Even a little goes a long way for health? Physical activity, obesity, health-related quality of life and depression

Overweight, obesity and physical inactivity (PI) are of major public health concern globally and associated with multiple adverse health outcomes. Overweight and obese populations experience diminished health-related quality of life (HRQOL) and greater depression symptoms when compared to their normal weight counterparts. Emerging evidence suggests ‘small changes’ in physical activity can produce positive health benefits. The aim of this study was to investigate the effects of a little physical activity across body mass index (BMI) status on HRQOL and depression outcomes. Secondary data analysis was conducted using the ‘US 2015 Behavioral Risk Factor Surveillance System’ survey. A total of 4,442 participants with complete and valid responses were included in the analysis. A two-way MANOVA was conducted with BMI (normal weight, overweight, obese) and physical activity (PI, insufficiently active [IA] < 150 min/week) as independent variables and HRQOL-4 and Patient Health Questionnaire-8 (PHQ-8; depression symptoms) as dependent variables. Statistically significant physical activity main effect revealed the IA groups reported improvements in general health (‘very good’ versus ‘good’), roughly 6.5 days physical health and 3 days mental health, and PHQ-8 (‘none-to-minimal depression’ versus ‘mild depression’) compared to PI groups (p < .001). The overweight groups had larger improvements across dependent variables (except general health) compared to normal weight and obese groups. These findings add support to the growing small changes research, which suggests engaging in a little physical activity can improve health outcomes in overweight and obese populations

Mentoring and coaching in promoting publications in the Department of Physiotherapy at a local university in South Africa

A growing shift towards research and evidence based practice in academia is associated with requirements to disseminate research results in the form of publication in peer reviewed journals. Mentoring has been identified as an important component of developing young authors, as it increases confidence and competence, and facilitates professional development. This led to the formation of a support group to stimulate peer-review publication in the physiotherapy department at the University of the Western Cape. The Kirkpatrick Framework of Evaluation was used to evaluate the success of the mentoring process which made use of a participatory action research methodology. The writing group consisted of nine academic members of staff and took place over ten weeks. The programme included writing, giving feedback, discussion and peer review on a weekly basis. Focus group discussions were taped and transcribed in order to evaluate the mentoring process by identifying relationships within the data and categorising key concepts, which were shaped into a thematic framework. The findings indicated that participants experienced a variety of emotions throughout the programme, with an overall feeling of personal growth by the end. In addition, participants also reported improved writing, reviewing and communication skills. Six months following the programme, six participants had submitted at least one article to a peer reviewed journal. It is clear from this study that some academics still find the task of writing and reviewing articles daunting, and that guidance and support in the form of a writing programme can be useful.Embargo notic

UBVRIz light curves of 51 type II supernovae

We present a compilation of UBVRIz light curves of 51 type II supernovae discovered during the course of four different surveys during 1986–2003: the Cerro Tololo Supernova Survey, the Calán/Tololo Supernova Program (C&T), the Supernova Optical and Infrared Survey (SOIRS), and the Carnegie Type II Supernova Survey (CATS). The photometry is based on template-subtracted images to eliminate any potential host galaxy light contamination, and calibrated from foreground stars. This work presents these photometric data, studies the color evolution using different bands, and explores the relation between the magnitude at maximum brightness and the brightness decline parameter (s) from maximum light through the end of the recombination phase. This parameter is found to be shallower for redder bands and appears to have the best correlation in the B band. In addition, it also correlates with the plateau duration, being shorter (longer) for larger (smaller) s values

Mental health and quality of life outcomes of gender-affirming surgery: A systematic literature review

Introduction: Transgender individuals experience disproportionately higher rates of mental health concerns and lower quality of life (QoL) than the general population. Gender-affirming healthcare can reduce negative mental health outcomes and improve QoL. This review explores the mental health and QoL outcomes to accessing gender-affirming surgery for transgender individuals. Method: Following the PRISMA guidelines, searches were conducted using five databases for peer-reviewed articles, in English, with full-text available online published between January 2000 and August 2021. Result: 53 studies were included. Findings indicate reduced rates of suicide attempts, anxiety, depression, and symptoms of gender dysphoria along with higher levels of life satisfaction, happiness and QoL after gender-affirming surgery. Some studies reported that initial QoL improvements post gender-affirming surgery were not always enduring. Conclusion: This review supports the need for more sustainable and accessible gender-affirming surgery as a means for improving the mental health and overall QoL among transgender individuals and indicates the need for further research with greater methodological rigor focusing on correlates of positive gender-affirming surgical outcomes. Without social, legal, and public policy responses to transgender discrimination, marginalization and exclusion, the beneficial outcomes of improved gender-affirming surgery will remain unclear

UBVRIz Light Curves of 51 Type II Supernovae

We present a compilation of UBV RIz light curves of 51 type II supernovae discovered during the course of four different surveys during 1986 to 2003: the Cerro Tololo Supernova Survey, the Calan/Tololo Supernova Program (C&T), the Supernova Optical and Infrared Survey (SOIRS), and the Carnegie Type II Supernova Survey (CATS). The photometry is based on template-subtracted images to eliminate any potential host galaxy light contamination, and calibrated from foreground stars. This work presents these photometric data, studies the color evolution using different bands, and explores the relation between the magnitude at maximum brightness and the brightness decline parameter (s) from maximum light through the end of the recombination phase. This parameter is found to be shallower for redder bands and appears to have the best correlation in the B band. In addition, it also correlates with the plateau duration, being thus shorter (longer) for larger (smaller) s values.Comment: 110 pages, 9 Figures, 6 Tables, accepted in A

Nonlinear modeling of venous leg ulcer healing rates

<p>Abstract</p> <p>Background</p> <p>The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics.</p> <p>Methods</p> <p>We studied 3,588 serial wound tracings of 338 venous leg ulcers (VLUs) that had been followed during a controlled, prospective, randomized trial of two topical wound treatments.</p> <p>Results</p> <p>A majority (72%) of VLUs exhibited surface area reduction via an exponential decay model, particularly during the early stages of healing. These results were consistent with the mechanics of wound contraction and epithelial cell proliferation, supported by the higher frequency at which exponential surface area reduction associated with full wound closure (35% of wounds that fit the exponential model healed vs. 21% of wounds that did not fit the exponential model completely healed during the study period, p = 0.018). Goodness-of-fit statistics suggested that much of the individual variation in healing could be described as nonlinear variation from the exponential model.</p> <p>Conclusion</p> <p>We believe that parameter estimates from a mathematical model may provide a more accurate quantification of wound healing rates, and that similar models may someday reach routine use in comparing the efficacy of various treatments in routine practice and in product registration trials.</p

Navigating intimate trans citizenship while incarcerated in Australia and the United States

Trans women incarcerated throughout the world have been described as 'vulnerable populations' due to significant victimization, mistreatment, lack of gender-affirming care, and human rights violations, which confers greater risk of trauma, self-harm, and suicide compared with the general incarcerated population. Most incarceration settings around the world are segregated by the person’s sex characteristics (i.e., male or female) and governed by strong cis and gender normative paradigms. This analysis seeks to better understand and appreciate how the 'instructions' and the 'authorities' that regulate trans women’s corporeal representation, housing options and sense of self-determination implicate and affect their agency and actions in handling intimacies related to their personal life. Drawing upon lived incarcerated experiences of 24 trans women in Australia and the United States, and employing Ken Plummer’s notion of intimate citizenship, this analysis explores how trans women navigate choices and ways 'to do' gender, identities, bodies, emotions, desires and relationships while incarcerated in men’s prisons and governed by cis and gender normative paradigms. This critical analysis contributes to understanding how incarcerated trans women through grit, resilience, and ingenuity still navigate ways to embody, express and enact their intimate citizenship in innovative and unique ways

Repressor CopG prevents access of RNA polymerase to promoter and actively dissociates open complexes

Replication of the promiscuous plasmid pMV158 requires expression of the initiator repB gene, which is controlled by the repressor CopG. Genes repB and copG are co-transcribed from promoter Pcr. We have studied the interactions between RNA polymerase, CopG and the promoter to elucidate the mechanism of repression by CopG. Complexes formed at 0°C and at 37°C between RNA polymerase and Pcr differed from each other in stability and in the extent of the DNA contacted. The 37°C complex was very stable (half-life of about 3 h), and shared features with typical open complexes generated at a variety of promoters. CopG protein repressed transcription from Pcr at two different stages in the process leading to the initiation complex. First, CopG hindered binding of RNA polymerase to the promoter. Second, CopG was able to displace RNA polymerase once the enzyme has formed a stable complex with Pcr. A model for the CopG-mediated disassembly of the stable RNA polymerase–Pcr promoter complex is presented

Neural Crest Cell Survival Is Dependent on Rho Kinase and Is Required for Development of the Mid Face in Mouse Embryos

Neural crest cells (NCC) give rise to much of the tissue that forms the vertebrate head and face, including cartilage and bone, cranial ganglia and teeth. In this study we show that conditional expression of a dominant-negative (DN) form of Rho kinase (Rock) in mouse NCC results in severe hypoplasia of the frontonasal processes and first pharyngeal arch, ultimately resulting in reduction of the maxilla and nasal bones and severe craniofacial clefting affecting the nose, palate and lip. These defects resemble frontonasal dysplasia in humans. Disruption of the actin cytoskeleton, which leads to abnormalities in cell-matrix attachment, is seen in the RockDN;Wnt1-cre mutant embryos. This leads to elevated cell death, resulting in NCC deficiency and hypoplastic NCC-derived craniofacial structures. Rock is thus essential for survival of NCC that form the craniofacial region. We propose that reduced NCC numbers in the frontonasal processes and first pharyngeal arch, resulting from exacerbated cell death, may be the common mechanism underlying frontonasal dysplasia

Exploring human-nature relationships in academic literature on the nitrogen cycle

The nitrogen (N) cycle is a familiar concept. As is the much simplified, often diagrammatic, representation commonly used to illustrate the scale, importance and interconnectedness of this global cycle that links air, water, rocks and living beings. However, in this representation, humans are often presented as a seemingly minor entity or not explicitly shown at all. This can obscure the idea that humanity is both a direct beneficiary of the nitrogen cycle (through food and resources) and an increasingly significant influence on its function. This study sought to understand how diverse Human-Nature relationships (HNR) are expressed in recent academic literature on the nitrogen cycle. A sample of peer-reviewed literature, containing explicit and inferred examples of HNR and the nitrogen cycle, was analysed using two approaches: 1) network analysis, identifying and illustrating all quantifiable links made between components of the nitrogen cycle, and 2) content analysis to understand how different kinds of terminology were being used to describe relationships between components in the cycle. The network analysis revealed diverse links between ‘human’ and ‘non-human nature’. The content analysis found some explicit use of relational terms, most commonly ‘depend*’. Both approaches highlighted strongly reciprocal links within the ‘human’ realm and the explicit centrality in which this is held across the corpus. We demonstrate the utility of combining quantitative and qualitative analysis to understand nuanced relationships in the nitrogen cycle and explore the utility this has to increase the acknowledgement and appreciation of HNR in science communication and science-policy interface work