124 research outputs found
DC-powered Fe3+:sapphire Maser and its Sensitivity to Ultraviolet Light
The zero-field Fe3+:sapphire whispering-gallery-mode maser oscillator
exhibits several alluring features: Its output is many orders of magnitude
brighter than that of an active hydrogen maser and thus far less degraded by
spontaneous-emission (Schawlow-Townes) and/or receiving-amplifier noise. Its
oscillator loop is confined to a piece of mono-crystalline rock bolted into a
metal can. Its quiet amplification combined with high resonator Q provide the
ingredients for exceptionally low phase noise. We here concentrate on novelties
addressing the fundamental conundrums and technical challenges that impede
progress. (1) Roasting: The "mase-ability" of sapphire depends significantly on
the chemical conditions under which it is grown and heat-treated. We provide
some fresh details and nuances here. (2) Simplification: This paper obviates
the need for a Ka-band synthesizer: it describes how a 31.3 GHz loop
oscillator, operating on the preferred WG pump mode, incorporating Pound
locking, was built from low-cost components. (3) "Dark Matter": A Siegman-level
analysis of the experimental data determines the substitutional concentration
of Fe3+ in HEMEX to be less than a part per billion prior to roasting and up to
a few hundred ppb afterwards. Chemical assays, using different techniques
(incl. glow discharge mass spectra spectroscopy and neutron activation
analysis) consistently indicate, however, that HEMEX contains iron at
concentrations of a few parts per million. Drawing from several
forgotten-about/under-appreciated papers, this substantial discrepancy is
addressed. (4) Excitons: Towards providing a new means of controlling the
Fe3+:sapph. system, a cryogenic sapphire ring was illuminated, whilst masing,
with UV light at wavelengths corresponding to known electronic and
charge-transfer (thus valence-altering) transitions. Preliminary experiments
are reported.Comment: pdf only; submitted to the proceedings of the 24th European Frequency
and Time Forum, 13-15th April, 201
Influence of the ESR saturation on the power sensitivity of cryogenic sapphire resonators
Here, we study the paramagnetic ions behavior in presence of a strong
microwave electromagnetic field sustained inside a cryogenic sapphire
whispering gallery mode resonator. The high frequency measurement resolution
that can be now achieved by comparing two CSOs permit for the first time to
observe clearly the non-linearity of the resonator power sensitivity. These
observations that in turn allow us to optimize the CSO operation, are well
explained by the Electron Spin Resonance (ESR) saturation of the paramagnetic
impurities contained in the sapphire crystal.Comment: 8 pages, 9 figure
Compact Yb optical atomic clock project: design principle and current status
We present the design of a compact optical clock based on the 435.5 nm transition in Yb. The ion trap will
be based on a micro-fabricated circuit, with surface electrodes generating a
trapping potential to localize a single Yb ion a few hundred m from the
electrodes. We present our trap design as well as simulations of the resulting
trapping pseudo-potential. We also present a compact, multi-channel wavelength
meter that will permit the frequency stabilization of the cooling, repumping
and clear-out lasers at 369.5 nm, 935.2 nm and 638.6 nm needed to cool the ion.
We use this wavelength meter to characterize and stabilize the frequency of
extended cavity diode lasers at 369.5 nm and 638.6 nm.Comment: 7 pages, 5 figures. Proc. of the 8th FSM 2015, Potsdam, Germany. To
be published in IOP Journal of Physics: Conference Serie
Creating traveling waves from standing waves from the gyrotropic paramagnetic properties of Fe ions in a high-Q whispering gallery mode sapphire resonator
We report observations of the gyrotropic change in magnetic susceptibility of
the Fe electron paramagnetic resonance at 12.037GHz (between spin states
and ) in sapphire with respect to applied magnetic field.
Measurements were made by observing the response of the high-Q Whispering
Gallery doublet (WGH) in a Hemex sapphire resonator cooled to 5
K. The doublets initially existed as standing waves at zero field and were
transformed to traveling waves due to the gyrotropic response.Comment: Accepted for publication in Phys. Rev.
Measurement of fundamental thermal noise limit in a cryogenic sapphire frequency standard using bimodal maser oscillations
We report observations of the Schawlow-Townes noise limit in a cryogenic
sapphire secondary frequency standard. The effect causes a fundamental limit to
the frequency stability, and was measured through the novel excitation of a
bimodal maser oscillation of a Whispering Gallery doublet at . The
beat frequency of between the oscillations enabled a sensitive probe
for this measurement of fractional frequency instability of
with only 0.5 of output power.Comment: Published in PRL 100, 233901 (2008
Detection of quantitative trait loci for growth and fatness in pigs
A quantitative trait locus (QTL) analysis of growth and fatness data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six boars and 23 F1 sows, the progeny of six LW boars and six MS sows, produced 530 F2 males and 573 F2 females. Nine growth traits, i.e. body weight at birth and at 3, 10, 13, 17 and 22 weeks of age, average daily gain from birth to 3 weeks, from 3 to 10 weeks and from 10 to 22 weeks of age, as well as backfat thickness at 13, 17 and 22 weeks of age and at 40 and 60 kg live weight were analysed. Animals were typed for a total of 137 markers covering the entire porcine genome. Analyses were performed using two interval mapping methods: a line-cross (LC) regression method where founder lines were assumed to be fixed for different QTL alleles and a half-/full-sib (HFS) maximum likelihood method where allele substitution effects were estimated within each half-/full-sib family. Both methods revealed highly significant gene effects for growth on chromosomes 1, 4 and 7 and for backfat thickness on chromosomes 1, 4, 5, 7 and X, and significant gene effects on chromosome 6 for growth and backfat thickness. Suggestive QTLs were also revealed by both methods on chromosomes 2 and 3 for growth and 2 for backfat thickness. Significant gene effects were detected for growth on chromosomes 11, 13, 14, 16 and 18 and for backfat thickness on chromosome 8, 10, 13 and 14. LW alleles were associated with high growth rate and low backfat thickness, except for those of chromosome 7 and to a lesser extent early-growth alleles on chromosomes 1 and 2 and backfat thickness alleles on chromosome 6
GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients
International audienceGenetic polymorphisms are associated with breast cancer risk. Clinical and epidemiological observations suggest that clinical characteristics of breast cancer, such as estrogen receptor or HER2 status, are also influenced by hereditary factors. To identify genetic variants associated with pathological characteristics of breast cancer patients, a Genome Wide Association Study was performed in a cohort of 9365 women from the French nationwide SIGNAL/PHARE studies (NCT00381901/RECF1098). Strong association between the FGFR2 locus and ER status of breast cancer patients was observed (ER-positive n=6211, ER-negative n=2516; rs3135718 OR=1.34 p=5.46x10-12). This association was limited to patients with HER2-negative tumors (ER-positive n=4267, ER-negative n=1185; rs3135724 OR=1.85 p=1.16x10-11). The FGFR2 locus is known to be associated with breast cancer risk. This study provides sound evidence for an association between variants in the FGFR2 locus and ER status among breast cancer patients, particularly among patients with HER2-negative disease. This refinement of the association between FGFR2 variants and ER-status to HER2-negative disease provides novel insight to potential biological and clinical influence of genetic polymorphisms on breast tumors
Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort
BACKGROUND:
Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice.
METHODS:
A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively.
RESULTS:
SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655.
CONCLUSIONS:
In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin
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