86 research outputs found

    Esterilización parcial del suelo para el cultivo en invernáculo

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    Traducción de los profesores de la Facultad Ingenieros AgrónomosFacultad de Ciencias Agrarias y Forestale

    Esterilización parcial del suelo para el cultivo en invernáculo

    Get PDF
    Traducción de los profesores de la Facultad Ingenieros AgrónomosFacultad de Ciencias Agrarias y Forestale

    Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas

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    Notwithstanding the well-characterised roles of a number of oncogenes in neoplastic transformation, microRNAs (miRNAs) are increasingly implicated in several human cancers. Discovery of miRNAs in several oncogenic herpesviruses such as KSHV has further highlighted the potential of virus-encoded miRNAs to contribute to their oncogenic capabilities. Nevertheless, despite the identification of several possible cancer-related genes as their targets, the direct in vivo role of virus-encoded miRNAs in neoplastic diseases such as those induced by KSHV is difficult to demonstrate in the absence of suitable models. However, excellent natural disease models of rapid-onset Marek's disease (MD) lymphomas in chickens allow examination of the oncogenic potential of virus-encoded miRNAs. Using viruses modified by reverse genetics of the infectious BAC clone of the oncogenic RB-1B strain of MDV, we show that the deletion of the six-miRNA cluster 1 from the viral genome abolished the oncogenicity of the virus. This loss of oncogenicity appeared to be primarily due to the single miRNA within the cluster, miR-M4, the ortholog of cellular miR-155, since its deletion or a 2-nucleotide mutation within its seed region was sufficient to inhibit the induction of lymphomas. The definitive role of this miR-155 ortholog in oncogenicity was further confirmed by the rescue of oncogenic phenotype by revertant viruses that expressed either the miR-M4 or the cellular homolog gga-miR-155. This is the first demonstration of the direct in vivo role of a virus-encoded miRNA in inducing tumors in a natural infection model. Furthermore, the use of viruses deleted in miRNAs as effective vaccines against virulent MDV challenge, enables the prospects of generating genetically defined attenuated vaccines

    Some cultural consequences in Spain of the Spanish Invasion of Morocco 1859-60

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    This article argues is a contribution to the study of interrelationships between colonialism, art, and literature in the nineteenth century. The article argues that the Spanish invasion of Morocco in 1859 led to contradictions and tensions within liberal nationalism, not least because of concerns about the tensions between the need for military reassertion of Spain and the respect for the independence of nations. This led to some reconfiguration of Spanish intellectuals' already complex relationship with North Africa and Islam. A major, perhaps surprising consequence of this reconfiguration, was some equation of Moroccan identity with a monotonous surface that was resistant to the gaze. In consequence, the Catalan painter Fortuny's crucial experience of Morocco led him to value near blank surfaces, and thus to make a major contribution to the origins of modern art

    Different expressions of the same mode: a recent dialogue between archaeological and contemporary drawing practices

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    In this article we explore what we perceive as pertinent features of shared experience at the excavations of an Iron Age Hillfort at Bodfari, North Wales, referencing artist, archaeologist and examples of seminal art works and archaeological records resulting through inter-disciplinary collaboration. We explore ways along which archaeological and artistic practices of improvisation become entangled and productive through their different modes of mark-making. We contend that marks and memories of artist and archaeologist alike emerge interactively, through the mutually constituting effects of the object of study, the tools of exploration, and the practitioners themselves, when they are enmeshed in the cross-modally bound activities. These include, but are not limited to, remote sensing, surveying, mattocking, trowelling, drawing, photographing, videoing and sound recording. These marks represent the co-signatories: the gesture of the often anonymous practitioners, the voice of the deposits, as well as the imprint of the tools, and their interplay creates a multi-threaded narrative documenting their modes of intra-action, in short our practices. They occupy the conceptual space of paradata, and in the process of saturating the interstices of digital cognitive prosthetics they lend probity to their translations in both art form and archive

    Post-identity politics and the social weightlessness of radical gender theory

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    This paper analysis current forms of post-identity politics within contemporary gender theory, notably the works of Rosi Braidotti, Elizabeth Grosz and Bobby Noble. Although these thinkers offer some important insights, I argue that their theories ultimately suffer from what Lois McNay has labelled ‘social weightlessness’. This is because their models of subjectivity and agency are severed from the everyday realities of social subjects. I indicate two ways that this social weightlessness is manifested in radical gender theories which offer a post-identity politics: (1) they underappreciate the social and political importance to many people of establishing stable, coherent identities; (ii) they are unable to offer a satisfactory account of agency. I suggest that these issues result, at least partly, from the anti-recognition stance adopted by these theorists. By incorporating an adequate model of recognition back into their theories, I claim, will equip their accounts with a properly-grounded model of the subject, which is responsive to the inequalities and oppressions that infuse the particular concrete contexts in which we experience and live out our identities
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