10,436 research outputs found
Dielectric constant of glasses: first observation of a two-dimensional behavior
The 1kHz real part of the dielectric constant of a structural glass
was measured at low temperature down to 14 mK. Reducing the sample
thickness to 10 nm suppresses the usual minimum of for measuring
fields MV/m. This contradicts the Two Level System (TLS) model but is
well accounted for by including TLS-TLS interactions where excitations
delocalize between TLS's through a -induced mechanism recently designed: for
small 's this interaction is reduced, which explains the two-dimensional
behavior of . Hence, interactions play a key role in standard thick
samples.Comment: latex finesse3.tex, 5 files, 4 figures, 4 pages [SPEC-S02/050],
submitted to Phys. Rev. Let
Equivariant representable K-theory
We interpret certain equivariant Kasparov groups as equivariant representable
K-theory groups. We compute these groups via a classifying space and as
K-theory groups of suitable sigma-C*-algebras. We also relate equivariant
vector bundles to these sigma-C*-algebras and provide sufficient conditions for
equivariant vector bundles to generate representable K-theory. Mostly we work
in the generality of locally compact groupoids with Haar system.Comment: Final version. Only minor corrections. 33 page
The Central Regions of M31 in the 3 - 5 micron Wavelength Region
Images obtained with NIRI on the Gemini North telescope are used to
investigate the photometric properties of the central regions of M31 in the 3 -
5 micron wavelength range. The light distribution in the central arcsecond
differs from what is seen in the near-infrared in the sense that the difference
in peak brigh tness between P1 and P2 is larger in M' than in K'; no obvious
signature of P3 is dete cted in M'. These results can be explained if there is
a source of emission that contributes ~ 20% of the peak M' light of P1 and has
an effective temperature of no more than a few hundred K that is located
between P1 and P2. Based on the red K-M' color of this source, it is suggested
that the emission originates in a circumstellar dust shell surrounding a single
bright AGB star. A similar bright source that is ~ 8 arcsec from the center of
the galaxy is also detected in M'. Finally, the (L', K-L') color-magnitude
diagram of unblended stars shows a domin ant AGB population with photometric
characteristics that are similar to those of the most luminous M giants in the
Galactic bulge.Comment: To appear in the Astronomical Journa
Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration
Intervertebral disc degeneration is characterized by an imbalance between catabolic and anabolic signaling, with an increase in catabolic cytokines particularly IL-1β, a key regulator of IVD degeneration. This study aimed to investigate intracellular signaling pathways activated by IL-1β, and GDF-5 in the degenerate IVD to identify potential new therapeutic targets. Human NP cells were cultured in alginate beads to regain in vivo phenotype prior to stimulation with IL-1β or GDF-5 for 30 min, a proteasome profiler array was initially utilized to screen activation status of 46 signaling proteins. Immunoflourescence was used to investigate activation of the NFκB pathway. Cell-based ELISAs were then deployed to confirm results for ERK1/2, p38 MAPK, c-jun, and IκB signaling. IHC was utilized to investigate native activation status within human IVD tissue between grades of degeneration. Finally, cells were stimulated with IL-1β in the absence or presence of p38 MAPK, c-jun, JNK, and NFκB inhibitors to investigate effects on MMP3, MMP13, IL-1β, IL-6, and IL-8 mRNA expression. This study demonstrated three key signaling pathways which were differentially activated by IL-1β but not GDF-5; namely p38 MAPK, c-jun, and NFκB. While ERK 1/2 was activated by both GDF-5 and IL-1. Immunohistochemistry demonstrated p38 MAPK, c-jun, and NFκB were activated during human IVD degeneration and inhibition of these pathways reduced or abrogated the catabolic effects of IL-1β, with inhibition of NFκB signaling demonstrating most widespread inhibition of IL-1β catabolic effect
Lunar drill footplate and casing
To prevent hole collapse during lunar drilling operations, a casing has been devised of a graphite reinforced polyimide composite which will be able to withstand the lunar environment. Additionally, this casing will be inserted into the ground in segments two meters long which will penetrate the regolith simultaneously with the auger. The vertical action of the mobile platform will provide a downward force to the casing string through a special adaptor, giving the casing the needed impetus to sink the anticipated depth of ten meters. Casing segments will be connected with a simple snap arrangement. Excess casing will be cut off by a cylindrical cutting tool which will also transport the excess casing away from the hole. A footplate will be incorporated to grasp the auger rod string during rod segment additions or removals. The footplate grasping mechanism will consist of a set of vice-like arms, one end of each bearing threaded to a common power screw. The power screw will be threaded such that one end's thread pitch opposes that of the other end. The weight of the auger and rod string will be transmitted through the arms to the power screw and absorbed by a set of three ball bearing assemblies. The power screw will be driven by a one-half horsepower brushless motor actuated by radio control. The footplate will rest on four short legs and be anchored with pins that are an integral part of each leg
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Monitoring the past and choosing the future: the prefrontal cortical influences on voluntary action.
Choosing between equivalent response options requires the resolution of ambiguity. One could facilitate such decisions by monitoring previous actions and implementing transient or arbitrary rules to differentiate response options. This would reduce the entropy of chosen actions. We examined voluntary action decisions during magnetoencephalography, identifying the spatiotemporal correlates of stimulus- and choice-entropy. Negative correlations between frontotemporal activity and entropy of past trials were observed after participants' responses, reflecting sequential monitoring of recent events. In contrast, choice entropy correlated negatively with prefrontal activity, before and after participants' response, consistent with transient activation of latent response-sets ahead of a decision and updating the monitor of recent decisions after responding. Individual differences in current choices were related to the strength of the prefrontal signals that reflect monitoring of the statistical regularities in previous events. Together, these results explain individual expressions of voluntary action, through differential engagement of prefrontal areas to guide sequential decisions
Light storage protocols in Tm:YAG
We present two quantum memory protocols for solids: A stopped light approach
based on spectral hole burning and the storage in an atomic frequency comb.
These procedures are well adapted to the rare-earth ion doped crystals. We
carefully clarify the critical steps of both. On one side, we show that the
slowing-down due to hole-burning is sufficient to produce a complete mapping of
field into the atomic system. On the other side, we explain the storage and
retrieval mechanism of the Atomic Frequency Comb protocol. This two important
stages are implemented experimentally in Tm- doped
yttrium-aluminum-garnet crystal
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