Einführung und Optimierung eines praxisorientierten Problem-based-Learning-Moduls im Life-Science-Bereich

Der vorliegende Beitrag soll zur Diskussion rund um effektive Lehrkonzepte unter Anwendung des Problem-based-Learning-Ansatzes beitragen. Anhand eines konkreten Beispiels aus dem Life-Science-Bereich Tissue Engineering werden zunächst Herausforderungen in der Einführungsphase eines PBL-Moduls beleuchtet. Anschließend werden das aktuelle Konzept des Moduls, die vorgenommenen Maßnahmen zur Optimierung während dessen kontinuierlicher Weiterentwicklung sowie deren Wirksamkeit aus Sicht der Studierenden dargestellt. 13.05.2016 | Christine Leeb, Rita Leitner, Verena Pichler, Carina Huber-Gries, Dominik Rünzler & Veronika Jesenberger (Wien

Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry

Introduction: COVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. Methods: This study reports on 986 patients reported to the EBMT registry during the first 29 months of the pandemic. Results: The median age was 50.3 years (min – max; 1.0 – 80.7). The median time from most recent HCT to diagnosis of COVID-19 was 20 months (min – max; 0.0 – 383.9). The median time was 19.3 (0.0 - 287.6) months during 2020, 21.2 (0.1 - 324.5) months during 2021, and 19.7 (0.1 – 383.9) months during 2022 (p = NS). 145/986 (14.7%) patients died; 124 (12.6%) due to COVID-19 and 21 of other causes. Only 2/204 (1%) fully vaccinated patients died from COVID-19. There was a successive improvement in overall survival over time. In multivariate analysis, increasing age (p<.0001), worse performance status (p<.0001), contracting COVID-19 within the first 30 days (p<.0001) or 30 – 100 days after HCT (p=.003), ongoing immunosuppression (p=.004), pre-existing lung disease (p=.003), and recipient CMV seropositivity (p=.004) had negative impact on overall survival while patients contracting COVID-19 in 2020 (p<.0001) or 2021 (p=.027) had worse overall survival than patients with COVID-19 diagnosed in 2022. Discussion: Although the outcome of COVID-19 has improved, patients having risk factors were still at risk for severe COVID-19 including death