87 research outputs found

    Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics

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    "This is the accepted version of the following article: Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics (2017). J Pharm Pharmacol, 69: 554–566, which has been published in final form at http://dx.doi.org/10.1111/jphp.12612 . This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html]."Objective: This work evaluates the potential of using fresh milk to deliver theophylline to children.Methods: Theophylline–fresh milk systems were prepared using different solids ratios (0 : 1–1 : 0) and three fat contents in commercial milks (low, medium and high), which were spray-dried at different inlet air temperatures (Tinlet – 105, 130 and 150 °C). The process was evaluated for yield and the resulting powders for moisture content (MC), particle size and shape, density and wettability. Theophylline–milk potential interactions (differential scanning calorimetry (DSC) and FT-IR) and chemical (theophylline content) and microbiological stability of powders (shelf and in-use) were also evaluated.Key Findings: The production yield (13.6–76.0%), MC (0.0–10.3%) and contact angles in water (77.29–93.51°) were significantly (P < 0.05) affected by Tinlet, but no differences were found concerning the mean particle size (3.0–4.3 μm) of the different powders. The milk fat content significantly (P < 0.05) impacted on the density (1.244–1.552 g/cm3). Theophylline content remained stable after 6 months of storage, before extemporaneous reconstitution. After reconstitution in water, low-fat milk samples (stored at 4 °C) met the microbial pharmacopoeia criteria for up to 7 days. No theophylline–milk components interaction was observed.Conclusion: Spray-dried milk-composed powders may be used as vehicles for theophylline delivery in paediatrics following further characterization and in-vivo evaluation.info:eu-repo/semantics/publishedVersio

    Acrylamide formation and quality properties of chitosan based batter formulations

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    [EN] The potential of chitosan to mitigate acrylamide formation has been already demonstrated. The two main objectives of this study were: 1) to select the most adequate degree of deacetylation (DD) and molecular weight (Mw) of chitosan based on acrylamide mitigation criteria and 2) to evaluate the influence of including chitosan in batter formulations on some important technological parameters of raw batters (flow behavior and water retention capacity) and on some quality properties of fried batters (oil uptake, color and texture). Results in model systems showed that chitosans with higher deacetylation degree (86.5 and 92.8%) achieved a decrease of acrylamide between 44 and 81%, depending on reaction time, compared to the control (without chitosan). Furthermore, acid hydrolysis process of chitosan was found to negatively affect its inhibitory effect on acrylamide formation independently of the molecular weight. Raw chitosan based batter formulations presented higher consistency and water retention capacity than the control; chitosan addition to batters reduced the hardening of the fried samples during the post-frying cooling period. No significant differences in water loss were observed between batters with or without added chitosan; however, chitosan-batter formulations showed lower oil uptake during frying as compared to control samples.The authors thank the gs1:Universitat Politecnica de Valencia for the PhD scholarship given to Mariola Sansano Tomas.Sansano Tomás, M.; Castelló Gómez, ML.; Heredia Gutiérrez, AB.; Andrés Grau, AM. (2016). Acrylamide formation and quality properties of chitosan based batter formulations. Food Hydrocolloids. 66:1-7. doi:10.1016/j.foodhyd.2016.10.019S176

    Factors affecting browning and crystallisation of palm syrup and palm sugar cake

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    Doctor of Philosophy (Food Technology), 201

    Spatio-temporal State Space Model Estimation for Smart structures

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    EThOS - Electronic Theses Online ServiceGBUnited Kingdo

    INFLUENCE OF PACKAGING MATERIAL AND STORAGE TIME ON PHYSICAL, CHEMICAL AND MICROBIOLOGICAL PROPERTIES OF SET YOGURT: A COMPARATIVE STUDY BETWEEN MODIFIED BIODEGRADABLE POLY(LACTIC ACID) AND POLYPROPYLENE

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    The current paper investigates the influence of storage time and type of polymeric packaging material on the chemical, physical and microbiological properties of set yogurt. Firstly, poly(lactic acid) (PLA) was modified by using a core-shell rubber (CSR) and an acrylic processing aid (PA) to produce PLA with high toughness and good processability. Secondly, an appropriate PLA/PA/CSR composition was selected and fabricated to yogurt cup. The yogurt was stored in both modified PLA and polypropylene (PP) packages to observe some physical, chemical and biological changes. Finally, the biodegradation test was made on both packages and compared with that cellulose. Experimental results revealed that adding 5wt% CSR gave PLA/PA as tough as PP. Types of packaging material and storage time did not change the color of yogurt. The number of lactic acid bacteria grew significantly after they had been incubated for 6 days. The bacterial viability decreased dramatically due to the increased acidity and the decreased pH. A positive impact on the viability of bacterial growth was found when yogurt was stored in modified PLA package. This made yogurt had more health benefits than stored in PP package. The biodegradation test results indicated that the modified PLA degraded at a rapid rate. It achieved approximately 50% biodegradation within 40 days which was comparable to the time required to degrade the cellulose, whereas PP was non-biodegradable over the period studied. In summary, substitution conventional PP by a novel modified PLA seems to be a better way for both the health and the environment benefits

    Characterization of palm sap harvested in Songkhla province, Southern Thailand

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    International audienceThe purpose of this study was to characterise the quality of palm sap after harvested in Songkhla province, southern Thailand. Ten palm sap samples were analyzed. The results showed differed in physical and chemical quality among samples (P<0.05). The results showed range of L*, a* and b* values between 61.49 to 87.53, 1.46 to 3.52 and 12.41 to 19.31, respectively. The turbidity was ranged from 39.56% to 79.95%. The pH value was varied from 4.19 to 5.23, while total acidity was ranged from 0.27% to 0.93%. The total soluble solids ranged from 10.80 to 17.40OBrix. Total and reducing sugars were varied in a range of 10.36% to 16.94% and 0.88% to 3.56%, respectively. The sucrose, glucose and fructose contents were found vary in a range from 9.29% to 17.44%, 0.50% to 1.85% and 0.50% to 1.81%, respectively. Protein content varied from 0.31-0.39 mg/g. Ethanol was also found in all samples that indicating the fermentation. All results indicated a large variation quality of palm sap although they harvested in the same production area in Songkhla province. The different quality of palm sap was mainly due to the fermentation of sugars by the activity of microorganisms during palm sap collecting time

    Quality Profiles of Pasteurized Palm Sap (Borassus flabellifer Linn.) Collected from Different Regions in Thailand

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    Palm sap is obtained by tapping the inflorescence of the palmyra palm, and is usually used in terms of pasteurized palm sap. So far, this product has been produced by each producer using their own experience, and using conventional methods. Therefore, the purpose of this study was to characterize the quality of pasteurized palm sap collected from 3 provinces, including Bangkok, Phetchaburi, and Ayutthaya. Five pasteurized palm sap samples were randomly collected from each province, and analyzed for their physical, chemical and microbiological qualities. The results showed a range of L*, a* and b* values between 44.12 to 78.67, 0.40 to 2.61, and 10.47 to 19.33, respectively. The transmittance value ranged from 27.32 to 81.30 %. The pH value varied from 5.00 to 8.17, while total acidity ranged from 0.01 to 0.23 %. The total soluble solids ranged from 14.60 °Brix to 24.10 °Brix. Total and reducing sugars varied in a range of 14.23 to 24.10 %, and 0.25 to 8.47 %, respectively. The sucrose, glucose and fructose contents were found in a range from 13.67 to 19.05 %, 0.14 to 4.85 %, and 0.17 to 4.17 %, respectively. Phenolic content varied from 0.64 to 1.03 mg/g. The total viable count, and the yeast and mold count, of all samples were higher than the allowed maximum limit, as recommended by Thai Community Product Standards. The results indicated a large variation in quality of pasteurized palm sap among the 3 provinces (p < 0.05). doi:10.14456/WJST.2016.1

    Enhancing the quality attributes of salad dressing by incorporating Gac aril as a biologically active ingredient

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    Abstract Gac aril (GA) contains a very high level of lycopene, giving it exceptional antioxidant properties. Based on the superior properties of GA, the aim of this work was to fortify salad dressings with the lycopene from GA and monitor their stability during storage. The salad dressings were produced by incorporating different amounts of GA (0% to 20%, g/100 g) in the formulations. An increase in GA content caused a marked increase in the soluble fibre, lycopene and total phenolic contents while the fat content and the caloric value decreased. The firmness and viscosity also decreased with increasing GA content. The sensory evaluation revealed that the GA could be added to salad dressings up to a level of 20% and still be accepted by the consumer. It was verified the GA antioxidant effect in the salad dressing compared to that in the sample without GA, as evidenced by the peroxide value (POV), thiobarbituric acid-reactive substances (TBARS), p-anisidine value (p-AV) and total oxidation value (Totox V). The protective effects were approximately 1.75, 2.58, 5.14 and 7.58 times higher than those in the control sample for the samples containing 5%, 10%, 15% and 20% GA, respectively. It was concluded that GA could be used as an alternative source of lycopene, polyphenol compounds and dietary fibre, to enrich salad dressings. This work could be used as a guideline for industry to develop high value-added salad dressings
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