The Logbook, A Publication of the Wayne E. Meyer Institute of Systems Engineering / May 2004

www.nps.navy.mil/meyerinstitute Email:[email protected] Phone:(831) 656-7847 Fax:(831) 656-2336 Naval Postgraduate School, 777 Dyer Rd., Mail Code 97, Monterey, CAArticles include: Turnover Time, Joint Executive Systems Engineering and Management Program (SEM-PD21), and Integrated Campus Projects and the Meyer Institute.Naval Postgraduate School, Monterey, C

Moneyball\u27s Impact on Business and Sports

The article presents a transcript of the \u27Moneyball\u27s\u27 Impact on Business and Sports panel discussion which was held as part of the annual Villanova Sports and Entertainment Law Journal Symposium in Villanova, Pennsylvania in February 2012. The panel, which featured former Pennsylvania Governor Edward G. Rendell and Oakland Athletics baseball team General Manager Billy Beane, discussed the impact of Michael Lewis\u27 book Moneyball: The Art of Winning an Unfair Game on the game of baseball

The Orbit of the Companion to HD 100453A: Binary-Driven Spiral Arms in a Protoplanetary Disk

HD 100453AB is a 10+/-2 Myr old binary whose protoplanetary disk was recently revealed to host a global two-armed spiral structure. Given the relatively small projected separation of the binary (1.05", or ~108 au), gravitational perturbations by the binary seemed to be a likely driving force behind the formation of the spiral arms. However, the orbit of these stars remained poorly understood, which prevented a proper treatment of the dynamical influence of the companion on the disk. We observed HD 100453AB between 2015-2017 utilizing extreme adaptive optics systems on the Very Large Telescope and Magellan Clay Telescope. We combined the astrometry from these observations with published data to constrain the parameters of the binary's orbit to a=1.06"+/-0.09", e=0.17+/-0.07, and i=32.5+/- 6.5 degrees. We utilized publicly available ALMA CO data to constrain the inclination of the disk to i~28 degrees, which is relatively co-planar with the orbit of the companion and consistent with previous estimates from scattered light images. Finally, we input these constraints into hydrodynamical and radiative transfer simulations to model the structural evolution of the disk. We find that the spiral structure and truncation of the circumprimary disk in HD 100453 are consistent with a companion-dirven origin. Furthermore, we find that the primary star's rotation, its outer disk, and the companion exhibit roughly the same direction of angular momentum, and thus the system likely formed from the same parent body of material.Comment: 28 pages, 11 figures, Accepted to Ap

PACES: Promoting Advancement through a Culture of Encouragement and Support

This poster describes the progress and lessons learned as a result of newly implemented Faculty Mentoring Program in the School of Liberal Arts (IUPUI

Exile Vol. XV No. 1

POETRY Haiku by John Anderson 2 It\u27s the looking in the mirror by Larry Faso 3 There is a voice in me by Larry Faso 15 We fight along time by Tracy Mac Nab 8 During the night by Tracy Mac Nab 8 Illusion by Phil Cockerille 10 Mexico City \u2759 by Keith McWalter 12 Summer Correspondence II by Lauren Shakely 13 America Sings to Herself and Doesn\u27t Hear by Lauren Shakely 15 eatin crawdads by Bob Martin 14 G. [unattributed*] 16 Finis Coronant Opus [unattributed*] 17 The Droplet Sea by Jeffrey R. Smith 17 The surrounding dismal forest by P. F. Galbraith 18 FICTION The Shadow in his mind by Cem Mehmet Kozlu 4-7 An Excerpt from a Novel in Progress by Dick Devine 19-22 ARTWORK AND ILLUSTRATIONS by Tom Robinson 2, 12, 16, 18 by Bob Tauber 3, 8, 15 by Tom King 7, 9, 13 by Ted Hall 11, 24 by Clare Conrad 14 Mislabeled Fall 196

Expression and regulation of drug transporters in vertebrate neutrophils.

There remains a need to identify novel pro-resolution drugs for treatment of inflammatory disease. To date, there are no neutrophil-specific anti-inflammatory treatments in clinical use, perhaps due to our lack of understanding of how drugs access this complex cell type. Here we present the first comprehensive description and expression of both major classes of drug transporters, SLC and ABC, in resting human blood neutrophils. Moreover, we have studied the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), additionally examining the evolutionary relationship between drug transporters in zebrafish and humans. We anticipate that this will be a valuable resource to the field of inflammation biology and will be an important asset in future anti-inflammatory drug design