887 research outputs found
A Detailed Monte-Carlo Simulation for the Belle TOF System
We have developed a detailed Monte Carlo simulation program for the Belle TOF
system. Based on GEANT simulation, it takes account of all physics processes in
the TOF scintillation counters and readout electronics. The simulation
reproduces very well the performance of the Belle TOF system, including the
dE/dx response, the time walk effect, the time resolution, and the hit
efficiency due to beam background. In this report, we will describe the Belle
TOF simulation program in detail.Comment: To be submitted to NI
Photoproduction of mesons in nuclei at GeV energies
In a transport model that combines initial state interactions of the photon
with final state interactions of the produced particles we present a
calculation of inclusive photoproduction of mesons in nuclei in the energy
range from 1 to 7 GeV. We give predictions for the photoproduction cross
sections of pions, etas, kaons, antikaons, and invariant mass
spectra in ^{12}C and ^{208}Pb. The effects of nuclear shadowing and final
state interaction of the produced particles are discussed in detail.Comment: Text added in summary in general reliability of the method,
references updated. Phys. Rev. C (2000) in pres
Riempjes (Corrigiola litoralis L.) terug in het rivierengebied
Riempjes lijkt definitief terug in het Nederlandse rivierengebied. Vanaf de eerste waarnemingen in 1996 is zowel het aantal groeiplaatsen als het aantal exemplaren langs de Waal in de omgeving van Nijmegen gestaag toegenomen, met als belangrijkste standplaatsen: de Gendtse Polder, de Bizonbaai (Ooijpolder) en de Oosterhoutsche Waar
Reanalysis of two eclipsing binaries: EE Aqr and Z Vul
We study the radial-velocity and light curves of the two eclipsing binaries
EE Aqr and Z Vul. Using the latest version of the Wilson & Van Hamme (2003)
model, absolute parameters for the systems are determined. We find that EE Aqr
and Z Vul are near-contact and semi-detached systems, respectively. The primary
component of EE Aqr fills about 96% of its 'Roche lobe', while its secondary
one appears close to completely filling this limiting volume. In a similar way,
we find fill-out proportions of about 72 and 100% of these volumes for the
primary and secondary components of Z Vul respectively. We compare our results
with those of previous authors.Comment: 13 pages, 8 figures, 10 table
In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease
Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that progressively lead to kidney failure. The currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative treatments. The signaling rewiring in PKD that drives cyst formation is highly complex and not fully understood. As a consequence, the effects of drugs are sometimes difficult to predict. We previously established a high throughput microscopy phenotypic screening method for quantitative assessment of renal cyst growth. Here, we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules, including approved drugs. We identified 81 active molecules that inhibit cyst growth. Multi-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological properties. Celastrol, a triterpenoid from Tripterygium Wilfordii, was identified as a potent inhibitor of cyst growth in vitro. In an in vivo iKspCre-Pkd1lox,lox mouse model for PKD, celastrol inhibited the growth of renal cysts and maintained kidney function.Medicinal Chemistr
Interstellar MHD Turbulence and Star Formation
This chapter reviews the nature of turbulence in the Galactic interstellar
medium (ISM) and its connections to the star formation (SF) process. The ISM is
turbulent, magnetized, self-gravitating, and is subject to heating and cooling
processes that control its thermodynamic behavior. The turbulence in the warm
and hot ionized components of the ISM appears to be trans- or subsonic, and
thus to behave nearly incompressibly. However, the neutral warm and cold
components are highly compressible, as a consequence of both thermal
instability in the atomic gas and of moderately-to-strongly supersonic motions
in the roughly isothermal cold atomic and molecular components. Within this
context, we discuss: i) the production and statistical distribution of
turbulent density fluctuations in both isothermal and polytropic media; ii) the
nature of the clumps produced by thermal instability, noting that, contrary to
classical ideas, they in general accrete mass from their environment; iii) the
density-magnetic field correlation (or lack thereof) in turbulent density
fluctuations, as a consequence of the superposition of the different wave modes
in the turbulent flow; iv) the evolution of the mass-to-magnetic flux ratio
(MFR) in density fluctuations as they are built up by dynamic compressions; v)
the formation of cold, dense clouds aided by thermal instability; vi) the
expectation that star-forming molecular clouds are likely to be undergoing
global gravitational contraction, rather than being near equilibrium, and vii)
the regulation of the star formation rate (SFR) in such gravitationally
contracting clouds by stellar feedback which, rather than keeping the clouds
from collapsing, evaporates and diperses them while they collapse.Comment: 43 pages. Invited chapter for the book "Magnetic Fields in Diffuse
Media", edited by Elisabete de Gouveia dal Pino and Alex Lazarian. Revised as
per referee's recommendation
Measurement of the Branching Fraction for B->eta' K and Search for B->eta'pi+
We report measurements for two-body charmless B decays with an eta' meson in
the final state. Using 11.1X10^6 BBbar pairs collected with the Belle detector,
we find BF(B^+ ->eta'K^+)=(79^+12_-11 +-9)x10^-6 and BF(B^0 ->
eta'K^0)=(55^+19_-16 +-8)x10^-6, where the first and second errors are
statistical and systematic, respectively. No signal is observed in the mode B^+
-> eta' pi^+, and we set a 90% confidence level upper limit of BF(B^+->
eta'pi^+) eta'K^+- decays is
investigated and a limit at 90% confidence level of -0.20<Acp<0.32 is obtained.Comment: Submitted to Physics Letters
Observation of Cabibbo-suppressed and W-exchange Lambda_c^+ baryon decays
We present measurements of the Cabibbo-suppressed decays Lambda_c^+ -->
Lambda0 K+ and Lambda_c^+ --> Sigma0 K+ (both first observations), Lambda_c^+
--> Sigma+ K+ pi- (seen with large statistics for the first time), Lambda_c^+
--> p K+ K- and Lambda_c^+ --> p phi (measured with improved accuracy).
Improved branching ratio measurements for the decays Lambda_c^+ --> Sigma+ K+
K- and Lambda_c^+ --> Sigma+ phi, which are attributed to W-exchange diagrams,
are shown. We also present the first evidence for Lambda_c^+ --> Xi(1690)^0 K+
and set an upper limit on the non-resonant decay Lambda_c^+ --> Sigma+ K+ K-.
This analysis was performed using 32.6 fb^{-1} of data collected by the Belle
detector at the asymmetric e+ e- collider KEKB.Comment: Submitted to Phys. Lett. B. v2: A small correction to the Authorlist
was made. An earlier version of this analysis was released as
BELLE-CONF-0130, hep-ex/010800
Measurement of the inclusive semileptonic branching fraction of B mesons and |Vcb|
We present a measurement of the electron spectrum from inclusive semileptonic
{\it B} decay, using 5.1 fb of data collected with the
Belle detector. A high-momentum lepton tag was used to separate the
semileptonic {\it B} decay electrons from secondary decay electrons. We
obtained the branching fraction, , with minimal model dependence.
From this measurement, we derive a value for the Cabibbo-Kobayashi-Maskawa
matrix element .Comment: 16 pages, 3 figures, 3 table
Determination of |Vcb| using the semileptonic decay \bar{B}^0 --> D^{*+}e^-\bar{\nu}
We present a measurement of the Cabibbo-Kobayashi-Maskawa (CKM) matrix
element |Vcb| using a 10.2 fb^{-1} data sample recorded at the \Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric e^+e^- storage ring.
By extrapolating the differential decay width of the \bar{B}^0 -->
D^{*+}e^-\bar{\nu} decay to the kinematic limit at which the D^{*+} is at rest
with respect to the \bar{B}^0, we extract the product of |Vcb| with the
normalization of the decay form factor F(1), |Vcb |F(1)=
(3.54+/-0.19+/-0.18)x10^{-2}, where the first error is statistical and the
second is systematic. A value of |Vcb| = (3.88+/-0.21+/-0.20+/-0.19)x10^{-2} is
obtained using a theoretical calculation of F(1), where the third error is due
to the theoretical uncertainty in the value of F(1). The branching fraction
B(\bar{B}^0 --> D^{*+}e^-\bar{\nu}) is measured to be
(4.59+/-0.23+/-0.40)x10^{-2}.Comment: 20 pages, 6 figures, elsart.cls, submitted to PL
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