Massive spin 2 propagator on de Sitter space

We compute the Pauli-Jordan, Hadamard and Feynman propagators for the massive metrical perturbations on de Sitter space. They are expressed both in terms of mode sums and in invariant forms.Comment: 30 pages + 1 eps fi

Classical diffusion of N interacting particles in one dimension: General results and asymptotic laws

I consider the coupled one-dimensional diffusion of a cluster of N classical particles with contact repulsion. General expressions are given for the probability distributions, allowing to obtain the transport coefficients. In the limit of large N, and within a gaussian approximation, the diffusion constant is found to behave as N^{-1} for the central particle and as (\ln N)^{-1} for the edge ones. Absolute correlations between the edge particles increase as (\ln N)^{2}. The asymptotic one-body distribution is obtained and discussed in relation of the statistics of extreme events.Comment: 6 pages, 2 eps figure

Chiral supersymmetric pp-wave solutions of IIA supergravity

We describe solutions of type IIA (N=2, D=10) supergravity built under the assumption of the existence of at least one residual chiral supersymmetry. Their geometry is of pp-wave type. Explicit parametrization of the metric and matter field components, in terms of Killing spinors and arbitrary functions, is provided.Comment: LaTeX file, 10 page

Automated glycan assembly of a S. pneumoniae serotype 3 CPS antigen

Vaccines against S. pneumoniae, one of the most prevalent bacterial infections causing severe disease, rely on isolated capsular polysaccharide (CPS) that are conjugated to proteins. Such isolates contain a heterogeneous oligosaccharide mixture of different chain lengths and frame shifts. Access to defined synthetic S. pneumoniae CPS structures is desirable. Known syntheses of S. pneumoniae serotype 3 CPS rely on a time-consuming and low-yielding late-stage oxidation step, or use disaccharide building blocks which limits variability. Herein, we report the first iterative automated glycan assembly (AGA) of a conjugation-ready S. pneumoniae serotype 3 CPS trisaccharide. This oligosaccharide was assembled using a novel glucuronic acid building block to circumvent the need for a late-stage oxidation. The introduction of a washing step with the activator prior to each glycosylation cycle greatly increased the yields by neutralizing any residual base from deprotection steps in the synthetic cycle. This process improvement is applicable to AGA of many other oligosaccharides

A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time

BACKGROUND: Determination of clot lysis times on whole blood, diluted whole blood, plasma or plasma fraction has been used for many years to assess the overall activity of the fibrinolytic system. We designed a completely computerised semi-automatic 8-channel device for measurement and determination of fibrin clot lysis. The lysis time is evaluated by a mathematical analysis of the lysis curve and the results are expressed in minute (range: 5 to 9999). We have used this new device for Euglobulin Clot Lysis Time (ECLT) determination, which is the most common test used in laboratories to estimate plasma fibrinolytic capacity. RESULTS: The correlation between ECLT and manual method is very tight : R = 0,99; p < 10(-6). The efficiency scores of the method are <4% in intra-assay and <7% in inter-assay. It allows to achieve the tests on hyperlipaemic samples. This new device has been easily integrated in laboratory routine and allows to achieve several ECLT every day without disturbance of laboratory workflow. CONCLUSIONS: The routine use of this new device could be useful in various situations such as assessment in atherosclerosis and arteriosclerosis associated diseases, coagulation survey of liver transplantations, cardiovascular surgery or pharmacological research. It has already provided highly promising results in preliminary studies on the relation between fibrinolysis and cardiovascular risk factors

A comparison of intimate partner violence and associated physical injuries between cohabitating and married women: a 5-year medical chart review

published_or_final_versio

Decision for reconstructive interventions of the upper limb in individuals with tetraplegia: the effect of treatment characteristics

Objective: To determine the effect of treatment characteristics on the\ud decision for reconstructive interventions for the upper extremities (UE) in\ud subjects with tetraplegia. - \ud Setting: Seven specialized spinal cord injury centres in the Netherlands. - \ud Method: Treatment characteristics for UE reconstructive interventions were\ud determined. Conjoint analysis (CA) was used to determine the contribution\ud and the relative importance of the treatment characteristics on the decision\ud for therapy. Therefore, a number of different treatment scenarios using these\ud characteristics were established. Different pairs of scenarios were presented\ud to subjects who were asked to choose the preferred scenario of each set. - \ud Results: forty nine subjects with tetraplegia with a stable C5, C6 or C7\ud lesion were selected. All treatment characteristics significantly influenced\ud the choice for treatment. Relative importance of treatment characteristics\ud were: intervention type (surgery or surgery with FES implant) 13%, number\ud of operations 15%, in patient rehabilitation period 22%, ambulant\ud rehabilitation period 9%, complication rate 15%, improvement of elbow\ud function 10%, improvement of hand function 15%. In deciding for therapy\ud 40% of the subjects focused on one characteristic. - \ud Conclusion: CA is applicable in Spinal Cord Injury medicine to study the\ud effect of health outcomes and non-health outcomes on the decision for\ud treatment. Non-health outcomes which relate to the intensity of treatment\ud are equally important or even more important than functional outcome in the\ud decision for reconstructive UE surgery in subjects with tetraplegia

Quantum charged fields in Rindler space

We study, using Rindler coordinates, the quantization of a charged scalar field interacting with a constant, external, electric field. First we establish the expression of the Schwinger vacuum decay rate, using the operator formalism. Then we rederive it in the framework of the Feynman path integral method. Our analysis reinforces the conjecture which identifies the zero winding sector of the Minkowski propagator with the Rindler propagator. Moreover we compute the expression of the Unruh's modes that allow to make connection between Minkowskian and Rindlerian quantization scheme by purely algebraic relations. We use these modes to study the physics of a charged two level detector moving in an electric field whose transitions are due to the exchange of charged quanta. In the limit where the Schwinger pair production mechanism of the exchanged quanta becomes negligible we recover the Boltzman equilibrium ratio for the population of the levels of the detector. Finally we explicitly show how the detector can be taken as the large mass and charge limit of an interacting fields system.Comment: 1 Tex file + 5 eps figure

Mimimal Length Uncertainty Principle and the Transplanckian Problem of Black Hole Physics

The minimal length uncertainty principle of Kempf, Mangano and Mann (KMM), as derived from a mutilated quantum commutator between coordinate and momentum, is applied to describe the modes and wave packets of Hawking particles evaporated from a black hole. The transplanckian problem is successfully confronted in that the Hawking particle no longer hugs the horizon at arbitrarily close distances. Rather the mode of Schwarzschild frequency $\omega$ deviates from the conventional trajectory when the coordinate $r$ is given by $| r - 2M|\simeq \beta_H \omega / 2 \pi$ in units of the non local distance legislated into the uncertainty relation. Wave packets straddle the horizon and spread out to fill the whole non local region. The charge carried by the packet (in the sense of the amount of "stuff" carried by the Klein--Gordon field) is not conserved in the non--local region and rapidly decreases to zero as time decreases. Read in the forward temporal direction, the non--local region thus is the seat of production of the Hawking particle and its partner. The KMM model was inspired by string theory for which the mutilated commutator has been proposed to describe an effective theory of high momentum scattering of zero mass modes. It is here interpreted in terms of dissipation which gives rise to the Hawking particle into a reservoir of other modes (of as yet unknown origin). On this basis it is conjectured that the Bekenstein--Hawking entropy finds its origin in the fluctuations of fields extending over the non local region.Comment: 12 pages (LateX), 1 figur

Survey of the needs of patients with spinal cord injury: impact and priority for improvement in hand function in tetraplegics\ud

Objective: To investigate the impact of upper extremity deficit in subjects with tetraplegia.\ud \ud Setting: The United Kingdom and The Netherlands.\ud \ud Study design: Survey among the members of the Dutch and UK Spinal Cord Injury (SCI) Associations.\ud \ud Main outcome parameter: Indication of expected improvement in quality of life (QOL) on a 5-point scale in relation to improvement in hand function and seven other SCI-related impairments.\ud \ud Results: In all, 565 subjects with tetraplegia returned the questionnaire (overall response of 42%). Results in the Dutch and the UK group were comparable. A total of 77% of the tetraplegics expected an important or very important improvement in QOL if their hand function improved. This is comparable to their expectations with regard to improvement in bladder and bowel function. All other items were scored lower.\ud \ud Conclusion: This is the first study in which the impact of upper extremity impairment has been assessed in a large sample of tetraplegic subjects and compared to other SCI-related impairments that have a major impact on the life of subjects with SCI. The present study indicates a high impact as well as a high priority for improvement in hand function in tetraplegics.\ud \u