Extended brief intervention to address alcohol misuse in people with mild to moderate intellectual disabilities living in the community (EBI-ID): study protocol for a randomised controlled trial.

There is some evidence that people with intellectual disabilities who live in the community are exposed to the same risks of alcohol use as the rest of the population. Various interventions have been evaluated in the general population to tackle hazardous or harmful drinking and alcohol dependence, but the literature evaluating interventions is very limited regarding intellectual disabilities. The National Institute for Health and Clinical Excellence recommends that brief and extended brief interventions be used to help young persons and adults who have screened as positive for hazardous and harmful drinking. The objective of this trial is to investigate the feasibility of adapting and delivering an extended brief intervention (EBI) to persons with mild/moderate intellectual disability who live in the community and whose level of drinking is harmful or hazardous

Eficiencia de implantación de trigo con labranza en franjas a distintas velocidades de avance

p.121-127En la implantación de cultivos en siembra directa, la compactación y la presencia de abundante rastrojo, dificultan el desempeño del tren de distribución de las sembradoras. En el presente trabajo se evaluó el comportamiento de una máquina intersembradora que posee rotoabridores que labran una franja de suelo, sobre la cual, los surcadores depositan la simente. La evaluación constituyó: el tratamiento a la semilla dosificada, a la uniformidad de distribución, la profundidad de siembra y la eficiencia de implantación de un cultivo de trigo a tres velocidades de avance. Los resultados mostraron disminución significativa en la semilla dosificada ante incrementos de velocidad, no se observó diferencia en la distribución de la semilla en el terreno, tendencia a una menor profundidad de siembra y significancia en la eficiencia de implantación a favor de la menor velocidad de avance. Se concluye que el desempeño de ésta sembradora sólo es comparable con las técnicas convencionales a la menor velocidad ensayada

Development and evaluation of a manual for extended brief intervention for alcohol misuse for adults with mild to moderate intellectual disabilities living in the community: The EBI-LD study manual

BACKGROUND: Extended brief interventions for alcohol misuse are effective in the general population. The process of manualising the first ever such intervention for people with mild to moderate intellectual disabilities in the UK is the focus of this study. METHODS: The manual was an adaptation of existing manuals based on Motivational Enhancement and Cognitive Behaviour Therapy and was used in a feasibility randomized controlled trial, the EBI-LD study. The sessions were recorded and scored using an adapted version of the Yale Adherence and Competence Scale (YACS II). Feedback was provided by therapists. The trial is closed. Registered: isrctn.com; ISRCTN58783633. RESULTS: The quality of the sessions provided was rated as good. Therapists were able to cover all topics within each session. Main challenges included session duration and homework task completion. CONCLUSIONS: We recommend the duration of the sessions to be extended to 40 min to accommodate carers in the session and to enhance their support in homework task completion

The polo-like kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia

CD56 is expressed in 15–20% of acute myeloid leukaemias (AML) and is associated with extramedullary diffusion, multidrug resistance and poor prognosis. We describe the establishment and characterisation of a novel disseminated model of AML (AML-NS8), generated by injection into mice of leukaemic blasts freshly isolated from a patient with an aggressive CD56+ monoblastic AML (M5a). The model reproduced typical manifestations of this leukaemia, including presence of extramedullary masses and central nervous system involvement, and the original phenotype, karyotype and genotype of leukaemic cells were retained in vivo. Recently Polo-Like Kinase 1 (PLK1) has emerged as a new candidate drug target in AML. We therefore tested our PLK1 inhibitor NMS-P937 in this model either in the engraftment or in the established disease settings. Both schedules showed good efficacy compared to standard therapies, with a significant increase in median survival time (MST) expecially in the established disease setting (MST = 28, 36, 62 days for vehicle, cytarabine and NMS-P937, respectively). Importantly, we could also demonstrate that NMS-P937 induced specific biomarker modulation in extramedullary tissues. This new in vivo model of CD56+ AML that recapitulates the human tumour lends support for the therapeutic use of PLK1 inhibitors in AML

\u201cIl meccanismo della falsificazione e della perversione nel pensiero auto lesivo\u201d

Questo lavoro tenta di dimostrare che l\u2019autolesionismo \ue8 caratterizzato dalla perversione e dalla falsificazione. Viene proposto il caso di una giovane donna ricoverata in un reparto psichiatrico che presenta un comportamento autolesivo. Attraverso meccanismi di idealizzazione e di negazione la paziente attua una falsificazione della realt\ue0 e del pensiero. La gravit\ue0 e la profondit\ue0 del disturbo impediscono alla paziente di utilizzare adeguatamente la metafora (il pensiero metaforico). Viene proposto un confronto con il concetto di bugia, seguendo le indicazioni di Bion. This study suggests that self-injury is characterized by perversion and by falsification. We report the case of a young woman hospitalized in a psychiatric department, who presented self-injurious behaviour. Through mechanisms of idealization and negation the patient effects a falsification of reality and thought. The severity and depth of her disorders prevent the patient from adequately using metaphoric thought. We propose a comparison with the concept of lie,on the basis of Bion\u2019s theories