Women Returning to Employment, Education and Training in Ireland - An Analysis of Transitions

Recent improvements in the Irish labour market have led to a substantial increase in the labour force participation rate of women in Ireland. Part of this increase has been fuelled by women moving from the home into paid employment. Much of the existing research on labour market activity among Irish women has focused on cross-sectional analyses of the stock of labour market participants. In this paper we aim to address some of the gaps in the literature by investigating the transition from home to work, and from home to education, training and employment schemes among women in Ireland during the period 1994 to 1999. We adopt a dynamic approach by drawing on the nationally representative longitudinal data in the Living in Ireland Survey. This allows us to provide, for the first time, a representative profile of returners, and to formally model the transition process in terms of supply and demand factors. The analysis also investigates the factors associated with the return to part-versus full-time work. Our analysis reveals that about one-quarter of those engaged full-time in home duties in 1994 had made a transition to paid work within the six-year period 1994-1999. The study identifies a number of key factors that influence the transition from home to work or education, training and employment schemes, including, on the supply side, age, education, previous work experience, time out of the labour force, and the presence of young children in the household, and on the demand side, macro-economic conditions and urban versus rural residence.

EUROPEAN MIGRATION NETWORK. IMMIGRATION OF INTERNATIONAL STUDENTS TO THE EU: IRELAND

This report is the Irish contribution to the EMN study on the ‘Immigration of International (non-EEA) Students to the EU’. This EMN study topic is particularly timely in the Irish case, as it follows a period of significant policy activity in this domain throughout 2010 and 2011. In September 2010, the Irish Government launched its first international education strategy, entitled Investing in Global Relationships: Ireland’s International Education Strategy 2010-15. The publication of the strategy was the culmination of efforts to facilitate a more joined-up approach to the provision of international education, with efforts co-ordinated by a High-Level Group on International Education. The Irish contribution to the EMN study is set within this overarching context

Literacy, Numeracy and Activation among the Unemployed. RESEARCH SERIES NUMBER 25 June 2012

It is well established in research that people with weak literacy and numeracy skills are more likely to be unemployed. Therefore, it should follow that this issue is an important consideration in labour market policy and more particularly activation policy. However, the National Adult Literacy Agency (NALA) is of the view that this has not always been the case and is concerned that unemployed adults with literacy and numeracy needs, and those with low educational attainment, are not being adequately prioritised for labour market activation. This research puts forward an argument for this to be changed

The Changing Workplace: A Survey of Employees’ Views and Experiences. The National Workplace Surveys 2009, Vol.2 Employees

Abstract included in text

Impact Evaluation of the European Employment Strategy in Ireland. ESRI General Papers

Recent years have seen dramatic growth in employment following unprecedented economic growth and development during the 1990s. Total employment in Ireland grew by a remarkable 534,000, or by 46%, in the eight years from 1993 to 2001, and over 220,000 of this was achieved between 1998 and 2001. In very recent years, the rate of growth in employment fallen somewhat, from a peak of almost 7% in 1997-1998 to about 4% in 2000- 2001. The rapid growth in the economy and in employment after 1993 led to a steady decline in unemployment from 220,000 in 1993 to 127,000 in the 2nd quarter of 1998 and to 65,000 in the 2nd quarter of 2001. The unemployment rate thus fell from 15.7% of the labour force in 1993 to 7.8% in the 2nd quarter of 1998 and to 3.7% in the 2nd quarter of 2001. With the deterioration in the international economy, and the slowdown in the Irish growth rate in 2001, unemployment increased to just under 80,000, or 4.3% of the labour force, in the 3rd quarter of 2001

Impact of the Great Recession on Unemployed Youth and NEET Individuals. ESRI Research Bulletin 2015/1/3

The impact that the Great Recession had on Ireland’s labour market is well documented, with the country’s unemployment rate increasing from 4.6 per cent in 2006 to 15 per cent in 2012. Young people were particularly hard hit by the downturn: their unemployment rate increased from 9.9 per cent to 33 per cent over the same time period. With this, the proportion of unemployed youths with no formal education increased over the recessionary period, as did the percentage that were long-term unemployed and those not in employment, education or training (NEET). While policymakers are aware of the unemployment rate of young people, little is known about this group’s profile or their labour market transitions, specifically into employment, pre and post the Great Recession. The same is true for NEET individuals. Given the importance of this information in the design of effective activation measures to assist unemployed youths and NEET individuals, ESRI researchers were involved in a number of studies examining unemployed and NEET youths: some of this work was undertaken in collaboration with the OECD. The results from this research are summarised in this Research Bulletin

Epigenetic and transcriptome profiling identifies a population of visceral adipose-derived progenitor cells with potential to differentiate into an endocrine pancreatic lineage

Type 1 diabetes (T1D) is characterized by the loss of insulin-producing β-cells in the pancreas. T1D can be treated using cadaveric islet transplantation, but this therapy is severely limited by a lack of pancreas donors. To develop an alternative cell source for transplantation therapy, we carried out the epigenetic characterization in nine different adult mouse tissues and identified visceral adipose-derived progenitors as a candidate cell population. Chromatin conformation, assessed using chromatin immunoprecipitation (ChIP) sequencing and validated by ChIP-polymerase chain reaction (PCR) at key endocrine pancreatic gene promoters, revealed similarities between visceral fat and endocrine pancreas. Multiple techniques involving quantitative PCR, in-situ PCR, confocal microscopy, and flow cytometry confirmed the presence of measurable (2–1000-fold over detectable limits) pancreatic gene transcripts and mesenchymal progenitor cell markers (CD73, CD90 and CD105; >98%) in visceral adipose tissue-derived mesenchymal cells (AMCs). The differentiation potential of AMCs was explored in transgenic reporter mice expressing green fluorescent protein (GFP) under the regulation of the Pdx1 (pancreatic and duodenal homeobox-1) gene promoter. GFP expression was measured as an index of Pdx1 promoter activity to optimize culture conditions for endocrine pancreatic differentiation. Differentiated AMCs demonstrated their capacity to induce pancreatic endocrine genes as evidenced by increased GFP expression and validated using TaqMan real-time PCR (at least 2–200-fold relative to undifferentiated AMCs). Human AMCs differentiated using optimized protocols continued to produce insulin following transplantation in NOD/SCID mice. Our studies provide a systematic analysis of potential islet progenitor populations using genome-wide profiling studies and characterize visceral adipose-derived cells for replacement therapy in diabetes

Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells

Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing vasoconstriction when the endothelium is disrupted. Among the three α1-AR subtypes (α1A, α1B, and α1D), the α1D subtype predominates in human epicardial coronary arteries and is functional in human coronary smooth muscle cells (SMCs). However, the presence or function of α1-ARs on human coronary endothelial cells (ECs) is unknown. Here we tested the hypothesis that human epicardial coronary ECs express functional α1-ARs. Cultured human epicardial coronary artery ECs were studied using quantitative real-time reverse transcription polymerase chain reaction, radioligand binding, immunoblot, and 3H-thymidine incorporation. The α1B-subtype messenger ribonucleic acid (mRNA) was predominant in cultured human epicardial coronary ECs (90–95% of total α1-AR mRNA), and total α1-AR binding density in ECs was twice that in coronary SMCs. Functionally, NE and EPI through the α1B subtype activated extracellular signal-regulated kinase (ERK) in ECs, stimulated phosphorylation of EC endothelial nitric oxide synthase (eNOS), and increased deoxyribonucleic acid (DNA) synthesis. These results are the first to demonstrate α1-ARs on human coronary ECs and indicate that the α1B subtype is predominant. Our findings provide another potential mechanism for adverse cardiac effects of drug antagonists that nonselectively inhibit all three α1-AR subtypes

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

Type I interferon (IFN) α/β is critical for host defense. During endotoxicosis or highly lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-α/β receptor (IFNAR) display decreased systemic inflammation and improved outcome. However, human sepsis mortality often occurs during a prolonged period of immunosuppression and not from exaggerated inflammation. We used a low lethality cecal ligation and puncture (CLP) model of sepsis to determine the role of type I IFNs in host defense during sepsis. Despite increased endotoxin resistance, IFNAR−/− and chimeric mice lacking IFNAR in hematopoietic cells display increased mortality to CLP. This was not associated with an altered early systemic inflammatory response, except for decreased CXCL10 production. IFNAR−/− mice display persistently elevated peritoneal bacterial counts compared with wild-type mice, reduced peritoneal neutrophil recruitment, and recruitment of neutrophils with poor phagocytic function despite normal to enhanced adaptive immune function during sepsis. Importantly, CXCL10 treatment of IFNAR−/− mice improves survival and decreases peritoneal bacterial loads, and CXCL10 increases mouse and human neutrophil phagocytosis. Using a low lethality sepsis model, we identify a critical role of type I IFN–dependent CXCL10 in host defense during polymicrobial sepsis by increasing neutrophil recruitment and function