Clifford systems, Clifford structures, and their canonical differential forms

Un confronto tra differenti costruzioni in ℍ^2 ≅ ℝ^8 della 4-forma quaternionale Φ_{Sp(2)Sp(1)} e della calibrazione di Cayley Φ_{Spin(7)} mostra che per esse si può partire dalle “2-forme di Kähler”, che entrano sia in geometria quaternionale kähleriana che Spin(7). Tale confronto si collega con le nozioni di struttura di Clifford pari e di sistema di Clifford. Passando alla dimensione 16, simili costruzioni consentono di scrivere formule esplicite in ℝ^{16} per le 4-forme canoniche Φ_{Spin(8)} e Φ_{Spin(7)U(1)}, associate a sistemi di Clifford legati ai sottogruppi Spin(8) e Spin(7)U(1) di SO(16). Si caratterizzano i 4-piani calibrati delle 4-forme Φ_{Spin(8)} e Φ_{Spin(7)U(1)}, estendendo in due diversi modi la nozione di 4-piano di Cayley alla dimensione 16.A comparison among different constructions in ℍ^2 ≅ ℝ^8 of the quaternionic 4-form Φ_{Sp(2)Sp(1)} and of the Cayley calibration Φ_{Spin(7)} shows that one can start for them from the same collections of “Kähler 2-forms”, entering both in quaternion Kähler and in Spin(7) geometry. This comparison relates with the notions of even Clifford structure and of Clifford system. Going to dimension 16, similar constructions allow to write explicit formulas in ℝ^{16} for the canonical 4-forms Φ_{Spin(8)} and Φ_{Spin(7)U(1)}, associated with Clifford systems related with the subgroups Spin(8) and Spin(7)U(1) of SO(16). We characterize the calibrated 4-planes of the 4-forms Φ_{Spin(8)} and Φ_{Spin(7)U(1)}, extending in two different ways the notion of Cayley 4-plane to dimension 16

Minori e famiglie adottive: quali strumenti per una scuola inclusiva? Spunti di diritto interno e comparato

Il contributo parte dalla necessità di dare concreta attuazione all’ambizioso programma, prima di tutto costituzionale, di realizzare una “scuola aperta a tutti ed a misura di ciascuno”, assumendo come punto di vista quello dei minori e delle famiglie adottive. Cenni sono fatti anche alla condizione dei minori temporaneamente al di fuori della famiglia d’origine. L’ottica è quella della necessaria integrazione tra gli strumenti giuridici di natura pubblicistica e privatistica rispetto al raggiungimento di un ambiente scolastico inclusivo, che permetta l’armonizzazione tra i compiti di cura ed educazione dei genitori, o degli adulti altrimenti responsabili per il minore, e quelli delle istituzioni e professionisti coinvolti nell’erogazione di un servizio di istruzione personalizzata del minore, che ne rispetti e promuova la sua identità e personalità. L’analisi comparatistica, con particolare riferimento all’esperienza francese, permette di evidenziare alcuni possibili sviluppi futur

Minori e famiglie adottive: quali strumenti per una scuola inclusiva? Spunti di diritto interno e comparato

Il contributo parte dalla necessit\ue0 di dare concreta attuazione all\u2019ambizioso programma, prima di tutto costituzionale, di realizzare una \u201cscuola aperta a tutti ed a misura di ciascuno\u201d, assumendo come punto di vista quello dei minori e delle famiglie adottive. Cenni sono fatti anche alla condizione dei minori temporaneamente al di fuori della famiglia d\u2019origine. L\u2019ottica \ue8 quella della necessaria integrazione tra gli strumenti giuridici di natura pubblicistica e privatistica rispetto al raggiungimento di un ambiente scolastico inclusivo, che permetta l\u2019armonizzazione tra i compiti di cura ed educazione dei genitori, o degli adulti altrimenti responsabili per il minore, e quelli delle istituzioni e professionisti coinvolti nell\u2019erogazione di un servizio di istruzione personalizzata del minore, che ne rispetti e promuova la sua identit\ue0 e personalit\ue0. L\u2019analisi comparatistica, con particolare riferimento all\u2019esperienza francese, permette di evidenziare alcuni possibili sviluppi futur

Epigallocatechin-3-gallate inhibits doxorubicin-induced inflammation on human ovarian tissue

Chemotherapy protocol can destroy the reproductive potential of young cancer patients. Doxorubicin (DOX) is a potent anthracycline commonly used in the treatment of numerous malignancies. The purpose of the study was to evaluate the ovarian toxicity of DOX via inflammation and the possible protective effect of the green tea polyphenol epigallocatechin-3-gallate (EGCG). Ovarian tissue of three patients was cultured with 1 \ub5g/ml DOX and/or 10 \ub5g/ml EGCG for 24 and 48 h. Levels of inflammatory factors were determined by quantitative Real-Time PCR, western blot, zimography, and multiplex bead-based immunoassay. Morphological evaluation, damaged follicle count and TUNEL assay were also performed. DOX influenced inflammatory responses by inducing a significant increase in the expression of pro-inflammatory cytokines, such as tumor necrosis factor-\u3b1 (TNF-\u3b1) and cyclooxigenase-2 (COX-2), of inflammatory interleukins (IL), such as interleukin-6 (IL-6) and interleukin-8 (IL-8), and the inflammatory proteins mediators metalloproteinase-2 and metalloproteinase-9 (MMP2 and MMP9). IL-8 secretion in the culture supernatants and MMP9 activity also significantly raised after DOX treatment. Moreover, a histological evaluation of the ovarian tissue showed morphological damage to follicles and stroma after DOX exposure. EGCG significantly reduced DOX-induced inflammatory responses and improved the preservation of follicles. DOX-induced inflammation could be responsible for the ovarian function impairment of chemotherapy. EGCG could have a protective role in reducing DOX-mediated inflammatory responses in human ovarian tissue

Build-Up/Wash-Off Monitoring and Assessment for Sustainable Management of First Flush in an Urban Area

The characterization of stormwater runoff on urbanized surfaces by means of comparison between experimental data and simulations is a strict requirement for a sustainable management of urban sewer systems. A monitoring campaign was carried out within a residential area in Puglia (Southern Italy) in order to collect and evaluate quantity and quality data. A strong correlation was observed between COD (Chemical Oxygen Demand) and TSS (Total Suspended Solid) concentrations, whose values exceed water quality standards. TSS was used for calibration of Storm Water Management Model (SWMM) which was then validated with reference to the pollutograph’s shape and the peak-time. The first flush phenomenon occurrence was also investigated by looking at the distribution of pollutant mass vs. volume in stormwater discharges, using the so-called “M(V) curves”. Results show that on average the first 30% of that washed off carries 60% of TSS and provides important information for the design of efficient systems for first flush treatment

Pur-alpha functionally interacts with FUS carrying ALS-associated mutations

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to motor neuron loss. Fused in sarcoma (FUS) protein carrying ALS-associated mutations localizes to stress granules and causes their coalescence into larger aggregates. Here we show that Pur-alpha physically interacts with mutated FUS in an RNA-dependent manner. Pur-alpha colocalizes with FUS carrying mutations in stress granules of motoneuronal cells differentiated from induced pluripotent stem cells and that are derived from ALS patients. We observe that both Pur-alpha and mutated FUS upregulate phosphorylation of the translation initiation factor eukaryotic translation initiation factor 2 alpha and consistently inhibit global protein synthesis. In vivo expression of Pur-alpha in different Drosophila tissues significatively exacerbates the neurodegeneration caused by mutated FUS. Conversely, the downregulation of Pur-alpha in neurons expressing mutated FUS significatively improves fly climbing activity. All these findings suggest that Pur-alpha, through the control of mRNA translation, might be involved in the pathogenesis of ALS associated with the mutation of FUS, and that an alteration of protein synthesis may be directly implicated in the disease. Finally, in vivo RNAi-mediated ablation of Pur-alpha produced locomotion defects in Drosophila, indicating a pivotal role for this protein in the motoneuronal function

PO-485 Low abundance circulating proteins in giant cell tumours of bone

Introduction Circulating low-abundance proteins/fragments generating from tumour cells and tissues, represent the most important source of cancer biomarkers useful for early diagnosis and prognosis. Giant cell tumour of bone (GCT) is a benign neoplasm occurring in the long bone and in the axial skeleton of young adults. Approximately 5% of GCT develop pulmonary metastases. Although many biomarkers have been proposed, identification of circulating low abundance molecules may be useful to predict metastasis with a non invasive method. Material and methods The hydrogel nanoparticles technique followed by mass spectrometry was used to detect low molecular weight serum proteins or protein fragments in serum of 20 GCT patients with different clinical course and in 10 healthy sera used as control. The most representative low-abundant de novo or differentially abundant proteins were submitted to String database in order to define protein-protein interaction network. Cluster analysis was performed to identify prognostic groups of patients with similar abundance of proteins that significantly discriminate between the groups. Results and discussions For the 25 low-abundant de novo or differentially abundant proteins identified, we recognised that the top interconnected pathways included protein activation cascade, wound healing, blood coagulation, cell-substrate adhesion. Proteoma cluster analysis separated metastasis-free from metastatic GCT patients in two well-defined groups where serum levels of signalling transduction mediators and regulators of kinase activity presented a high discriminatory power. Increased expression of proteins STAT5B, GRB2 and OXSR1 was related to a higher probability of metastasis. Conclusion In conclusion, using a no invasive technique, we identified differentially abundant serum biomarkers, also providing prognostic information in patients with GCT of bone. Future studies are ongoing to establish the interplay between these biomarkers in order to fully understand the mechanism involved in tumour development and to focus on the planning of tailored therapies that should be more effective and less toxic

Проблема правової культури в історії філософсько-педагогічної думки

(uk) Стаття присвячена проблемі правової культури в історії філософсько-педагогічної думки

A semi-coherent generalization of the 5-vector method to search for continuous gravitational waves

The emission of continuous gravitational waves (CWs), with duration much longer than the typical data taking runs, is expected from several sources, notably spinning neutron stars, asymmetric with respect to their rotation axis and more exotic sources, like ultra-light scalar boson clouds formed around Kerr black holes and sub-solar mass primordial binary black holes. Unless the signal time evolution is well predicted and its relevant parameters accurately known, the search for CWs is typically based on semi-coherent methods, where the full data set is divided in shorter chunks of given duration, which are properly processed, and then incoherently combined. In this paper we present a semi-coherent method, in which the so-called \textit{5-vector} statistics is computed for the various data segments and then summed after the removal of the Earth Doppler modulation and signal intrinsic spin-down. The method can work with segment duration of several days, thanks to a double stage procedure in which an initial rough correction of the Doppler and spin-down is followed by a refined step in which the residual variations are removed. This method can be efficiently applied for directed searches, where the source position is known to a good level of accuracy, and in the candidate follow-up stage of wide-parameter space searches.Comment: 16 pages, 12 figure