22 research outputs found

    Finishing the euchromatic sequence of the human genome

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    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

    Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

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    Excavations at Le Mura di Santo Stefano, Anguillara Sabazia

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    La relazione presenta i risultati degli scavi condotti tra il 1977 e il 1981 presso le imponenti rovine note come Le Mura di Santo Stefano, situate vicino Anguillara Sabazia, appena 3 km a sud del Lago di Bracciano. La fase più antica di occupazione era relativa ad una fattoria di I secolo d.C. Intorno al 200 d.C. viene costruita una serie di strutture, compreso un edificio a pianta rettangolare su tre piani copiosamente decorato con diciannove tipi di marmo, suggerendo così che il complesso avesse un carattere lussuoso, possibilmente parte di un latifundium. Si hanno evidenze di ulteriori attività nel III o inizi IV secolo d.C. Nel IX secolo, dopo un periodo di abbandono, parte del complesso fu convertito nella chiesa di Santo Stefano. L'aula rettangolare fu rioccupata e le restanti rovine usate come cimitero. Si è dedotto che il sito possa aver funzionato come centro di una proprietà medievale, parte della domusculta papale, o in alternativa come un fundus di una struttura monastica. Nell'XI secolo il sito fu abbandonato, dopo ehe i resti di scheletri appartenenti ad almeno 90 individui, e le ossa di tre cani, furono interrati in un pozzo tappato con pezzi di sculture marmoree romane.</jats:p

    Free Will Skepticism and Its Implications: An Argument for Optimism

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    Complete Genome Sequence of Methanobacterium thermoautotrophicum &amp;Delta;H: Functional . . .

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    the ORF-encoded polypeptides are related to sequences with unknown functions, and 496 (27%) have little or no homology to sequences in public databases. Comparisons with Eucarya-, Bacteria-, and Archaea -specific databases reveal that 1,013 of the putative gene products (54%) are most similar to polypeptide sequences described previously for other organisms in the domain Archaea. Comparisons with the Methanococcus jannaschii genome data underline the extensive divergence that has occurred between these two methanogens; only 352 (19%) of M. thermoautotrophicum ORFs encode sequences that are &gt;50% identical to M. jannaschii polypeptides, and there is little conservation in the relative locations of orthologous genes. When the M. thermoautotrophicum ORFs are compared to sequences from only the eucaryal and bacterial domains, 786 (42%) are more similar to bacterial sequences and 241 (13%) are more similar to eucaryal sequences. The bacterial domain-like gene products include the m
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