The Quickly Universally Integrated CubeSat: Rapid Integration for Small Packages

The Quickly Universally Integrated Concept CubeSat platform, or QUIC, is an experimental space mission architecture that intends to address the need for a rapid development path towards flight readiness by standardizing essential engineering aspects of a satellite, such as chassis, avionics, and power systems, while providing an interface that can quickly and readily accept mission payloads. While the smaller form factor and theoretical simplicity of CubeSats have enabled space access at relatively low costs there still exists a very high barrier to success for first-time CubeSat builders. This is especially true in academia where engineering a CubeSat from the ground up is the longest and most difficult part of development compared to preparing the payload, especially in teams without structural, thermal, or electrical analytical expertise. Independent research has also shown that CubeSat missions often suffer from a high rate of failure and lack of replicability due to these challenges being pitted against teams unfamiliar with traditional space systems engineering processes. Furthermore, in a competitive market of space access, supply for launches has begun to outpace the demand, as not enough small satellites can be produced to keep up with traditional methods. By consolidating communication through a universal interface, various payloads can be connected without compatibility issues and clients can program data collection, computation, and transmission to suit their needs with the onboard computer without incurring significant challenges with hardware integration. As QUIC is designed to accelerate prototyping and development, all components would be easily machined or purchased as commercial off the shelf parts, and assembly can be done by even high school students, vastly expanding the range of access for Low Earth Orbit research. It also is not limited to space, as Bronco Space at Cal Poly Pomona will employ the first stages of QUIC for their high-altitude balloon program, the Balloon Launch Assessment Directive for Engineers, or BLADE

BLADE: The Balloon Launch Assessment Directive for Engineers and the Use of the CubeSat Form Factor for an Introductory Systems Engineering Education

The Balloon Launch Assessment Directive for Engineers (BLADE) acts as a hybrid ideas lab and skills development program for undergraduates at Cal Poly Pomona. This program, targeted primarily at incoming first year and transfer students, takes the participants from zero knowledge of the engineering design process and walks them through a simplified yet rigorous pathway. This pathway is based on established Systems Engineering processes and is deployed by having students design a mock Cube Satellite with a unique scientific payload for flight in a high-altitude balloon. This program not only brings together a hands-on approach to merging good engineering processes with conducting new and innovative scientific research, but also illustrates the value of the systems engineering process to mission success for engineering students that would otherwise not be exposed to its principles until the graduate level. By constraining student designs to the 1U CubeSat form factor, it is intended that experiences gained by students taking part in this program may be directly applied to designs for fully-fledged orbital CubeSat missions the university is undertaking. This process is intended to allow for a foundational pathway into space mission development at the undergraduate level at significantly lower programmatic and technical costs

AGR-2 Data Qualification Report for ATR Cycles 149B, 150A, 150B, 151A, and 151B

This report provides the data qualification status of AGR-2 fuel irradiation experimental data from Advanced Test Reactor (ATR) cycles 149B, 150A, 150B, 151A, and 151B), as recorded in the Nuclear Data Management and Analysis System (NDMAS). The AGR-2 data streams addressed include thermocouple temperatures, sweep gas data (flow rate, pressure, and moisture content), and fission product monitoring system (FPMS) data for each of the six capsules in the experiment. A total of 3,307,500 5-minute thermocouple and sweep gas data records were received and processed by NDMAS for this period. There are no AGR-2 data for cycle 150A because the experiment was removed from the reactor. Of these data, 82.2% were determined to be Qualified based on NDMAS accuracy testing and data validity assessment. There were 450,557 Failed temperature records due to thermocouple failures, and 138,528 Failed gas flow records due to gas flow cross-talk and leakage problems that occurred in the capsules after cycle 150A. For FPMS data, NDMAS received and processed preliminary release rate and release-to-birth rate ratio (R/B) data for the first three reactor cycles (cycles 149B, 150B, and 151B). This data consists of 45,983 release rate records and 45,235 R/B records for the 12 radionuclides reported. The qualification status of these FPMS data has been set to In Process until receipt of QA-approved data generator reports. All of the above data have been processed and tested using a SAS®-based enterprise application software system, stored in a secure Structured Query Language database, and made available on the NDMAS Web portal (http://ndmas.inl.gov) for both internal and external VHTR project participants

Bisphosphonate's and Intermittent Parathyroid Hormone's Effect on Human Spinal Fusion: A Systematic Review of the Literature.

There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate and intermittent parathyroid hormone (PTH) therapy become more widely prescribed to treat osteoporosis, it is important to understand their effects on other physiologic processes, particularly the impact on spinal fusion. Despite early animal model studies and more recent clinical studies, the impact of these medications on spinal fusion is not fully understood. Previous animal studies suggest that bisphosphonate therapy resulted in inhibition of fusion mass with impeded maturity and an unknown effect on biomechanical strength. Prior animal studies demonstrate an improved fusion rate and fusion mass microstructure with the use of intermittent PTH. The purpose of this study was to determine if bisphosphonates and intermittent PTH treatment have impact on human spinal fusion. A systematic review of the literature published between 1980 and 2015 was conducted using major electronic databases. Studies reporting outcomes of human subjects undergoing 1, 2, or 3-level spinal fusion while receiving bisphosphonates and/or intermittent PTH treatment were included. The results of relevant human studies were analyzed for consensus on the effects of these medications in regards to spinal fusion. There were nine human studies evaluating the impact of these medications on spinal fusion. Improved fusion rates were noted in patients receiving bisphosphonates compared to control groups, and greater fusion rates in patients receiving PTH compared to control groups. Prior studies involving animal models found an improved fusion rate and fusion mass microstructure with the use of intermittent PTH. No significant complications were demonstrated in any study included in the analysis. Bisphosphonate use in humans may not be a deterrent to spinal fusion. Intermittent parathyroid use has shown early promise to increase fusion mass in both animal and human studies but further studies are needed to support routine use

Tourism destination modelling: building a sustainable planning tool for Australian tourism destinations

The Ningaloo Destination Model is a tourism planning tool for the Ningaloo Coast region of Western Australia that assesses the economic, social and environmental impacts of different planning decisions and events. This report describes the features of the tourism destination model, and analyses its application in the region and to other parts of Australia. Destination modelling integrates a number of research methodologies developed through past STCRC projects (on visitor spending and characteristics, social impacts and economic impacts), secondary data and ecological research. The key to this process is a model development technique that uses scenario planning methodologies to facilitate stakeholder engagement and conceptual modelling techniques to facilitate research integration. The report describes the methodologies used for model development and for data collection, provides two case studies demonstrating outputs, and explores applications of the Ningaloo Destination Model to the region, to other locations and to other sectors. The Ningaloo Destination Model provides estimates of the impacts of plans and events related to tourism in four dimensions: tourism specific; economy; social; and environmental (both resource use and ecological). These outputs are explored through two case studies: a nodal coastal development; and a large resort development. The model can be used for four broad (oftentimes overlapping) categories of assessment: operational planning and decision making for specific organisations and groups (such as local government or agencies that manage land or sea use), regional planning, participatory planning and collaborations and to assist monitoring and evaluation.The Ningaloo Destination Model will be available to the general public (in a limited format) through websites; to agencies through a desktop version; and through integration into a larger model of the region being developed by the CSIRO. Destination modelling is relevant for other tourism destinations and a process for the rapid and cost-effective application of destination modelling is feasible. While much of the data is available, a broader roll-out would require benchmarking of water, electricity and waste data, and developing a wireframe for all tourism destinations. Making destination modelling tools broadly available would significantly broaden the impacts considered in tourism planning and lead to enhancement of desirable effects of tourism development, and early mitigation of negative impacts across Australia. The techniques developed for destination modelling were also found to be applicable to other sectors

``Superfast'' Reaction in Turbulent Flow with Potential Disorder

We explore the regime of ``superfast'' reactivity that has been predicted to occur in turbulent flow in the presence of potential disorder. Computer simulation studies confirm qualitative features of the previous renormalization group predictions, which were based on a static model of turbulence. New renormalization group calculations for a more realistic, dynamic model of turbulence show that the superfast regime persists. This regime, with concentration decay exponents greater than that for a well-mixed reaction, appears to be a general result of the interplay among non-linear reaction kinetics, turbulent transport, and local trapping by potential disorder.Comment: 14 pages. 4 figures. Uses IOP styles. To appear in J. Phys. A: Math. Ge

Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs

We demonstrated that hydrophobic derivatives of the nonsteroidal anti-inflammatory drug (NSAID)flufenamic acid (FA), can be formed into stable nanometer-sized prodrugs (nanoprodrugs) that inhibit the growth of glioma cells, suggesting their potential application as anticancer agent. We synthesized highly hydrophobic monomeric and dimeric prodrugs of FA via esterification and prepared nanoprodrugs using spontaneous emulsification mechanism. The nanoprodrugs were in the size range of 120 to 140 nm and physicochemically stable upon long-term storage as aqueous suspension, which is attributed to the strong hydrophobic interaction between prodrug molecules. Importantly, despite the highly hydrophobic nature and water insolubility, nanoprodrugs could be readily activated into the parent drug by porcine liver esterase, presenting a potential new strategy for novel NSAID prodrug design. The nanoprodrug inhibited the growth of U87-MG glioma cells with IC50 of 20 μM, whereas FA showed IC50 of 100 μM, suggesting that more efficient drug delivery was achieved with nanoprodrugs

Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.

Myostatin (MSTN) is a transforming growth factor-β (TGF-β) family member that normally acts to limit muscle growth. The function of MSTN is partially redundant with that of another TGF-β family member, activin A. MSTN and activin A are capable of signaling through a complex of type II and type I receptors. Here, we investigated the roles of two type II receptors (ACVR2 and ACVR2B) and two type I receptors (ALK4 and ALK5) in the regulation of muscle mass by these ligands by genetically targeting these receptors either alone or in combination specifically in myofibers in mice. We show that targeting signaling in myofibers is sufficient to cause significant increases in muscle mass, showing that myofibers are the direct target for signaling by these ligands in the regulation of muscle growth. Moreover, we show that there is functional redundancy between the two type II receptors as well as between the two type I receptors and that all four type II/type I receptor combinations are utilized in vivo. Targeting signaling specifically in myofibers also led to reductions in overall body fat content and improved glucose metabolism in mice fed either regular chow or a high-fat diet, demonstrating that these metabolic effects are the result of enhanced muscling. We observed no effect, however, on either bone density or muscle regeneration in mice in which signaling was targeted in myofibers. The latter finding implies that MSTN likely signals to other cells, such as satellite cells, in addition to myofibers to regulate muscle homeostasis

The effects of a whey protein and guar gum-containing preload on gastric emptying, glycaemia, small intestinal absorption and blood pressure in healthy older subjects

A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal absorption. This preload also may be useful in the management of postprandial hypotension. We evaluated the effects of a whey protein/guar preload on gastric emptying, glucose absorption, glycaemic/insulinaemic and blood pressure (BP) responses to an oral glucose load. Eighteen healthy older participants underwent measurements of gastric emptying (scintigraphy), plasma glucose and insulin, glucose absorption, superior mesenteric artery (SMA) flow, BP and heart rate (HR) after ingesting a 50 g glucose drink, with or without the preload. The preload reduced plasma glucose (p = 0.02) and serum 3-O-methylglucose (3-OMG) (p = 0.003), and increased plasma insulin (p = 0.03). There was no difference in gastric emptying or BP between the two days. The reduction in plasma glucose on the preload day was related to the reduction in glucose absorption (r = 0.71, p = 0.002). In conclusion, the glucose-lowering effect of the preload may relate to delayed small intestinal glucose absorption and insulin stimulation, rather than slowing of gastric emptying.publishedVersio

Sensing remote nuclear spins

Sensing single nuclear spins is a central challenge in magnetic resonance based imaging techniques. Although different methods and especially diamond defect based sensing and imaging techniques in principle have shown sufficient sensitivity, signals from single nuclear spins are usually too weak to be distinguished from background noise. Here, we present the detection and identification of remote single C-13 nuclear spins embedded in nuclear spin baths surrounding a single electron spins of a nitrogen-vacancy centre in diamond. With dynamical decoupling control of the centre electron spin, the weak magnetic field ~10 nT from a single nuclear spin located ~3 nm from the centre with hyperfine coupling as weak as ~500 Hz is amplified and detected. The quantum nature of the coupling is confirmed and precise position and the vector components of the nuclear field are determined. Given the distance over which nuclear magnetic fields can be detected the technique marks a firm step towards imaging, detecting and controlling nuclear spin species external to the diamond sensor