Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety.

International audienceIn this Letter, we report a convenient and efficient method for the synthesis of new simplified derivatives of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groups as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine

Food systems transformation in Vietnam – research and collaboration lay the foundation

Vietnam aims to transform its food systems in a transparent, responsible and sustainable manner. To help achieve this, the new CGIAR research initiative “Sustainable Healthy Diets through Food Systems Transformation” (SHiFT) is working with the emerging multi-stakeholder platforms in the country in order to support the planning and implementation of specific activities. This article demonstrates success already achieved

Using a system dynamics framework to assess disease risks of pig value chains in Vietnam

In Vietnam, there are more than 4 million households producing pigs and pork. This accounts for 57% of quantity of meat consumed. One of the most critical constraints to pig production is the presence of animal disease. Pig disease outbreaks are a regular occurrence in various parts of the country, with the industry affected by diseases such as foot and mouth disease, porcine reproductive and respiratory syndrome, classical swine fever, porcine high fever disease, and swine influenza. In addition, food safety issues related to pig diseases and pork-borne diseases have also increasingly become more important concerns for consumers. Recent studies have shown significant changes in consumption behaviour in response to disease outbreaks. For instance, at least half of urban consumers stop consuming pork in times of pig disease epidemics and/or shift consumption to other meat substitutes such as poultry or fish. Disease risks thus have both public health and livelihoods impacts that are important to understand for appropriate policy and practice response. A proposed methodology for investigating disease risks uses a system dynamics analysis framework. System dynamics models are particularly relevant in the study of livestock systems, as they capture the diverse actors and feedbacks present in value chains and their interface with disease risk and behaviour. A system dynamics model is developed that will describe different scenarios of disease risks and the consequences of different interventions to mitigate these risks. Data from a sample of 1000 farmers and value chain actors including all actors in the pig value chain in Vietnam was collected with support from an ACIAR-funded project on Reducing Disease Risks and Improving Food Safety in Smallholder Pig Value Chains in Vietnam. We propose to test the hypotheses that disease risk is affected by type of production system, feeding system and types of feed uses, access to inputs and services, and selected socio-demographic variables associated with farmers and location

Agroforestry - The Most Resilient Farming System for the Hilly Northwest of Vietnam

Over 94% of the land of northwestern Vietnam is classified as sloping. Population growth has exerted pressure on local natural resources, with agricultural expansion on steep slopes resulting in forest degradation, landscape fragmentation and severe environmental consequences. Efforts to restore forest ecosystems have been made by the government, however, as the livelihoods of 80% of the population depend on agriculture, the reconversion of land to forest has proven to be an inappropriate solution. Agroforestry offers a potentially sustainable land-use solution, which could re-establish forests, restore ecosystem services, and stabilize local livelihoods. In this paper, we assess the potential of agroforestry development in the region based on the results of two interrelated surveys conducted in 21 representative villages in six districts of three northwestern provinces: 1) a farming system diagnosis implemented in 17 representative villages; and 2) an agroforestry adoption survey with 210 households practising agroforestry in 14 villages. The analysis was strengthened by four years’ experience in implementing an extensive agroforestry project in the region. The studies focussed on assessing key benefits and constraints of existing farming systems, including agroforestry practices, adopted by farmers and identifying the potential for agroforestry development in the region. The results showed that the dominant farming system in the north-western provinces was monoculture of staple crops on slopes, which provided relatively low economic returns. Soil erosion, land degradation, and water shortages resultant from intensive farming practices were the most significant environmental issues in the area. Tree-based farming systems were rare and mostly a result of spontaneous adoption by farmers. Given the mountainous landscape and the need for soil stabilization, agroforestry was seen by farmers as a viable approach. Improving the existing and adopting new, integrated agroforestry systems were identified as viable ways toward sustainable livelihoods in Northwestern Vietnam

Market-based approaches to food safety and animal health interventions: Lessons from smallholder pig value chains in Vietnam

Food safety and animal health issues are increasingly important constraints to smallholder pig production in Viet Nam. Recent studies have highlighted the significant prevalence of animal disease and food‐borne pathogens inherent within the Vietnamese pig sector. These in turn have important negative livelihoods effects on smallholder pig producers and other value chain actors, as well as important public health impacts. An important research gap is in identifying ex‐ante appropriate market‐based policy responses that take into account the tradeoffs between improved animal health and food safety outcomes and their associated costs for different value chain actors as a means of developing chain‐level solutions for their control. In this paper, we constructed a system dynamics model of the pig value chain that combines a detailed model of herd production and marketing with modules on short‐ and long‐term investment in pig capacity, and decisions by value chain actors to adopt different innovations. The model further highlights the feedbacks between different actors in the chain to identify both the potential entry points for upgrading food safety and animal health as well as potential areas of tension within the chain that may undermine uptake. Model results demonstrate that interventions at nodal levels (e.g. only at farm or slaughterhouse level) are less cost‐effective and sustainable than those that jointly enhance incentives for control across the value chain, as weak links downstream undermine the ability of producers to sustain good health practices

Alcohol Use, Risk Taking, Leisure Activities and Health Care Use Among Young People in Northern Vietnam

Alcohol consumption is associated with a wide range of health and social consequences. It is also associated with a number of risk taking behaviours. These include illicit drug use and unsafe sex.  Alcohol consumption appears to be increasing in Vietnam. The purpose of this paper is to examine the patterns of alcohol consumption and its relationship with a number of other risk taking behaviours amongst young people.  Information was also obtained concerning leisure activities and use of health care. The paper also sets out to examine possible gender differences in relation to alcohol consumption and risk behaviour and to propose the development and implementation of alcohol monitoring and prevention programs in Vietnam.  The study involved a cross-sectional, community survey using a standardised interview.  This was conducted during face-to-face interviews with 1,408 young people aged 10-19 years.  Respondents were recruited randomly through the lists of the households from 12 selected communes in three areas in Northern Vietnam. The findings presented here were part of a larger health risk behaviour survey.  Levels of alcohol use were low. Overall, 16.5% of participants were experienced drinkers, and only 4% of them were current drinkers. Males were significantly more likely than females to report drinking. This study also showed that rates of alcohol consumption were associated with age, education, geographical area, gender, tobacco smoking, involvement in violence, watching television, computer use and playing computer games, wearing safety helmets and use of health services. Alcohol consumption tended to increase with age for both males and females.  Alcohol and its effects on young people are clearly a growing public health issue in Vietnam.  Because of this, more detailed behavioral research should be conducted into the relationship between alcohol consumption and other risky behaviours amongst young people.  It is also recommended that alcohol harm reduction policies should be implemented and integrated into measures to reduce levels of other health problems such as HIV/AIDS and non communicable diseases. Such policies should ideally be evidence-based and evaluated

Selection of Depression Measures for Use among Vietnamese Populations in Primary Care Settings: A Scoping Review

Depression is an important and growing contributor to the burden of disease around the world and evidence suggests the experience of depression varies cross-culturally. Efforts to improve the integration of services for depression in primary care are increasing globally, meaning that culturally valid measures that are acceptable for use in primary care settings are needed. We conducted a scoping review of 27 studies that validated or used 10 measures of depression in Vietnamese populations. We reviewed the validity of the instruments as reported in the studies and qualitatively assessed cultural validity and acceptability for use in primary care. We found much variation in the methods used to validate the measures, with an emphasis on criterion validity and reliability. Enhanced evaluation of content and construct validity is needed to ensure validity within diverse cultural contexts such as Vietnam. For effective use in primary care, measures must be further evaluated for their brevity and ease of use. To identify appropriate measures for use in primary care in diverse populations, assessment must balance standard validity testing with enhanced testing for appropriateness in terms of culture, language, and gender and for acceptability for use in primary care