as is witnessed by philosophies of nature close to that of Cusanus, for instance by Giordano Bruno. On the other hand, late seventeenth-century physics became dominated by the idea of a necessary connection of the phenomena. Accordingly, any natural phenomenon was understandable in the light of the principle of sufficient reason. In this paper, we intend to focus on Cusanus’s natural philosophy and conception of mathematics in order to show how this transition form a contingent to a necessary conception of natural phenomena emerged