Multiplet Structure below Threshold in Appearance-Potential Spectra—Lanthanum N4,5

We present the N4,5 appearance-potential spectrum of La. Structure exists at energies lower than the threshold energy for transitions terminating at the Fermi level. Several similarities between optical absorption spectra and our results are discussed. These results contradict the simple model usually used to interpret appearance-potential spectra and emphasize the need for a new theory

Investigating Habituation to Premonitory Urges in Behavior Therapy for Tic Disorders

Behavior therapy is effective for Persistent Tic Disorders (PTDs), but behavioral processes facilitating tic reduction are not well understood. One process, habituation, is thought to create tic reduction through decreases in premonitory urge severity. The current study tested whether premonitory urges decreased in youth with PTDs (N = 126) and adults with PTDs (N = 122) who participated in parallel randomized clinical trials comparing behavior therapy to psychoeducation and supportive therapy (PST). Trends in premonitory urges, tic severity, and treatment outcome were analyzed according to the predictions of a habituation model, whereby urge severity would be expected to decrease in those who responded to behavior therapy. Although adults who responded to behavior therapy showed a significant trend of declining premonitory urge severity across treatment, results failed to demonstrate that behavior therapy specifically caused changes in premonitory urge severity. In addition, reductions in premonitory urge severity in those who responded to behavior therapy were significant greater than those who did not respond to behavior therapy but no different than those who responded or did not respond to PST. Children with PTDs failed to show any significant changes in premonitory urges. Reductions in premonitory urge severity did not mediate the relationship between treatment and outcome in either adults or children. These results cast doubt on the notion that habituation is the therapeutic process underlying the effectiveness of behavior therapy, which has immediate implications for the psychoeducation and therapeutic rationale presented in clinical practice. Moreover, there may be important developmental changes in premonitory urges in PTDs, and alternative models of therapeutic change warrant investigation

Glutamate induces autophagy via the two-pore channels in neural cells

NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2. However, the activities of glutamate that are mediated by NAADP remain unclear. In this study, we evaluated the effect of glutamate on autophagy in astrocytes at physiological, non-toxic concentration. We found that glutamate induces autophagy at similar extent as NAADP. By contrast, the NAADP antagonist NED-19 or SiRNA-mediated inhibition of TPC1/2 decreases autophagy induced by glutamate, confirming a role for NAADP in this pathway. The involvement of TPC1/2 in glutamate-induced autophagy was also confirmed in SHSY5Y neuroblastoma cells. Finally, we show that glutamate leads to a NAADP-dependent activation of AMPK, which is required for autophagy induction, while mTOR activity is not affected by this treatment. Taken together, our results indicate that glutamate stimulates autophagy via NAADP/TPC/AMPK axis, providing new insights of how Ca2+ signalling glutamate-mediated can control the cell metabolism in the central nervous system

Human pharmacogenomic variation of antihypertensive drugs: from population genetics to personalized medicine.

AIM: To investigate the human pharmacogenetic variation related to antihypertensive drugs, providing a survey of functional interpopulation differences in hypertension pharmacogenes. MATERIALS & METHODS: The study was divided into two stages. In the first stage, we analyzed 1249 variants located in 57 hypertension pharmacogenes. This first-stage analysis confirmed that geographic origin strongly affects hypertension pharmacogenomic variation and that 31 pharmacogenes are geographically differentiated. In the second stage, we focused our attention on the ethnic-differentiated pharmacogenes, investigating 55,521 genetic variants. In silico analyses were performed to predict the effect of genetic variation. RESULTS: Our analyses indicated functional interpopulation differences, suggesting insight into the mechanisms of antihypertensive drug response. Moreover, our data suggested that rare variants mainly determine the functionality of genes related to antihypertensive drugs. CONCLUSION: Our study provided important knowledge about the genetics of the antihypertensive drug response, suggesting that next-generation sequencing technologies may develop reliable pharmacogenetic tests for antihypertensive drugs

New radio observations of anomalous microwave emission in the HII region RCW175

We have observed the HII region RCW175 with the 64m Parkes telescope at 8.4GHz and 13.5GHz in total intensity, and at 21.5GHz in both total intensity and polarization. High angular resolution, high sensitivity, and polarization capability enable us to perform a detailed study of the different constituents of the HII region. For the first time, we resolve three distinct regions at microwave frequencies, two of which are part of the same annular diffuse structure. Our observations enable us to confirm the presence of anomalous microwave emission (AME) from RCW175. Fitting the integrated flux density across the entire region with the currently available spinning dust models, using physically motivated assumptions, indicates the presence of at least two spinning dust components: a warm component with a relatively large hydrogen number density n_H=26.3/cm^3 and a cold component with a hydrogen number density of n_H=150/cm^3. The present study is an example highlighting the potential of using high angular-resolution microwave data to break model parameter degeneracies. Thanks to our spectral coverage and angular resolution, we have been able to derive one of the first AME maps, at 13.5GHz, showing clear evidence that the bulk of the AME arises in particular from one of the source components, with some additional contribution from the diffuse structure. A cross-correlation analysis with thermal dust emission has shown a high degree of correlation with one of the regions within RCW175. In the center of RCW175, we find an average polarized emission at 21.5GHz of 2.2\pm0.2(rand.)\pm0.3(sys.)% of the total emission, where we have included both systematic and statistical uncertainties at 68% CL. This polarized emission could be due to sub-dominant synchrotron emission from the region and is thus consistent with very faint or non-polarized emission associated with AME.Comment: Accepted for publication in the Astrophysical Journa

Detection and characterization of a 500 μm dust emissivity excess in the Galactic plane using Herschel/Hi-GAL observations

Context. Past and recent observations have revealed unexpected variations in the far-infrared – millimeter (FIR-mm) dust emissivity in the interstellar medium. In the Herschel spectral range, those are often referred to as a 500 μm emission excess. Several dust emission models have been developed to interpret astrophysical data in the FIR-mm domain. However, these are commonly unable to fully reconcile theoretical predictions with observations. In contrast, the recently revised two level system (TLS) model, based on the disordered internal structure of amorphous dust grains, seems to provide a promising way of interpreting existing data. Aims. The newly available Herschel infrared GALactic (Hi-GAL) data, which covers most of the inner Milky Way, offers a unique opportunity to investigate possible variations in the dust emission properties both with wavelength and environment. The goal of our analysis is to constrain the internal structure of the largest dust grains on Galactic scales, in the framework of the TLS model. Methods. By combining the IRIS (Improved Reprocessing of the IRAS Survey) 100 μm with the Hi-GAL 160, 250, 350, and 500 μm data, we model the dust emission spectra in each pixel of the Hi-GAL maps, using both the TLS model and, for comparison, a single modified black-body fit. The effect of temperature mixing along the line of sight is investigated to test the robustness of our results. Results. We find a slight decrease in the dust temperature with distance from the Galactic center, confirming previous results. We also report the detection of a significant 500 μm emissivity excess in the peripheral regions of the plane (35° < |l| < 70°) of about 13–15% of the emissivity, which can reach up to 20% in some HII regions. We present the spatial distributions of the best-fit values for the two main parameters of the TLS model, i.e. the charge correlation length, lc, used to characterize the disordered charge distribution (DCD) part of the model, and the amplitude A of the TLS processes with respect to the DCD effect. These distributions illustrate the variations in the dust properties with environment, in particular the plausible existence of an overall gradient with distance to the Galactic center. A comparison with previous findings in the solar neighborhood shows that the local value of the excess is less than expected from the Galactic gradient observed here

Experiment Investigating the Connection between Weak Values and Contextuality

Weak value measurements have recently given rise to a large interest for both the possibility of measurement amplification and the chance of further quantum mechanics foundations investigation. In particular, a question emerged about weak values being proof of the incompatibility between Quantum Mechanics and Non-Contextual Hidden Variables Theories (NCHVT). A test to provide a conclusive answer to this question was given in [M. Pusey, Phys. Rev. Lett. 113, 200401 (2014)], where a theorem was derived showing the NCHVT incompatibility with the observation of anomalous weak values under specific conditions. In this paper we realize this proposal, clearly pointing out the strict connection between weak values and the contextual nature of Quantum Mechanics.Comment: 5 pages, 4 figure

Detailed study of the microwave emission of the supernova remnant 3C 396

We have observed the supernova remnant 3C~396 in the microwave region using the Parkes 64-m telescope. Observations have been made at 8.4 GHz, 13.5 GHz, and 18.6 GHz and in polarisation at 21.5 GHz. We have used data from several other observatories, including previously unpublished observations performed by the Green Bank Telescope at 31.2 GHz, to investigate the nature of the microwave emission of 3C 396. Results show a spectral energy distribution dominated by a single component power law emission with $\alpha=(-0.364 \pm 0.017)$. Data do not favour the presence of anomalous microwave emission coming from the source. Polarised emission at 21.5 GHz is consistent with synchrotron-dominated emission. We present microwave maps and correlate them with infrared (IR) maps in order to characterise the interplay between thermal dust and microwave emission. IR vs. microwave TT plots reveal poor correlation between mid-infrared and microwave emission from the core of the source. On the other hand, a correlation is detected in the tail emission of the outer shell of 3C 396, which could be ascribed to Galactic contamination.Comment: published in MNRA