4,387 research outputs found
Reengineering Undergraduate Teaching by Introducing Internet Based Learning Information Systems
This paper illustrates how internet-based learning information systems can be used to reengineer undergraduate teaching in the age of mass higher education. We describe current problems of undergraduate teaching by using an example of an introductory course in information technology at the Vienna University of Economics and Business Administration. We argue that an internet-based learning information system supports specialisation, quality assurance and knowledge management. This paper also shows how internet-based learning information systems in combination with a re-organised teaching process leads to a more effective organisation. Obstacles to reengineering undergraduate teaching resulting from the legal framework are examined
Rule of law infringement procedures: A proposal to extend the EUâs rule of law toolbox. CEPS Paper on Liberty and Security in Europe, No. 2019-09, May 2019
In this contribution, we propose that the Court of Justice of the European Union (CJEU) introduce ârule of law infringement proceduresâ, having both a fast-track and a freezing component, as part of a wider âEU rule of law toolboxâ. We show rule of law infringement proceduresâ great potential in tackling rule of law backsliding in the Member States, provided that the following rules are applied. First, the European Commission should identify the rule of law problem explicitly. Second, it should not waste time and postpone its legal actions, while a Member State openly violates the rule of law. Third, the CJEU should automatically prioritise and accelerate infringement cases with a rule of law element to avoid more harm being done by those in power. Fourth, interim measures should be used to put an immediate halt to rule of law violations that can culminate in grave and irreversible harm. Fifth, EU institutions should establish a periodic rule of law review. It should help them to determine if there is a systemic threat to the rule of law in a given Member State, and provide additional legitimacy to the European Commission for initiating rule of law infringement actions and to the CJEU for ruling on such matters
Commentary: Musicians' online performance during auditory and visual statistical learning tasks
A commentary on: Musicians' Online Performance during Auditory and Visual Statistical Learning Tasks
by Mandikal Vasuki, P. R., Sharma, M., Ibrahim, R. K., and Arciuli, J. (2017). Front. Hum. Neurosci. 11:114. doi: 10.3389/fnhum.2017.00114
Statistical learning (SL) is the extraction of the underlying statistical structure from sensory input (Frost et al., 2015). The extent to which this ability is domain-general (with a single central mechanism underpinning SL in any modality) or domain-specific (where the SL mechanism differs by modality) remains a central question in statistical learning (Frost et al., 2015), and two approaches have been adopted to tackle this. First is to examine the extent to which predominantly domain-specific skills such as language proficiency (Arciuli and von Koss Torkildsen, 2012) and musical expertise (Schön and François, 2011), and domain-general skills such as working memory and general IQ (Siegelman and Frost, 2015), correlate with SL ability. Second is to compare SL performance across modalities, or even examine cross-modal transfer (Durrant et al., 2016).
Mandikal Vasuki et al. (2017) (and the sister paper: Mandikal Vasuki et al., 2016) make an important contribution by adopting both of these approaches. They compare auditory and visual SL using the Saffran triplet learning paradigm (Saffran et al., 1999) in musicians and non-musicians. The three key findings are that musicians are better than non-musicians at segmentation of auditory stimuli only, there is no correlation between auditory and visual performance, and that auditory performance is better overall. This last result could be due to privileged auditory processing of sequential stimuli (Conway et al., 2009), or it could just reflect differences in perceptual or memory capabilities across modalities. However, the fact that SL performance in one modality does not predict performance in another is hard to explain if a single mechanism underlying both is posited. Combined with the fact that overall better performance was found in musicians only in the auditory modality, a domain-specific SL mechanism seems to offer the most parsimonious explanation of this data
Putting Cells into Context
Opinion article (excerpt): Cells Live in a Complex World It may sound
blatantly obvious, but we have to remind ourselves occasionally that in vivo
cells experience an environment with a level of complexity far beyond
experimental reach. The developing organism is a highly complex system, where
each cell receives a multitude of cues of diverse nature at any given time
point. Only the comprehensive integration of all these multivalent
interactions determines the actual signaling state and hence the behavior of a
cell. The analysis of biological questions is mainly inspired by a
reductionist approach adopted from the âexact sciences,â where it has been
proven immensely successful. That is, we are used to break down our
experimental setup to a manageable number of variables. This of course is
inherently contradictory to the complexity of biological systems. While
simplification may be the only viable option for the experimenter to dissect
biological function down to detail, it has also influenced our perspective
toward the experimental systems applied. For example, studies of intracellular
signaling pathways are typically performed with cultured cells. Culturing
cells in an in vitro setting became a standard model system in biomedical
research and with it in cell and developmental biology. These simplified
systems allow for the dissection of molecular interactions and pathways and
are aimed to deepen and mechanistically understand cellular behavior. While
cell cultures have generated a wealth of information into cellular function,
the data obtained in vitro frequently are in conflict with in vivo
observations. One reason for this discrepancy is that these analyses focus on
the cell as a closed functional system, thus conceptually unhinging it from
its environment
Low-energy house in Sisimiut:Annual report of Low-energy house performance July 2008 to June 2009
N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana
Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in genome annotations. We constructed a proteogenomic pipeline specific for the analysis of N-terminal proteomics data, with the aim of discovering novel translational start sites outside annotated protein coding regions. In summary, unidentified MS/MS spectra were matched to a specific N-terminal peptide library encompassing protein N termini encoded in the Arabidopsis thaliana genome. After a stringent false discovery rate filtering, 117 protein N termini compliant with N-terminal methionine excision specificity and indicative of translation initiation were found. These include N-terminal protein extensions and translation from transposable elements and pseudogenes. Gene prediction provided supporting protein-coding models for approximately half of the protein N termini. Besides the prediction of functional domains (partially) contained within the newly predicted ORFs, further supporting evidence of translation was found in the recently released Araport11 genome re-annotation of Arabidopsis and computational translations of sequences stored in public repositories. Most interestingly, complementary evidence by ribosome profiling was found for 23 protein N termini. Finally, by analyzing protein N-terminal peptides, an in silico analysis demonstrates the applicability of our N-terminal proteogenomics strategy in revealing protein-coding potential in species with well-and poorly-annotated genomes
Resonance graphs of plane bipartite graphs as daisy cubes
We characterize all plane bipartite graphs whose resonance graphs are daisy
cubes and therefore generalize related results on resonance graphs of benzenoid
graphs, catacondensed even ring systems, as well as 2-connected outerplane
bipartite graphs. Firstly, we prove that if is a plane elementary bipartite
graph other than , then the resonance graph is a daisy cube if and
only if the Fries number of equals the number of finite faces of , which
in turn is equivalent to being homeomorphically peripheral color
alternating. Next, we extend the above characterization from plane elementary
bipartite graphs to all plane bipartite graphs and show that the resonance
graph of a plane bipartite graph is a daisy cube if and only if is
weakly elementary bipartite and every elementary component of other than
is homeomorphically peripheral color alternating. Along the way, we prove
that a Cartesian product graph is a daisy cube if and only if all of its
nontrivial factors are daisy cubes
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