Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to ipilimumab was associated with the CD16a-V158F high affinity polymorphism. Such activity only appeared relevant in the context of inflamed tumors, explaining the modest response rates observed in the clinical setting. Our data suggest that the activity of anti-CTLA-4 in inflamed tumors may be improved through enhancement of FcγR binding, whereas poorly infiltrated tumors will likely require combination approaches

Manganosite-microwave exfoliated graphene oxide composites for asymmetric supercapacitor device applications

Graphene based materials coupled with transition metal oxides are promising electrode materials in asymmetric supercapacitors owing to their unique properties which include high surface area, good chemical stability, electrical conductivity, abundance, and lower cost profile over time. In this paper a composite material consisting of graphene oxide exfoliated with microwave radiation (mw rGO), and manganosite (MnO) is synthesised in order to explore their potential as an electrode material. The composite material was characterised by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to explore the process occurring at the electrode/electrolyte interface. Long term cyclability and stability were investigated using galvanostatic charge/discharge testing. From the resulting analysis, an asymmetric supercapacitor was constructed with the best composite containing 90% MnO–10% mw rGO (w/w). The device exhibited a capacitance of 0.11 F/cm2 (51.5 F/g by mass) and excellent capacity retention of 82% after 15,000 cycles at a current density of 0.5 A/g

Health and safety perspectives of graphene in wearables and hybrid materials

Health and safety perspectives of graphene in wearables and hybrid material

The Invisible Woman? A comparative study of women's sports coverage in the UK national press before and after the 2012 Olympic Games

While the coverage of women's sport in UK media rises to comparable levels to men's sports during large sporting events like the Olympics, academics agree that “routine” women's sports coverage is under-represented. According to the Women's Sport and Fitness Foundation, “81% of people think that the female athletes at London 2012 make better role models for young girls than other celebrities.” This article examines the representation of women in sport and compares routine coverage of women's sports in the UK national press across a week in February 2012, six months before the London Olympics, with coverage in a week in February 2013, six months after the Olympics, to see if there has been an Olympic “legacy” that increased coverage. It also examines coverage at the same time of year a decade earlier, to see how far, if at all, women's sports coverage in newspapers has progressed. The results suggest that there has been minimal change in everyday coverage of women's sports after the Olympics, and that female athletes continue to be hugely under-represented in the UK pres