Estimating The Costs And Cost-effectiveness Of Promoting Mammography Screening Among US-based Latinas

Purpose: We characterize the costs and cost-effectiveness of a community health worker (CHW)-based intervention to promote screening mammography among US-based non-adherent Latinas. Methods: The parent study was a randomized controlled trial for 536 Latinas aged 42-74 years old who had sought care within a safety net health center in Western Washington. Participants were block-randomized within clinic to the control arm (usual care) or intervention arm (CHW-led motivational interviewing intervention). We used the perspective of the organization implementing promotional activities to characterize costs and cost-effectiveness. Cost data were categorized as program set-up and maintenance (initial training, booster/annual training) program implementation (administrative activities, intervention delivery); and, overhead/miscellaneous expenses. Cost-effectiveness was calculated as the incremental cost of screening for each additional woman screened between the intervention and control arms. Results: The respective costs per participant for standard care and the intervention arm were $69.96 and$300.99. There were no study arm differences in 1-year QALYs among women who completed a 12-month follow-up survey (intervention= 0.8827, standard care = 0.8841). Most costs pertained to program implementation and administrative activities specifically. The incremental cost per additional woman screened was $2,595.32. Conclusions: Our findings are within the ranges of costs and cost-effectiveness for other CHW programs to promote screening mammography among underserved populations. Our strong study design and focus on non-adherent women provides important strengths to this body of work, especially give implementation and dissemination science efforts regarding CHW-based health promotion for health disparity populations

Contrast Enhancement of Optical Coherence Tomography Images Using Branched Gold Nanoparticles

We propose the use of branched gold nanoparticles (B-GNPs) as a contrast agent for optical coherence tomography (OCT) imaging. Our results show that even when the central source of our OCT (1325 nm) is too far from the maximum peak of the plasmon resonance, branched nanoparticles scatter light very efficiently at this wavelength. B-GNPs were tested as a contrast agent in water and agarose-TiO2 tissue phantoms; the estimated increments in contrast were 9.19 dB and 15.07 dB for branched nanoparticles in water with concentrations of 2.2×109 NPs/mL and 6.6×109 NPs/mL, respectively, while for agarose-TiO2 tissue phantoms the estimated value was 3.17 dB. These results show the promising application of B-GNPs as a contrast agent for tissue imaging using OCT, not only for sources at 1325 nm but also at other central wavelengths located between 800 and 1000 nm

A candidate magnetic helium core white dwarf in the globular cluster NGC 6397

We report a peculiar variable blue star in the globular cluster NGC 6397, using Hubble Space Telescope optical imaging. Its position in the colour-magnitude diagrams, and its spectrum, are consistent with this star being a helium core white dwarf (He WD) in a binary system. The optical light curve shows a periodicity at 18.5 hours. We argue that this periodicity is due to the rotation of the WD and possibly due to magnetic spots on the surface of the WD. This would make this object the first candidate magnetic He WD in any globular cluster (GC), and the first candidate magnetic WD in a detached binary system in any GC and one of the few He WDs with a known rotation period and of magnetic nature. Another possibility is that this system is a He WD in a binary system with another WD or another degenerate object, which would make this object one of the few candidate non-accreting double degenerate binaries in any GC.Comment: Accepted for publication in MNRA

Relación de la economía personal con el perfil de felicidad y satisfacción de vida y el perfil de preocupaciones personales en Andalucía (España) / Relationship of the personal economy with the profile of happiness and life satisfaction and the profile of personal concerns in Andalusia (Spain)

Desde hace unos años, se ha intensificado la necesidad de evaluar la sociedad colocando en el centro a las personas y considerando como objetivos la felicidad, la satisfacción de vida y sus preocupaciones personales. En este trabajo, se analiza la relación de la valoración de la situación económica personal con la satisfacción con la vida (en general y diversos aspectos como trabajo, formación, familia, etc.), con el índice de felicidad y con los grados de preocupación con diversos aspectos personales y del entorno cercano a partir de una encuesta realizada en Andalucía en 2018.  Para ello, además del análisis de las correlaciones bivariadas, se procede a aplicar modelos de regresión logística ordinal que permitan explicar las relaciones de los distintos indicadores personales de satisfacción, felicidad y preocupaciones con la valoración de la situación económica personal en la actualidad y las perspectivas futuras, ambas diseñadas como variables ordinales

Relationship of the personal economy with the profile of happiness and life satisfaction and the profile of personal concerns in Andalusia (Spain)

Desde hace unos años, se ha intensificado la necesidad de evaluar la sociedad colocando en el centro a las personas y considerando como objetivos la felicidad, la satisfacción de vida y sus preocupaciones personales. En este trabajo, se analiza la relación de la valoración de la situación económica personal con la satisfacción con la vida (en general y diversos aspectos como trabajo, formación, familia, etc.), con el índice de felicidad y con los grados de preocupación con diversos aspectos personales y del entorno cercano a partir de una encuesta realizada en Andalucía en 2018. Para ello, además del análisis de las correlaciones bivariadas, se procede a aplicar modelos de regresión logística ordinal que permitan explicar las relaciones de los distintos indicadores personales de satisfacción, felicidad y preocupaciones con la valoración de la situación económica personal en la actualidad y las perspectivas futuras, ambas diseñadas como variables ordinales.In recent years, the need to evaluate society has intensified, placing people at the center and considering happiness, life satisfaction and their personal concerns as objectives. In this work, the influence of life satisfaction (in general and various aspects such as work, training, family, etc.), the happiness index and the degrees of personal concern on the assessment of the personal economic situation are analyzed. The analysis has been developed using data from a survey conducted in Andalusia in 2018. In addition to the analysis of the bivariate correlations, ordinal logistic regression models are applied to explain the relationships of the different personal indicators of satisfaction, happiness and concerns with the assessment of the personal economic situation at present and future perspectives, both designed as ordinal variables

Open clusters towards the Galactic center: chemistry and dynamics. A VLT spectroscopic study of NGC6192, NGC6404, NGC6583

In the framework of the study of the Galactic metallicity gradient and its time evolution, we present new high-resolution spectroscopic observations obtained with FLAMES and the fiber link to UVES at VLT of three open clusters (OCs) located within $\sim$7~kpc from the Galactic Center (GC): NGC~6192, NGC~6404, NGC~6583. We also present new orbit determination for all OCs with Galactocentric distances (R$_{\rm{GC}}) \leq$8~kpc and metallicity from high-resolution spectroscopy. We aim to investigate the slope of the inner disk metallicity gradient as traced by OCs and at discussing its implication on the chemical evolution of our Galaxy. We have derived memberships of a group of evolved stars for each clusters, obtaining a sample of 4, 4, and 2 member stars in NGC~6192, NGC~6404, and NGC~6583, respectively. Using standard LTE analysis we derived stellar parameters and abundance ratios for the iron-peak elements Fe, Ni, Cr, and for the $\alpha$-elements Al, Mg, Si, Ti, Ca. We calculated the orbits of the OCs currently located within 8~kpc from the GC, and discuss their implication on the present-time radial location. {The average metallicities of the three clusters are all oversolar: [Fe/H]= $+0.12\pm0.04$ (NGC~6192), $+0.11\pm0.04$ (NGC 6404), $+0.37\pm0.03$ (NGC 6583). They are in qualitative agreement with their Galactocentric distances, being all internal OCs, and thus expected to be metal richer than the solar neighborhood. The abundance ratios of the other elements over iron [X/Fe] are consistent with solar values. The clusters we have analysed, together with other OC and Cepheid data, confirm a steep gradient in the inner disk, a signature of an evolutionary rate different than in the outer disk.Comment: 17 pages, 13 figures, A&A accepted for publicatio

Planetary Dynamics and Habitable Planet Formation In Binary Star Systems

Whether binaries can harbor potentially habitable planets depends on several factors including the physical properties and the orbital characteristics of the binary system. While the former determines the location of the habitable zone (HZ), the latter affects the dynamics of the material from which terrestrial planets are formed (i.e., planetesimals and planetary embryos), and drives the final architecture of the planets assembly. In order for a habitable planet to form in a binary star system, these two factors have to work in harmony. That is, the orbital dynamics of the two stars and their interactions with the planet-forming material have to allow terrestrial planet formation in the habitable zone, and ensure that the orbit of a potentially habitable planet will be stable for long times. We have organized this chapter with the same order in mind. We begin by presenting a general discussion on the motion of planets in binary stars and their stability. We then discuss the stability of terrestrial planets, and the formation of potentially habitable planets in a binary-planetary system.Comment: 56 pages, 29 figures, chapter to appear in the book: Planets in Binary Star Systems (Ed. N. Haghighipour, Springer publishing company

Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review

Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.This work was supported by the the Ministerio de Economía y Competitividad of Spain (AGL2015-64558-R, MINECO/FEDER, UE), by the FCT Project—UID/Multi/04423/2013, and by the Structured Program of R&D&I INNOVMAR—Innovation and Sustainability in the Management and Exploitation of Marine Resources (reference NORTE-01-0145-FEDER-000035, Research Line NOVELMAR), funded by the Northern Regional Operational Program (NORTE2020) through the European Regional Development Fund (ERDF). Alexandre Campos work is supported by a post-doctoral grant (SFRH/BPD/103683/2014) from Foundation for Science and Technology (FCT, Lisbon, Portugal)

The Latin American Consortium of Studies in Obesity (LASO)

Current, high-quality data are needed to evaluate the health impact of the epidemic of obesity in Latin America. The Latin American Consortium of Studies of Obesity (LASO) has been established, with the objectives of (i) Accurately estimating the prevalence of obesity and its distribution by sociodemographic characteristics; (ii) Identifying ethnic, socioeconomic and behavioural determinants of obesity; (iii) Estimating the association between various anthropometric indicators or obesity and major cardiovascular risk factors and (iv) Quantifying the validity of standard definitions of the various indexes of obesity in Latin American population. To achieve these objectives, LASO makes use of individual data from existing studies. To date, the LASO consortium includes data from 11 studies from eight countries (Argentina, Chile, Colombia, Costa Rica, Dominican Republic, Peru, Puerto Rico and Venezuela), including a total of 32 462 subjects. This article describes the overall organization of LASO, the individual studies involved and the overall strategy for data analysis. LASO will foster the development of collaborative obesity research among Latin American investigators. More important, results from LASO will be instrumental to inform health policies aiming to curtail the epidemic of obesity in the region