A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges

Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of signs and symptoms. The present review from interpretation of the literature gives detailed information on the prevalence, definition, causes, diagnostic tests, and medical management of dry eye disease. A number of systems contribute to the physiological integrity of the ocular surface and disruption of system may or may not produce symptoms. Therefore accurate diagnosis of dry eyes with no or minimal disruption of physiological function is necessary. The paper also discusses different colloidal drug delivery systems and current challenges in the development of topical ophthalmic drug delivery systems for treatment of KCS. Due to the wide prevalence and number of factors involved, newer, more sensitive diagnostic techniques and novel therapeutic agents have been developed to provide ocular delivery systems with high therapeutic efficacy. The aim of this review is to provide awareness among the patients, health care professionals, and researchers about diagnosis and treatment of KCS and recent developments and future challenges in management of dry eye disease

Survey on Leaf Disease Detection and Grading using Artificial Neural Network (ANN) and Fuzzy Logic

In Horticulture, leaf sicknesses have become a difficult as it can bring about noteworthy reduction in both quality what is more, amount of agrarian yields. Therefore, robotized acknowledgment of maladies on leaves assumes a vital part in farming segment. This paper bestows a straightforward and computationally capable strategy utilized for leaf infection distinguishing proof and reviewing utilizing advanced picture handling and machine vision innovation. The proposed framework is partitioned into two stages, in first stage the plant is perceived on the premise of the elements of leaf, it incorporates pre-handling of leaf pictures, and highlight extraction taken after by Counterfeit Neural System based preparing and arrangement for acknowledgment of leaf. In second stage the infection present in the leaf is arranged, this procedure incorporates K-Implies based division of abandoned range, highlight extraction of abandoned bit and the ANN based grouping of malady. At that point the infection reviewing is done on the premise of the measure of infection present in the leaf

Truth Discovery in Big Data Social Media Application

In this system first one is “misinformation spread” where a significant number of sources are contributing to false claims, making the identification of truthful claims difficult. For example, on, Instagram, rumors, Twitter scams, and influence bots are common examples of sources colluding, either intentionally or unintentionally, to spread misinformation and obscure the truth. The challenge is “data sparsity” or the “long-tail phenomenon” where a majority of sources only contribute a small number of claims, providing insufficient evidence to determine those sources’ trustworthiness. For example, in the Twitter datasets that we collected during real-world events, more than 90only contributed to a single claim. Third, many current solutions are not scalable to large-scale social sensing events because of the centralized nature of their truth discovery algorithms. We are going develop a Scalable and Robust Truth Discovery (SRTD) scheme to address the above all challenges. In this, the SRTD scheme jointly quantifies both the reliability of sources and the credibility of claims using a principled approach

Flexural analysis of balsa core sandwich composite: failure mechanisms, core grain orientation and padding effect

A comprehensive investigation was undertaken to study failure mechanisms of sandwich composites and their influence on flexural behavior (load-displacement curve). Sandwich composite panels were cured from compression thermoforming of E-glass/epoxy skins and a low density balsa wood core. Balsa core grain orientation is found to have major effect on flexural response and failure modes. Flexural behavior, failure mode and its sequence varies with different core grain orientations. Indentation, skin failure, core shear failure were dominant failure modes observed for various cases. Skin-core interface adhesion was reasonably good, as delamination was not the first failure mode in sandwich beam with balsa core. Indentation of skin is a major concern under localized loading, as the skin failure is premature as compared to its normal compressive strength. Hence, the effect of padding on sandwich beam with soft core was also completed as part of this work. Finite element analysis for modeling this type of sandwich composite beam is conducted using LS-Dyna. Several material parameters required for finite element analysis were determined from extensive testing and data from literature. Composite failure model and wood material model available in LS-Dyna were applied for skin and core of sandwich beam. At the skin-core interface, nodes were merged as delamination was not a prominent failure mode. Flexural analysis response from FEA shows good correlation with experimental behavior

Article A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges

Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of signs and symptoms. The present review from interpretation of the literature gives detailed information on the prevalence, definition, causes, diagnostic tests, and medical management of dry eye disease. A number of systems contribute to the physiological integrity of the ocular surface and disruption of system may or may not produce symptoms. Therefore accurate diagnosis of dry eyes with no or minimal disruption of physiological function is necessary. The paper also discusses different colloidal drug delivery systems and current challenges in the development of topical ophthalmic drug delivery systems for treatment of KCS. Due to the wide prevalence and number of factors involved, newer, more sensitive diagnostic techniques and novel therapeutic agents have been developed to provide ocular delivery systems with high therapeutic efficacy. The aim of this review is to provide awareness among the patients, health care professionals, and researchers about diagnosis and treatment of KCS and recent developments and future challenges in management of dry eye disease

GooDoop: Local Search Engine using Hadoop

Abstract — The advent of web and search engines have made online se arching a common method for obtaining information. With the highly dispersed amount of information internet has become a primary need. Regardless of the same, the frequency of interruption in internet connection is one of the largest on the planet and for an organization in private or for an institution the internet access rates are at formidable ranges. The increasing dependency on such information has created an utter need for an alternative to the existing online search system. The notion of our project “Local search Engine based on Hadoop ” is collection of static informative pages and accessing those information without any internet connection. These static contents are stored on different nodes of the hadoop cluster. For intense processing of large no of static contents we bring in the use of Hadoop platform. Hence conscience behind our project is to collect such web contents at hadoop nodes and to make it available locally without any need of internet to any node present in the network. I

Review Paper On Design And Fabrication Of Hydraulic Groundnut Oil Expeller

A manually operated multi-application oilseed expressing machine was designed and constructed usinglocally available materials. The machine consists of a frame, press plate, press cage, perforated cylinderand hydraulic jack. Each of these components was analyzed and results obtained were used as parameterfor sizing and fabrication of the components. Performance tests were conducted on the oilseed expressingmachine using groundnut seeds that were subjected to pre-pressing treatments of roastingtemperature and duration in the ranges of 30 –120oC and 10 –30 min and ground in to pastesrespectively. The results of performance test analysis showed that pre-pressing treatments significantlyinfluenced the performance indices of the machine at 1% level. Extraction rate decreased with increase inroasting temperature from30 to 120oC and duration from 10 to 30 min, while machine extractionefficiency depended on the product being processed. The maximum extraction rate obtained was 0.00125and 0.00133 kg/s for groundnut seeds roasted at 60oC for 10min and 30oC for 10 minrespectively. The maximum extraction efficiency of 45 and 46.6% was obtained at pre-pressin

Neutral wetting brush layers for block copolymer thin films using homopolymer blends processed at high temperatures

Binary homopolymer blends of two hydroxyl-terminated polystyrene (PS-OH) and polymethylmethacrylate (PMMA-OH) homopolymers (Mn similar to 16000 g mol(-1)) were grafted on SiO2 substrates by high-temperature (T > 150 degrees C), short-time (t < 600 s) thermal treatments. The resulting brush layer was tested to screen preferential interactions of the SiO2 substrate with the different symmetric and asymmetric PS-b-PMMA block copolymers deposited on top of the grafted molecules. By properly adjusting the blend composition and the processing parameters, an efficient surface neutralization path was identified, enabling the formation, in the block copolymer film, of homogeneous textures of lamellae or cylinders perpendicularly oriented with respect to the substrate. A critical interplay between the phase segregation of the homopolymer blends and their grafting process on the SiO2 was observed. In fact, the polar SiO2 is preferential for the PMMA-rich phase that forms a homogeneous layer on the substrate, while the PS-rich phase is located at the polymer-air interface. During the thermal treatment, phase segregation and grafting proceed simultaneously. Complete wetting of the PS rich phase on the PMMA rich phase leads to the formation of a PS/PMMA bilayer. In this case, the progressive diffusion of PS chains toward the polymer-SiO2 interface during the thermal treatment allows tuning of the brush layer composition

Neutral wetting brush layers for block copolymer thin films using homopolymer blends processed at high temperatures

Binary homopolymer blends of two hydroxyl-terminated polystyrene (PS-OH) and polymethylmethacrylate (PMMA-OH) homopolymers (Mn ∼ 16000 g mol(-1)) were grafted on SiO2 substrates by high-temperature (T > 150 °C), short-time (t < 600 s) thermal treatments. The resulting brush layer was tested to screen preferential interactions of the SiO2 substrate with the different symmetric and asymmetric PS-b-PMMA block copolymers deposited on top of the grafted molecules. By properly adjusting the blend composition and the processing parameters, an efficient surface neutralization path was identified, enabling the formation, in the block copolymer film, of homogeneous textures of lamellae or cylinders perpendicularly oriented with respect to the substrate. A critical interplay between the phase segregation of the homopolymer blends and their grafting process on the SiO2 was observed. In fact, the polar SiO2 is preferential for the PMMA-rich phase that forms a homogeneous layer on the substrate, while the PS-rich phase is located at the polymer-air interface. During the thermal treatment, phase segregation and grafting proceed simultaneously. Complete wetting of the PS rich phase on the PMMA rich phase leads to the formation of a PS/PMMA bilayer. In this case, the progressive diffusion of PS chains toward the polymer-SiO2 interface during the thermal treatment allows tuning of the brush layer composition