Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future.

PURPOSE: Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. DESIGN: Meta-analysis of prevalence data. PARTICIPANTS: A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. METHODS: AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). MAIN OUTCOME MEASURES: Prevalence of early and late AMD, BCVA, and number of AMD cases. RESULTS: Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%-5.0%) in those aged 55-59 years to 17.6% (95% CI 13.6%-21.5%) in those aged ≥85 years; for late AMD these figures were 0.1% (95% CI 0.04%-0.3%) and 9.8% (95% CI 6.3%-13.3%), respectively. We observed a decreasing prevalence of late AMD after 2006, which became most prominent after age 70. Prevalences were similar for gender across all age groups except for late AMD in the oldest age category, and a trend was found showing a higher prevalence of CNV in Northern Europe. After 2006, fewer eyes and fewer ≥80-year-old subjects with CNV were visually impaired (P = 0.016). Projections of AMD showed an almost doubling of affected persons despite a decreasing prevalence. By 2040, the number of individuals in Europe with early AMD will range between 14.9 and 21.5 million, and for late AMD between 3.9 and 4.8 million. CONCLUSION: We observed a decreasing prevalence of AMD and an improvement in visual acuity in CNV occuring over the past 2 decades in Europe. Healthier lifestyles and implementation of anti-vascular endothelial growth factor treatment are the most likely explanations. Nevertheless, the numbers of affected subjects will increase considerably in the next 2 decades. AMD continues to remain a significant public health problem among Europeans

Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future

Purpose Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. Design Meta-analysis of prevalence data. Participants A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. Methods AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). Main Outcome Measures Prevalence of early and late AMD, BCVA, and number of AMD cases. Results Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%–5.0%) in those aged 55–59 years to 17.6% (95%

TECNICHE DI DIGITALIZZAZIONE DELLE IMMAGINI APPLICATE ALLO S.L.O

ATTI DEL 10\uc2\ub0 CONVEGNO S.O.

LA RETINOPATIA DA RADIAZIONI

ESTRATTO DAGLI ATTI DEL LXIII CONGRESSO S.O.

Uveal lymphoid infiltration: clinical, angiographic and cytological aspects.

Purpose: To report the clinical, angiographic and cytological features of uveal lymphoid infiltration diagnosed by orbital fine needle aspiration biopsy of orbital nodules. Methods: Three patients (2 males, 1 female) affected by suspected uveal lymphoid infiltration and simultaneous orbital nodules underwent fine needle aspiration biopsy of orbital lesions. Flu- orescein and indocyanine green (ICG) angiography were .also performed before and after therapy. Results: Cytological specimens from orbital masses documented B lymphocytes and plasmacytoid cells in all cases. ICG angiography demonstrated the infiltration of choroi- dal lobules. Uveal and orbital infiltrates slowly disappeared after radiotherapy. ICG angiog- raphy documented the resolution of neoplastic choroidal infiltration. Conclusions: Uveal lymphoid infiltration is a rare clinical condition difficult to diagnose. Fine needle aspiration biopsy of simultaneous orbital nodules may give enough material to confirm clinical diagno- sis. CR: Non

Idiopathic retinal vasculitis

Monografia di 512 p

Membrane neovascolari idiopatiche extramaculari

ANNO 73 N.

TECNICA DI PREPARAZIONE DI COLTURE CELLULARI PRIMARIE IN MONOSTRATO DI EPITELIO PIGMENTATO RETINICO DA CONIGLIO NEONATO

L'epitelio pigmentato retinico (EPR) rappresenta un costituente fondamentaled ella retinad i mammifero. Una delle sue principali funzioni sembra sia quella di fagocitare i segmentei sternid i coni e bastoncelli al fine di garantire un adeguato rinllovamento dei fotorecettori (l). A1- tre azioni riguardanti il metabolismo ed il trasporto della vitamina A sono state descritte da numerosi Autori (2), ma la difficoltà di ottenere quantità apprezzabili di materiale sperimentale" in vivo", ed " in vitro " rende le notizie in merito largamente incomplete. N el presente lavoro esponiamo un metodo semplice per allestire colture cellulari primarie di EPR di coniglio neonato, in grado di fornire un modello sperimentalmente valido per lo studio dei suoi aspetti metabolici

ARTIFICIAL DIVERGENCE OPERATION IN A CASE OF CONGENITAL NYSTAGMUS WITH CONVERGENCE NULL

The case of a child with pendular nystagmus and convergence null is reported