User-centred design of flexible hypermedia for a mobile guide: Reflections on the hyperaudio experience

A user-centred design approach involves end-users from the very beginning. Considering users at the early stages compels designers to think in terms of utility and usability and helps develop the system on what is actually needed. This paper discusses the case of HyperAudio, a context-sensitive adaptive and mobile guide to museums developed in the late 90s. User requirements were collected via a survey to understand visitors’ profiles and visit styles in Natural Science museums. The knowledge acquired supported the specification of system requirements, helping defining user model, data structure and adaptive behaviour of the system. User requirements guided the design decisions on what could be implemented by using simple adaptable triggers and what instead needed more sophisticated adaptive techniques, a fundamental choice when all the computation must be done on a PDA. Graphical and interactive environments for developing and testing complex adaptive systems are discussed as a further step towards an iterative design that considers the user interaction a central point. The paper discusses how such an environment allows designers and developers to experiment with different system’s behaviours and to widely test it under realistic conditions by simulation of the actual context evolving over time. The understanding gained in HyperAudio is then considered in the perspective of the developments that followed that first experience: our findings seem still valid despite the passed time

Resolution of Corneal Fibrosis After Descemet's Stripping Automated Endothelial Keratoplasty: A Case Report.

To report the resolution of anterior corneal fibrosis after Descemet's stripping automated endothelial keratoplasty (DSAEK), in a patient with chronic corneal edema and anterior stromal scarring. A 63-year-old woman, with a history of Fuchs endothelial dystrophy, presented with increasing discomfort and gradual visual loss in her right eye. Clinical examination revealed long-standing bullous keratopathy accompanied by marked subepithelial fibrosis (SEF). Based on the low postoperative visual potential due to glaucomatous optic neuropathy, we decided to proceed with DSAEK. During the follow-up period, SEF was found to gradually resolve. Corneal clarity was restored and an improvement in visual acuity was observed up to 12 months after surgery. DSAEK alone may represent an effective therapeutic option for the restoration of impaired corneal clarity in patients with long-standing corneal edema and concomitant anterior subepithelial scarring

Cross-lingual document retrieval categorisation and navigation based on distributed services

The widespread use of the Internet across countries has increased the need for access to document collections that are often written in languages different from a user’s native language. In this paper we describe Clarity, a Cross Language Information Retrieval (CLIR) system for English, Finnish, Swedish, Latvian and Lithuanian. Clarity is a fully-fledged retrieval system that supports the user during the whole process of query formulation, text retrieval and document browsing. We address four of the major aspects of Clarity: (i) the user-driven methodology that formed the basis for the iterative design cycle and framework in the project, (ii) the system architecture that was developed to support the interaction and coordination of Clarity’s distributed services, (iii) the data resources and methods for query translation, and (iv) the support for Baltic languages. Clarity is an example of a distributed CLIR system built with minimal translation resources and, to our knowledge, the only such system that currently supports Baltic languages

Actualización en radiología dental: Radiología convencional Vs digital

Desde su incorporación a la práctica odontológica la radiología digital ha experimentado un importante desarrollo. El continuo avance de las tecnologías en las que se sustenta ha dotado a estos sistemas de interesantes prestaciones que pueden facilitar el diagnóstico y manejo de imágenes radiográficas. Con estos avances la radiología digital ha despertado un interés creciente entre los profesionales de la odontología, especialmente durante los últimos años, en los que ha aumentado notoriamente tanto la cantidad de sistemas comercializados como el número de odontólogos que han decidido sustituir la radiología convencional por un sistema digital en sus clínicas. En esta revisión de la literatura se tratará de ofrecer una visión actualizada de los distintos sistemas disponibles en la actualidad, así como una comparativa entre ellos basada en estudios publicados recientemente. Since its appearance in dentistry, digital radiology has experienced a notorious development. A constant advance in the corresponding technologies has enhanced these digital systems with interesting features which may facilitate radiological diagnosis and image management. Due to these advances digital radiology has elicited a growing interest in dentistry. Specially during the last years there has been an increase both in the amount of available systems and in the number of dentists who have incorporated a digital system in their offices. This literature review aims to offer an updated view of the available systems and a comparison of them based in recent studies

Colour-Octet Effects in Radiative Υ\Upsilon Decays

We investigate the effects of colour-octet contributions to the radiative $\Upsilon$ decay within the Bodwin, Braaten and Lepage NRQCD factorization framework. Photons coming both from the coupling to hard processes (`direct') and by collinear emission from light quarks (`fragmentation') are consistently included at next-to-leading order (NLO) in $\alpha_s$. An estimate for the non-perturbative matrix elements which enter in the final result is then obtained. By comparing the NRQCD prediction at NLO for total decay rates with the experimental data, it is found that the non-perturbative parameters must be smaller than expected from the na\"\i ve scaling rules of NRQCD. Nevertheless, colour-octet contributions to the shape of the photon spectrum turn out to be significant.Comment: 25 pages, Latex, 8 figure

Traditional Free-Ranging Livestock Farming as a Management Strategy for Biological and Cultural Landscape Diversity: A Case from the Southern Apennines

Mediterranean mountain landscapes are undergoing a widespread phenomenon of abandonment. This brings, as a consequence, the loss of traditional land use practices, such as transhumant pastoralism, as well as shrub and wood encroachment, with repercussions on the biodiversity associated with semi-open, human-managed landscapes. In this study, we focus on a mountain pasture from the Southern Apennines (Italy), where free-ranging transhumant grazing is still carried out, to quantify the effects of grazing presence and exclusion on arthropod diversity, and to qualitatively characterize the plant communities of grazed and ungrazed areas. Using field sampling, remote sensing, and semi-structured interviews, we assessed the validity of traditional cattle farming as a landscape management tool. Indeed, high diversity grasslands excluded from grazing were characterized by significantly less even and more dominated arthropod communities, as well as fewer plant species and families. Moreover, in areas that have been consistently grazed over the years, we found no forest encroachment from 1955 to 2019. However, rural communities are experiencing difficulties in keeping local traditions alive, even with current agri-environmental schemes. Thus, traditional livestock grazing can be a valuable management tool to maintain high biological and cultural diversity, even if stronger cooperation and attention to local needs is necessary

Family memories in the home: contrasting physical and digital mementos

We carried out fieldwork to characterise and compare physical and digital mementos in the home. Physical mementos are highly valued, heterogeneous and support different types of recollection. Contrary to expectations, we found physical mementos are not purely representational, and can involve appropriating common objects and more idiosyncratic forms. In contrast, digital mementos were initially perceived as less valuable, although participants later reconsidered this. Digital mementos were somewhat limited in function and expression, largely involving representational photos and videos, and infrequently accessed. We explain these digital limitations and conclude with design guidelines for digital mementos, including better techniques for accessing and integrating these into everyday life, allowing them to acquire the symbolic associations and lasting value that characterise their physical counterparts

The relationship between smoking exposure and p53 overexpression in colorectal cancer.

Although epidemiological studies of the relationship between cigarette smoking and colorectal cancer risk have been equivocal, a positive association is consistently found for colorectal adenoma development. We performed an epidemiological study to determine whether p53 protein overexpression, in tumours obtained at the time of resection, is associated with cigarette exposure in colorectal cancer. A total of 163 colorectal cancer cases and 326 healthy controls responded to a standardised questionnaire on colorectal cancer risk factors including detailed information on their history of cigarette smoking. All patients' tumours were analysed immunohistochemically for p53 overexpression using an avidin-biotin immunoperoxidase procedure and polyclonal anti-p53 antibody CM1. Comparison of colorectal cases with controls revealed an elevated risk for ex-smokers (OR = 1.34, 95% CI 0.85-2.12) and current smokers (OR = 1.13, 95% CI 0.63-2.02) when compared with non-smokers. No dose-response relationship was found for total pack-years of smoking (trend test: P = 0.19). However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). Estimating the individual relative risk of developing a p53-positive tumour relative to controls showed no associations for smoking status or total pack-years of smoking. However, when p53-negative cases were compared with controls, an elevated risk was found for ex-smokers (OR = 1.84, 95% CI 1.00-3.37) and current years of smoking (trend test: P = 0.03). Colorectal tumours developing through p53-positive dependent pathways were not associated with smoking exposure. A significant increase in risk was observed for the p53-negative independent pathway with smoking. p53 overexpression appears to be associated with smoking exposure in colorectal cancer

QCD analysis of inclusive B decay into charmonium

We compute the decay rates and $H$-energy distributions of $B$ mesons into the final state $H+X$, where $H$ can be any one of the $S$-wave or $P$-wave charmonia, at next-to-leading order in the strong coupling. We find that a significant fraction of the observed $J/\psi$, $\psi'$ and $\chi_c$ must be produced through $c\bar{c}$ pairs in a colour octet state and should therefore be accompanied by more than one light hadron. At the same time we obtain stringent constraints on some of the long-distance parameters for colour octet production.Comment: 40 pages, RevTeX, 4 figure