54 research outputs found
Reusable Space Vehicle Ground Operations Baseline Conceptual Model
Modeling efforts for future space operation vehicles at the United States Air Force Research Labs Air Vehicles Directorate have been focused towards the in-flight mission. To better serve the research and development effort, a simulation of the ground operations is required allowing for trade-offs within turnaround operations and between the components that drive those procedures. However, before a simulation can be developed a conceptual model must be generated to guide the model building process. This research provides a baseline conceptual model for reusable space vehicles based on the space shuttle as the only operational vehicle of its kind. The model is built utilizing the Integrated Definition (IDEF) methodology, specifically IDEF3. IDEF3 is focused towards process-viewpoint diagramming and layout. The model is developed using the hierarchical development capabilities of the IDEF3 methodology and is broken into modules allowing for greater reuse and usability. This model captures the scheduled maintenance performed to turnaround the space shuttle for the next launch but does not contain every activity. The idea was to capture the baseline activities that may be found in future Reusable Space Vehicles and provide a description of what happens at Kennedy Space Center when preparing the space shuttle for the next launch
Demographic and temporal variations in immunity and condition of polar bears (\u3ci\u3eUrsus maritimus\u3c/i\u3e) from the southern Beaufort Sea
Assessing the health and condition of animals in their natural environment can be problematic. Many physiological metrics, including immunity, are highly influenced by specific context and recent events to which researchers may be unaware. Thus, using a multifaceted physiological approach and a context-specific analysis encompassing multiple time scales can be highly informative. Ecoimmunological tools in particular can provide important indications to the health of animals in the wild.We collected blood and hair samples from free-ranging polar bears (Ursus maritimus) in the southern Beaufort Sea and examined the influence of sex, age, and reproductive status on metrics of immunity, stress, and body condition during 2013–2015.We examined metrics of innate immunity (bactericidal ability and lysis) and stress (hair cortisol, reactive oxygen species, and oxidative barrier), in relation to indices of body condition considered to be short term (urea to creatinine ratio; UC ratio) and long term (storage energy and body mass index). We found the factors of sex, age, and reproductive status of the bear were critical for interpreting different physiological metrics. Additionally, the metrics of body condition were important predictors for stress indicators. Finally,many of these metrics differed between years, illustrating the need to examine populations on a longer time scale. Taken together, this study demonstrates the complex relationship between multiple facets of physiology and how interpretation requires us to examine individuals within a specific context
The Ursinus Weekly, January 17, 1966
Y speaker on Vietnam assails US policy • PSEA hears advice from student teachers • Alumni invite U.C. seniors to gala at Bala • Ursinus Plan, part 2: Detailed explanation of new curricular program • U.C. receives $2,500 grant • Lorelei sirens seek out male campus element • Alumni Centennial corner • Editorial: We get letters? Only wish we did! • Letters to the editor • Editors, professor applaud maiden publication of Focus: All cite necessity for participation of student body • Only seven can secure greatest Ursinus honor : Cub and Key to induct at Prom • Intramural corner • Wrestlers strangle H\u27ford, Albright: Shut out Fords 37-0, Drop Albright 20-9 • Troster leads Bears over Dickinson: UC bounces back after losing to H\u27ford • Greek gleanings • Are students destructive? Not often, but accidents happen in dorms, labs: Boys will be boys sometimes, thoughhttps://digitalcommons.ursinus.edu/weekly/1215/thumbnail.jp
The Ursinus Weekly, January 10, 1966
Senate urges reading period before exams • The Freeland story • The Ursinus plan: To advance the quality of education at UC • UC receives $25,000 grant • Alumni fund hits new peak in contributions • Lantern contest proclaims winners • Roster changes • Examination schedule • We\u27ll not forget: A promise to Freeland; Old building to be razed to provide Library site • A senior\u27s view of Freeland: Can Library replace Freeland\u27s primacy? • An alumnus\u27 view of Freeland: Alumnus recalls Freeland as source of campus activities • Search into Ursinus history substantiates second oldest graduate\u27s assertion: Yes, Freeland was indeed everything • Delaware flattens UC: Rivell, Struthers only winners • Bears crush S\u27more; Fall to PMC • Intramural corner • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1214/thumbnail.jp
The Ursinus Weekly, April 30, 1951
Nominations made for class, MSGA elections • Coeds elect new student council representatives • Y to organize; Retreat slated • Senior dinner planned • Professors\u27 panel set for Wednesday night • Beemer, Mras get waiter posts • Arsenic rehearsal speeded up as performance nears • Varsity show called amusing • Turk to speak here Tuesday • Jobs open for spring graduates • Senior group works hard preparing papers for departmental honors • Editorials: Attention, W.S.G.A.! • Are we prey to science? • Important news goes unsung • Letters to the editor • One day of blood-giving leaves campus perplexed • Ursinus grad, Lloyd Wood \u2725, is Lt. Governor • Co-eds defeated by Bryn Mawr team; Jody Woodruff elected as tennis head • Belles win opener; Spencer fans nine • F & M track team beats Bruin cindermen, 64-62 • Ursinus baseball team defeated, 6-4; Losers held to four hits by Lehigh • Cumpstone is eighth in Penn javelin throw • Drop Albright in 5-4 net upset • Curtis holds lead in League I play • Grizzlies beat F & M nine; But lose to Elizabethtown • PA. Dutch film shown • Fresh-more frolic set • French Club plans banquet • Communion breakfast planned • Pi Gamma Mu frat holds district banquet • Lit reading Tuesdayhttps://digitalcommons.ursinus.edu/weekly/1567/thumbnail.jp
Strategies to build a positive and inclusive Antarctic field work environment
To increase inclusivity, diversity, equity and accessibility in Antarctic science, we must build more positive and inclusive Antarctic field work environments. The International Thwaites Glacier Collaboration (ITGC) has engaged in efforts to contribute to that goal through a variety of activities since 2018, including creating an open-access ‘Field and Ship Best Practices’ guide, engaging in pre-field season team dynamics meetings, and surveying post-field season reflections and experiences. We report specific actions taken by ITGC and their outcomes. We found that strong and supported early career researchers brought new and important perspectives regarding strategies for transforming culture. We discovered that engaged and involved senior leadership was also critical for expanding participation and securing funding to support efforts. Pre-field discussions involving all field team members were particularly helpful for setting expectations, improving sense of belonging, describing field work best practices, and co-creating a positive work culture
A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors
A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiproliferative activities in nanomolar concentrations. Among the compounds, 2a, 2b and 2e were the most active across three cancer cell lines. In addition, these compounds inhibited the polymerisation of tubulin in vitro more efficiently than CA-4. They caused cell cycle arrest in G2/M phase further confirming their ability to inhibit tubulin polymerisation
Prisoners’ Families’ Research: Developments, Debates and Directions
After many years of relative obscurity, research on prisoners’ families has gained significant momentum. It has expanded from case-oriented descriptive analyses of family experiences to longitudinal studies of child and family development and even macro analyses of the effects on communities in societies of mass incarceration. Now the field engages multi-disciplinary and international interest although it arguably still remains on the periphery of mainstream criminological, psychological and sociological research agendas. This chapter discusses developments in prisoners’ families’ research and its positioning in academia and practice. It does not aim to provide an all-encompassing review of the literature rather it will offer some reflections on how and why the field has developed as it has and on its future directions. The chapter is divided into three parts. The first discusses reasons for the historically small body of research on prisoners’ families and for the growth in research interest over the past two decades. The second analyses patterns and shifts in the focus of research studies and considers how the field has been shaped by intersecting disciplinary interests of psychology, sociology, criminology and socio-legal studies. The final part reflects on substantive and ethical issues that are likely to shape the direction of prisoners’ families’ research in the future
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