Cover Crop for a Sustainable Viticulture: Effects on Soil Properties and Table Grape Production

Cover crops are increasingly adopted in viticulture to enhance soil quality and balance the vegetative and reproductive growth of vines. Nevertheless, this sustainable practice has been only recently used for table grape viticulture, with results often contrasting. The aim of this study was to assess the effect of a fescue (Festucaarundinacea Schreb.) cover crop on soil quality, yield, and grape qualitative parameters in a table grape vineyard (cv "Italia") located in southern Italy, comparing results with the conventional tillage. Soil organic carbon (C), total nitrogen (N), microbial biomass C (MBC), β-glucosidase (BGLU) and alkaline phosphomonoesterase (APME) activities were assessed during three growing seasons (2012–2014) and three phenological stages. The trend of soil chemical and microbiological properties was jointly influenced by the soil management system, growing season and phenological stage. Compared to conventional tillage, cover crops increased, on average, soil organic C, total N, MBC, BGLU and APME by 136%, 93%, 112%, 100% and 62%, respectively. Slight or no effects of cover crops were observed on grape quality and yield, except for 2012 (the driest season), when a yield reduction occurred. This study reveals that cover crops strongly enhance soil quality in the short-term, with potential advantages for grape production in the long-term

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression

Autoimmune type 1 diabetes (T1D) is thought to be caused by a defective immune regulation with regulatory T (Treg) cells playing a fundamental role in this process. Tolerance mechanisms depend on tunable responses that are sensitive to minor perturbations in the expression of molecules that can be carried out by multiple epigenetic mechanisms, including regulation by microRNAs. In this study, microRNA expression profile was investigated in Treg cells isolated from peripheral blood (PB) and from pancreatic draining lymph nodes (PLN) of T1D patients and non-diabetic subjects. Among 72 microRNAs analyzed, miR-125a-5p resulted specifically hyper-expressed in Treg cells purified from PLN of T1D patients. TNFR2 and CCR2 were identified as miR-125a-5p target genes. Elevated miR-125a-5p was detected in Treg cells isolated from PLN but not from PB of donors with T1D and was associated with reduced CCR2 expression. A specific beta-cell expression of the CCR2-ligand (CCL2) was observed in the pancreata of cadaveric donors, suggesting that beta-cells are prone to attract CCR2+ Treg cells. These novel data propose a mechanism, occurring in PLNs of T1D patients, involving increased expression of miR-125a-5p on Treg cells which results into reduced expression of CCR2, thus limiting their migration and eventual function in the pancreas

Prevalence of hepatic steatosis in patients with type 2 diabetes and response to glucose-lowering treatments. A multicenter retrospective study in Italian specialist care

Type 2 diabetes (T2D) is a risk factor for metabolic dysfunction-associated fatty liver disease (MAFLD), which is becoming the commonest cause of chronic liver disease worldwide. We estimated MAFLD prevalence among patients with T2D using the hepatic steatosis index (HSI) and validated it against liver ultrasound. We also examined whether glucose-lowering medications (GLM) beneficially affected HSI

Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study

Aims According to cardiovascular outcome trials, some sodium-glucose contransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real-world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP-1RA as second or a more advanced line of therapy. Materials and methods DARWIN-T2D was a retrospective multi-centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP-1RA (exenatide once weekly or liraglutide). Data were collected at baseline and at the first follow-up visit after 3 to 12 months. The primary endpoint was the proportion of patients achieving a simultaneous reduction in HbA1c, body weight and systolic blood pressure. To reduce confounding, we used multivariable adjustment (MVA) or propensity score matching (PSM). Results Totals of 473 patients initiating dapagliflozin and 336 patients initiating GLP-1RA were included. The two groups differed in age, diabetes duration, HbA1c, weight and concomitant medications. The median follow-up was 6 months in both groups. Using MVA or PSM, the primary endpoint was observed in 30% to 32% of patients, with no difference between groups. Simultaneous reduction of HbA1c, BP and SBP by specific threshold, as well as achievement of final goals, did not differ between groups. GLP-1RA reduced HbA1c by 0.3% more than the reduction achieved with dapagliflozin. Conclusion In routine specialist care, initiation of dapagliflozin can be as effective as initiation of a GLP-1RA for attainment of combined risk factor goals

SINTOMI PSICOLOGICI E QUALITA’ DELLA VITA NELLA POPOLAZIONE DI L’AQUILA DOPO IL TERREMOTO DEL 2009

Introduzione: A seguito del terremoto di L’Aquila del 6.4.2009 più di 65000 persone hanno dovuto abbandonare le proprie abitazioni. Allo scopo di fornire rapida sistemazione a coloro che avevano perso la casa, è stato varato il progetto C.A.S.E (Complessi Antisismici Sostenibili Ecocompatibili), con la costruzione di 19 “New town” nelle zone limitrofe della città, strutture isolate dal contesto urbano, prive di servizi e centri di aggregazione. L’assegnazione degli appartamenti è stata effettuata tenendo conto del numero dei membri della famiglia, della presenza di disabilità, escludendo di valutare esigenze affettive o familiari. Lo scopo del presente studio è stato quello di valutare la prevalenza di disordini mentali, dei livelli di sintomi psicologici e della qualità della vita in un campione di popolazione che vive in tali realtà. Metodi: Le scale “Brief Symptom Inventory” (BSI) e “Impact of Events Scale-Revised” (IES-R) sono state utilizzate per valutare i sintomi psicologici; la qualità soggettiva della vita è stata valutata usando la scala MANSA (Manchester Short Assessment of Quality of Life). Risultati: Sono state intervistate 107 persone tra marzo e agosto 2011. Il punteggio medio della scala BSI è risultato di 0,7; il cut-off di 33 della scala IES-R è stato superato da circa il 60% del campione (valore medio 38); il punteggio medio ottenuto con la scala MANSA è stato di 4,5. Tali risultati mostrano una elevata prevalenza di disordini mentali e un elevato livello di sintomi, mentre la qualità della vita si attesta su un livello “neutro”. Le persone si sentono sicure, ma non considerano soddisfacente la situazione abitativa in quanto percepiscono di aver perso identità sociale e spirito di comunità. Conclusioni: Dai risultati sembra emergere, pertanto, che tale soluzione abitativa potrebbe rappresentare un ulteriore elemento di trauma che si sovrappone a quello sofferto nel periodo del terremoto

Psychological symptoms and quality of life in a population living in the "New Towns" of L'Aquila after he 2009 earthquake

Background: Following the earthquake in L'Aquila of 04.06.2009 more than 65,000 people lost their homes. In order to provide rapid accommodation to those people, the Italian Government implemented the CASE project (Complex Anti-seismic Sustainable Environment-friendly), with the construction of 19 "New town" in the surrounding areas of the city. The New towns are built in rural areas, far from the center of the city, without  many basic services. The purpose of this study was to evaluate the prevalence of mental disorders, the levels of psychological symptoms and quality of life in a sample of the population living in such reality. Methods: Brief Symptom Inventory (BSI), the Impact of Events Scale-Revised (IES-R), and the Manchester Short Assessment of Quality of Life (MANSA), were used. Results: 107 people were interviewed. The mean scores of the GSI of the BSI were 0.70 (SD=0.55). The total score of the IES-R scale was used and the cut-off represented by the 33 value, was exceeded by 59.81% of the sample. The average value was 37.85 (SD=19.49) (range 0-83). 14 people of them (21.88%) obtained an average value ≥ 60. The mean score on the MANSA was 4.5 (SD=0.98), range 1.8-6.3. Conclusion: From the results, it appears that this housing solution could be an additional element of trauma that overlaps with that suffered during the quake

PSYCHOLOGICAL SYMPTOMS AND QUALITY OF LIFE IN A POPULATION LIVING IN THE "NEW TOWNS" OF L'AQUILA AFTER THE 2009 EARTHQUAKE

Background: Following the earthquake in L'Aquila of 04.06.2009 more than 65,000 people lost their homes. In order to provide rapid accommodation to those people, the Italian Government implemented the CASE project (Complex Anti-seismic Sustainable Environment-friendly), with the construction of 19 "New town" in the surrounding areas of the city. The New towns are built in rural areas, far from the center of the city, without  many basic services. The purpose of this study was to evaluate the prevalence of mental disorders, the levels of psychological symptoms and quality of life in a sample of the population living in such reality. Methods: Brief Symptom Inventory (BSI), the Impact of Events Scale-Revised (IES-R), and the Manchester Short Assessment of Quality of Life (MANSA), were used. Results: 107 people were interviewed. The mean scores of the GSI of the BSI were 0.70 (SD=0.55). The total score of the IES-R scale was used and the cut-off represented by the 33 value, was exceeded by 59.81% of the sample. The average value was 37.85 (SD=19.49) (range 0-83). 14 people of them (21.88%) obtained an average value ≥ 60. The mean score on the MANSA was 4.5 (SD=0.98), range 1.8-6.3. Conclusion: From the results, it appears that this housing solution could be an additional element of trauma that overlaps with that suffered during the quake

Psychological symptoms and quality of life after repeated exposure to earthquake: A cohort study in Italy.

In 2005, a random sample of 200 people were assessed in Camerino, Italy, eight years after an earthquake. Psychological symptom levels were low and only one person had current Post-Traumatic Stress Disorder (PTSD). In 2016 a new earthquake occurred in Camerino. The study aims to assess the impact of the second exposure in the same cohort. A longitudinal study was conducted, 130 participants were re-interviewed between July and December 2017. Psychological symptoms were self-rated on the Brief Symptom Inventory (BSI) and the Global Severity Index (GSI) was analysed. Post-traumatic stress symptoms were self-rated on the Impact of Event Scale-Revised (IES-R). Subjective quality of life (SQOL) was assessed on the Manchester Short Assessment of Quality of Life (MANSA). Mean scores of GSI and IES-R were significantly higher than in 2005 (p<0.01 and p<0.001), whilst SQOL remained almost unchanged (p = 0.163). In 2017, 16.9% of the sample had reached the PTSD threshold whilst in 2005 only the 0.5% had reached it. Despite low symptom levels several years after an earthquake, people can show psychological distress after a new exposure, whilst average quality of life levels are not affected

Cover Crop for a Sustainable Viticulture: Effects on Soil Properties and Table Grape Production

Cover crops are increasingly adopted in viticulture to enhance soil quality and balance the vegetative and reproductive growth of vines. Nevertheless, this sustainable practice has been only recently used for table grape viticulture, with results often contrasting. The aim of this study was to assess the effect of a fescue (Festucaarundinacea Schreb.) cover crop on soil quality, yield, and grape qualitative parameters in a table grape vineyard (cv &ldquo;Italia&rdquo;) located in southern Italy, comparing results with the conventional tillage. Soil organic carbon (C), total nitrogen (N), microbial biomass C (MBC), &beta;-glucosidase (BGLU) and alkaline phosphomonoesterase (APME) activities were assessed during three growing seasons (2012&ndash;2014) and three phenological stages. The trend of soil chemical and microbiological properties was jointly influenced by the soil management system, growing season and phenological stage. Compared to conventional tillage, cover crops increased, on average, soil organic C, total N, MBC, BGLU and APME by 136%, 93%, 112%, 100% and 62%, respectively. Slight or no effects of cover crops were observed on grape quality and yield, except for 2012 (the driest season), when a yield reduction occurred. This study reveals that cover crops strongly enhance soil quality in the short-term, with potential advantages for grape production in the long-term

Allergic Reactions to COVID-19 Vaccines: Risk Factors, Frequency, Mechanisms and Management

Conventional vaccines have been widely studied, along with their risk of causing allergic reactions. These generally consist of mild local reactions and only rarely severe anaphylaxis. Although all the current COVID-19 vaccines marketed in Europe have been shown to be safe overall in the general population, early post-marketing evidence has shown that mRNA-based vaccines using novel platforms (i.e., lipid nanoparticles) were associated with an increased risk of severe allergic reactions as compared to conventional vaccines. In this paper we performed an updated literature review on frequency, risk factors, and underlying mechanisms of COVID-19 vaccine-related allergies by searching MEDLINE and Google Scholar databases. We also conducted a qualitative search on VigiBase and EudraVigilance databases to identify reports of "Hypersensitivity" and "Anaphylactic reaction" potentially related to COVID-19 vaccines (Comirnaty, Spikevax, Vaxzevria and COVID-19 Janssen Vaccine), and in EudraVigilance to estimate the reporting rates of "Anaphylactic reaction" and "Anaphylactic shock" after COVID-19 vaccination in the&nbsp;European population. We also summarized the scientific societies' and regulatory agencies' recommendations for prevention and management of COVID-19 vaccine-related allergic reactions, especially in those with a history of allergy