A modified Oster-Murray-Harris mechanical model of morphogenesis

There are two main modeling paradigms for biological pattern formation in developmental biology: chemical prepattern models and cell aggregation models. This paper focuses on an example of a cell aggregation model, the mechanical model developed by Oster, Murray, and Harris [Development, 78 (1983), pp. 83--125]. We revisit the Oster--Murray--Harris model and find that, due to the infinitesimal displacement assumption made in the original version of this model, there is a restriction on the types of boundary conditions that can be prescribed. We derive a modified form of the model which relaxes the infinitesimal displacement assumption. We analyze the dynamics of this model using linear and multiscale nonlinear analysis and show that it has the same linear behavior as the original Oster--Murray--Harris model. Nonlinear analysis, however, predicts that the modified model will allow for a wider range of parameters where the solution evolves to a bounded steady state. The results from both analyses are verified through numerical simulations of the full nonlinear model in one and two dimensions. The increased range of boundary conditions that are well-posed, as well as a wider range of parameters that yield bounded steady states, renders the modified model more applicable to, and more robust for, comparisons with experiments

NASA/JSC ISSLive!

Just 150 miles above us, the International Space Station (ISS) is orbiting. Each day, the astronauts on board perform a variety of activities from exercise, science experiments, and maintenance. Yet, many on the ground do not know about these daily activities. National Aeronautics Space Agency/ Johnson Space Center (NASA/JSC) innovation creation ISSLive! - an education project - is working to bridge this knowledge gap with traditional education channels such as schools, but also non-traditional channels with the non-technical everyday public. ISSLive! provides a website that seamlessly integrates planning and telemetry data, video feeds, 3D models, and iOS and android applications. Through the site, users are able to view astronauts daily schedules, in plain English alongside the original data. As an example, when an astronaut is working with a science experiment, a user will be able to read about the activity and for more detailed activities follow provided links to view more information all integrated into the same site. Live telemetry data from a predefined set can also be provided alongside the activities. For users to learn more, 3D models of the external and internal parts of the ISS are available, allowing users to explore the station and even select sensors, such as temperature, and view a real-time chart of the data. Even ground operations are modeled with a 3D mission control center, providing users information on the various flight control disciplines and showing live data that they would be monitoring. Some unique activities are also highlighted and have dedicated spaces to explore in more detail. Education is the focus of ISSLive!, even from the beginning when university students participated in the development process as part of their master s projects. Focus groups at a Houston school showed interest in the project and excitement towards including ISSLive! in their classroom. Through this inclusion, students' knowledge can be assessed with projects, oral presentations, and other assignments. For the public citizens outside of the traditional education system, ISSLive! provides a single, interactive, and engaging experience to learn about the ISS and its role in space exploration, international collaboration, and science. While traditional students are using ISSLive! in the classroom, their parents, grandparents, and friends are using it at home. ISSLive! truly brings the daily operations of the ISS into the daily lives of the public from every generation

Mouse frontal cortex mediates additive multisensory decisions

The brain can combine auditory and visual information to localize objects. However, the cortical substrates underlying audiovisual integration remain uncertain. Here, we show that mouse frontal cortex combines auditory and visual evidence; that this combination is additive, mirroring behavior; and that it evolves with learning. We trained mice in an audiovisual localization task. Inactivating frontal cortex impaired responses to either sensory modality, while inactivating visual or parietal cortex affected only visual stimuli. Recordings from >14,000 neurons indicated that after task learning, activity in the anterior part of frontal area MOs (secondary motor cortex) additively encodes visual and auditory signals, consistent with the mice's behavioral strategy. An accumulator model applied to these sensory representations reproduced the observed choices and reaction times. These results suggest that frontal cortex adapts through learning to combine evidence across sensory cortices, providing a signal that is transformed into a binary decision by a downstream accumulator

Ultraviolet and Optical Observations of OB Associations and Field Stars in the Southwest Region of the Large Magellanic Cloud

Using photometry from the Ultraviolet Imaging Telescope (UIT) and photometry and spectroscopy from three ground-based optical datasets we have analyzed the stellar content of OB associations and field areas in and around the regions N 79, N 81, N 83, and N 94 in the LMC. We compare data for the OB association Lucke-Hodge 2 (LH 2) to determine how strongly the initial mass function (IMF) may depend on different photometric reductions and calibrations. We also correct for the background contribution of field stars, showing the importance of correcting for field star contamination in determinations of the IMF of star formation regions. It is possible that even in the case of an universal IMF, the variability of the density of background stars could be the dominant factor creating the differences between calculated IMFs for OB associations. We have also combined the UIT data with the Magellanic Cloud Photometric Survey to study the distribution of the candidate O-type stars in the field. We find a significant fraction, roughly half, of the candidate O-type stars are found in field regions, far from any obvious OB associations. These stars are greater than 2 arcmin (30 pc) from the boundaries of existing OB associations in the region, which is a distance greater than most O-type stars with typical dispersion velocities will travel in their lifetimes. The origin of these massive field stars (either as runaways, members of low-density star-forming regions, or examples of isolated massive star formation) will have to be determined by further observations and analysis.Comment: 16 pages, 10 figures (19 PostScript files), tabular data + header file for Table 1 (2 ASCII files). File format is LaTeX/AASTeX v.502 using the emulateapj5 preprint style (included). Also available at http://www.boulder.swri.edu/~joel/papers.html . To appear in the February 2001 issue of the Astronomical Journa

Incidence of Ischemic Colitis and Serious Complications of Constipation Among Patients Using Alosetron: Systematic Review of Clinical Trials and Post-Marketing Surveillance Data

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75196/1/j.1572-0241.2006.00459.x.pd

A case of mistaken identity – reappraisal of the species of canid and felid hookworms (Ancylostoma) present in Australia and India

This study serves to clarify the current status of canid and felid Ancylostoma species present in Australia. The morphological identification of A. ceylanicum from cats for the first time in Townsville, Australia, appears to be in error, together with the genetic markers provided for the species. Morphological and genetic data presented herein provide strong evidence that the hookworms from cats in Towsville are not A. ceylanicum as previously identified (i.e. the first report of this species in Australia), but are A. braziliense. Therefore the subsequent genetic markers established for A. ceylanicum in subsequent molecular studies based on these Townsville specimens should also be attributed to A. braziliense. Based on this information, a study of canine hookworm species present in northern India is also in error and it is apparent that the hookworms found in this region are those of A. ceylanicum. The distribution of A. braziliense and A. ceylanicum in the Americas and Asia Pacific region is discussed together with the importance of combining parasite morphology with genetic data for parasite diagnosis in epidemiological studies

Investigating the prevalent security techniques in wireless sensor network protocols

The radio architectures of and protocols used by wireless sensor networks (WSNs) are, typically, very similar and are based on IEEE 802.15.4. By concentrating on this standard and the associated employed security techniques, the possibility of designing a transferable safety and privacy enhancement across protocols and services, becomes a reality. WSN applications have expanded significantly over the past decade or so and adopt commercial off-the-shelf (COTS) devices and publicly available standards, which inherently creates intruder incentives and security challenges. Securing WSNs is a critical requirement due to the challenging burden of protecting the transmitted sensitive information across various applications, while operating under unique security vulnerabilities and a fluctuating radio frequency (RF) spectrum and physical environment. Couple this aspect with establishing a level of trust among network nodes, while providing resilience to interference, it becomes clear that maintaining security is challenging. This paper identifies unique vulnerabilities in WSNs, which have a direct impact on privacy and safety. The prevalent security techniques used in the common PHY and MAC layers of various WSN protocols are discussed in terms of providing the essential security requirements. An experimental visualization of the coexistence issues in the industrial, scientific and medical (ISM) RF band, which is integral for IoT operations, is provided as an introduction to a new perspective on attacking WSNs. Fundamental attack styles and spectrum sharing/coexistence based intrusions are presented. Typical methods, which use COTS devices and open source software to exploit WSN security holes, are also discussed

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

MDAN-21, , a bivalent opioid ligand containing a mu-opioid receptor agonist (derived from oxymorphone) linked to the delta-opioid receptor antagonist (related to naltrindole) by a spacer of 21 atoms, was reported to have potent analgesic properties in mice. Tolerance, physical dependence, and conditioned place preference were not evident in that species. The finding that bivalent ligands in this series, with spacers 19 atoms or greater, were devoid of tolerance and dependence led to the proposal that MDAN-21 targets heteromeric mu-delta-opioid receptors. The present study focused on its effects in nonhuman primates (Macaca mulatta), a species with a physiology and behavioral repertoire not unlike humans. With regard to opioids, this species usually better predicts clinical outcomes. MDAN-21 substituted for morphine in morphine-dependent monkeys in the remarkably low dose range 0.006–0.032 mg/kg, subcutaneously. Although MDAN-21 failed to produce reliable thermal analgesia in the dose range 0.0032–0.032 mg/kg, intramuscularly, it was active in the same dose range and by the same route of administration, in the capsaicin-induced thermal allodynia assay. The results suggest that MDAN-21 may be useful in the treatment of opioid dependence and allodynia. The data provide additional evidence that opioid withdrawal is associated with sensitized pain