A Linear Model For Moving Measurements Estimation In Urban Climate Studies

Problem statement: Several methods can be adopted to study the variations in urban climate. The mobile measurement method is one of them, involving information provided by moving measurements of air temperature, that are taken in points defined along pre-established routes and also data from fixed-point temperature recording stations. Because moving measurements are made in different times along the measurement process, adjustments must be made in order to adequately analyze the air temperature measurements. Approach: Mobile measurements were taken in an urban area and contextualized in the domain of some fixed-point temperature recording stations. Therefore, a linear model proposed to investigate and represent the variables that influence moving measurements estimation in the urban context. Results: All proposed variables in the linear model were considered relevant, because all coefficients of the determined model were non null. Also, the identified model presents a good fit to the field data, as indicated by the resulting coefficient of determination (R2) that is 90.3%. Conclusion/Recommendations: The linear model described in this work is easy to apply, requiring few input variables. It is important to emphasize that the model was developed to estimate moving measurements as a function of fixed measurements and presents the potential to identify new input variables based on moving measurements, as shown by the fit among fixed and moving temperature measurements, in order to provide insight about other possible models of late time adjustment.© 2011 Science Publications.87685690Beeson, C., Blumberg, D., Brazel, A., Shashuabar, L., Combined Methods of Thermal Remote Sensing and Mobile Climate Transects In Beer Sheva, Israel (2005) Proceedings of the ISPRS joint conference, pp. 21-26. , http://www.isprs.org/proceedings/XXXVI/8-W27, Editors: M. Moeller and E. Wentz, ISPRS WG VIII/1 "Human Settlements and Impact Analysis, Mar. 14-16, Tempe, AZ, USACharabi, Y., Bakhit, A., Assessment of the canopy urban heat island of a coastal arid tropical city: The case of Muscat, Oman (2011) Atmospheric Res, 101, pp. 215-227. , DOI: 10.1016/j.atmosres.2011.02.010(2011) Urban Development and Environment, , http://2009.campinas.sp.gov.br/seplama/deplan/deplan.htm, City Secretariat of PlanningDanazumi, S., Shamsudin, S., Aris, A., Modeling the distribution of rainfall intensity using hourly data (2010) Am. J. Environ. Sci, 6, pp. 238-243. , DOI: 10.3844/ajessp.2010.238.243El-Nesr, M.N., Abu-Zreig, M.M., Alazba, A.A., Temperature trends and distribution in the Arabian peninsula (2010) Am. J. Environ. Sci, 6, pp. 191-203. , DOI: 10.3844/ajessp.2010.191.203Kaiser, I.M., Faria, J.R.G., Validation of Transects For Air Temperature and Moisture Profiles Measurements In Urban Areas Under High Diurnal Air Temperatures Variation (2001) Proceedings of the 18 th Conference On Passive and Low Energy Architecture, pp. 571-575. , http://www.arct.cam.ac.uk/PLEA/Conference.aspx?p=9&ix=10&pid=2&prcid=33&ppid=522, Organizing Committee of PLEA'2001, Brazil Florianópolis Nov. 7-9Kudish, A.I., Evseev, E.G., The assessment of four different correction models applied to the diffuse radiation measured with a shadow ring using global and normal beam radiation measurements for Beer Sheva, Israel (2007) Solar Energy, 82, pp. 144-156. , DOI: 10.1016/j.solener.2007.06.006Lee, E., Sharples, S., An Analysis of the Urban Heat Island of Sheffield- the Impact of a Changing Climate (2008) Proceedings of the 25th Conference On Passive and Low Energy Architecture, p. 396. , http://architecture.ucd.ie/Paul/PLEA2008/content/index.html, Oct. 22-24, University College Dublin, Dublin, SessionMirzaei, P.A., Haghighat, F., Approaches tostudy Urban Heat Island-Abilities and limitations (2010) Buil. Environ, 45, pp. 2192-2201. , DOI: 10.1016/j.buildenv.2010.04.001Mota, A.A., Mota, L.T.M., Pezzuto, C.C., Object oriented modeling of thermostatically controlled devices for cold load pick-up (2011) J. Comput. Sci, 7, pp. 262-269. , DOI:10.3844/jcssp.2011.262.269Murphy, D.J., Hall, M.H., Hall, C.A.S., Heisler, G.M., Stehman, S.V., The relationship between land cover and the urban heat island in northeastern Puerto Rico (2011) Int. J. Climatol, 31, pp. 1099-1256. , DOI: 10.1002/joc.2145Nagara, K., Shimoda, Y., Mizuno, M., Evaluation of the thermal environment in an outdoor pedestrian space (1996) Atmospheric Environ, 30, pp. 497-505. , DOI: 10.1016/1352-2310(94)00354-8Oke, T.R., (2006) Initial Guidance to Obtain Representative Meteorological Observations At Urban Sites, p. 1250. , http://www.wmo.int/pages/prog/www/IMOP/publications/IOM-81/IOM-81-UrbanMetObs.pdf, World Meteorological Organization. Instruments and Observing Methods Report No 81 WMO/TD-N°Pezzuto, C.C., Labaki, L.C., Filho, L.L.F., Urban Environment Analysis Through Mobile Measurements and City Maps: Example In Campinas, Brazil (2006) Proceedings of the 6 th International Conference On Urban Climate, International Association For Urban Climate (IAUC), pp. 505-508. , http://www.urbanclimate.org/, June 12-16, World Meteorological Organization and Goteborg University, Goteborg Sweden, ppRahnama-Rad, J., Bavali, M.Y., Derakhshani, R., Optimization of hydraulic parameters of iranshahr alluvial aquifer (2010) Am. J. Environ. Sci, 6, pp. 477-483. , DOI: 10.3844/ajessp.2010.477.483Sun, C.Y., Brazel, A.J., Chow, W.T.L., Hedquist, B.C., Prashad, L., Desert heat island study in winter by mobile transect and remote sensing techniques (2009) Theoretical Applied Climatol, 98, pp. 323-335. , DOI: 10.1007/s00704-009-0120-2Thongwan, T., Kangrang, A., Homwuttiwong, S., An estimation of rainfall using fuzzy setgenetic algorithms model (2011) Am. J. Eng. Applied Sci, 4, pp. 77-81. , DOI:10.3844/ajeassp.2011.77.81Vicente-Serrano, S.M., Cuadrat-Prats, J., Saz-Sanchez, M., Spatial patterns of the urban heat island in Zaragoza (Spain) (2005) Climate Res, 30, pp. 61-69. , DOI: 10.3354/cr03006

A transcribed enhancer dictates mesendoderm specification in pluripotency.

Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification. We sort mesendodermal progenitors from differentiating embryonic stem cells (ESCs) according to Eomes expression, and find that enhancer usage is coordinated with mesendoderm-specific expression of key lineage-determining transcription factors. Many of these enhancers are associated with the expression of lncRNAs. Examination of ESC-specific enhancers interacting in three-dimensional space with mesendoderm-specifying transcription factor loci identifies MesEndoderm Transcriptional Enhancer Organizing Region (Meteor). Genetic and epigenetic manipulation of the Meteor enhancer reveal its indispensable role during mesendoderm specification and subsequent cardiogenic differentiation via transcription-independent and -dependent mechanisms. Interestingly, Meteor-deleted ESCs are epigenetically redirected towards neuroectodermal lineages. Loci, topologically associating a transcribed enhancer and its cognate protein coding gene, appear to represent therefore a class of genomic elements controlling developmental competence in pluripotency

Antiepileptic drug discontinuation by people with epilepsy in the general population

Objective: Rate, reasons, and predictors of antiepileptic drug (AED) discontinuation were investigated in a well-defined cohort of people with epilepsy to verify efficacy and tolerability of treatment up to 20 years from treatment initiation. Methods: The history of AED usage in children and adults with epilepsy registered with 123 family physicians in an area of Northern Italy between 2000 and 2008 was recorded. Cumulative probabilities of AED withdrawal for specific reasons were estimated using cumulative incidence functions. The probabilities of withdrawing for terminal remission, and of achieving sustained remission while still on treatment, were also evaluated. The roles of sex, age at diagnosis, seizure types, duration at diagnosis, and syndrome were assessed with hazard ratios and 95% confidence intervals. Results: Seven hundred thirty-one of 747 individuals were treated with one or more AEDs during the disease course. The three commonest drugs were valproate, carbamazepine, and phenobarbital. Reported reasons for AED withdrawal were, in decreasing order, terminal remission, ineffectiveness, and adverse events. The probability of withdrawing the first AED for terminal remission was 1.0% at 1 year and increased to 20.0% at 20 years. Corresponding rates were 2.9% and 12.6% for ineffectiveness and 0.5% and 3.3% for adverse events. Reasons for withdrawal varied with individuals' age, sex, disease characteristics, and drugs. Significance: The initial AED given was retained in the majority of cases. Terminal remission, lack of efficacy, and adverse effects were, in decreasing order, the commonest reasons for AED discontinuation. Withdrawal could be predicted by age at diagnosis, sex, and clinical characteristics and varies among drugs

Long-term prognosis of epilepsy, prognostic patterns and drug resistance : a population-based study

Background and purpose: Seizures in most people with epilepsy remit but prognostic markers are poorly understood. There is also little information on the long-term outcome of people who fail to achieve seizure control despite the use of two antiepileptic drugs (drug resistance). Methods: People with a validated diagnosis of epilepsy in whom two antiepileptic drugs had failed were identified from primary care records. All were registered with one of 123 family physicians in an area of northern Italy. Remission (uninterrupted seizure freedom lasting 2 years or longer) and prognostic patterns (early remission, late remission, remission followed by relapse, no remission) were determined. Results: In all, 747 individuals (381 men), aged 11 months to 94 years, were followed for 11 045.5 person-years. 428 (59%) were seizure-free. The probability of achieving 2-year remission was 18% at treatment start, 34% at 2 years, 45% at 5, 52% at 10 and 67% at 20 years (terminal remission, 60%). Epilepsy syndrome and drug resistance were the only independent predictors of 2- and 5-year remission. Early remission was seen in 101 people (19%), late remission in 175 (33%), remission followed by relapse in 85 (16%) and no remission in 166 (32%). Treatment response was the only variable associated with differing prognostic patterns. Conclusion: The long-term prognosis of epilepsy is favourable in most cases. Early seizure remission is not invariably followed by terminal remission and seizure outcome varies according to well-defined patterns. Prolonged seizure remission and prognostic patterns can be predicted by broad syndromic categories and the failure of two antiepileptic drugs

Euclid. I. Overview of the Euclid mission

International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance

Euclid. I. Overview of the Euclid mission

International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance

Euclid. I. Overview of the Euclid mission

The current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance

Euclid. I. Overview of the Euclid mission

International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance