A hybrid job-shop scheduling system

The intention of the scheduling system developed at the Fraunhofer-Institute for Material Flow and Logistics is the support of a scheduler working in a job-shop. Due to the existing requirements for a job-shop scheduling system the usage of flexible knowledge representation and processing techniques is necessary. Within this system the attempt was made to combine the advantages of symbolic AI-techniques with those of neural networks

Wavefunction extended Lagrangian Born-Oppenheimer molecular dynamics

Extended Lagrangian Born-Oppenheimer molecular dynamics [Niklasson, Phys. Rev. Lett. 100 123004 (2008)] has been generalized to the propagation of the electronic wavefunctions. The technique allows highly efficient first principles molecular dynamics simulations using plane wave pseudopotential electronic structure methods that are stable and energy conserving also under incomplete and approximate self-consistency convergence. An implementation of the method within the planewave basis set is presented and the accuracy and efficiency is demonstrated both for semi-conductor and metallic materials.Comment: 6 pages, 3 figure

Thymoma and Thymic Carcinoma: Molecular Pathology and Targeted Therapy

Abstract:Thymomas and thymic carcinomas (TC) are rare epithelial tumors of the thymus. Although most thymomas have organotypic features (i.e., resemble the normal thymus), TC are morphologically undistinguishable from carcinomas in other organs. Apart from their different morphology, TC and thymomas differ also in functional terms (TC, in contrast to thymomas, have lost the capacity to promote the maturation of intratumorous lymphocytes), have different genetic features (discussed in this review), a different immunoprofile (most TC overexpress c-KIT, whereas thymomas are consistently negative), and different clinical features (TC, in contrast to thymomas, are not associated with paraneoplastic myasthenia gravis). Thus, although all the data suggest that the biology of thymomas and TC is different, in clinical practice, their therapeutic management up to now is identical. In the age of personalized medicine, the time may have come to think this over. We will briefly review the molecular genetics of malignant thymic tumors, summarize the current status of targeted therapies with an emphasis on the multitargeted kinase inhibitors sunitinib and sorafenib, and try to outline some future directions

Dependence of the density of states outer measure on the potential for deterministic Schr\"odinger operators on graphs with applications to ergodic and random models

We continue our study of the dependence of the density of states measure and related spectral functions of Schr\"odinger operators on the potential. Whereas our earlier work focused on random Schr\"odinger operators, we extend these results to Schr\"odinger operators on infinite graphs with deterministic potentials and ergodic potentials, and improve our results for random potentials. In particular, we prove the Lipschitz continuity of the DOSm for random Schr\"odinger operators on the lattice, recovering results of \cite{kachkovskiy, shamis}. For our treatment of deterministic potentials, we first study the density of states outer measure (DOSoM), defined for all Schr\"odinger operators, and prove a deterministic result of the modulus of continuity of the DOSoM with respect to the potential. We apply these results to Schr\"odinger operators on the lattice $Z^d$ and the Bethe lattice. In the former case, we prove the Lipschitz continuity of the DOSoM, and in the latter case, we prove that the DOSoM is $\frac{1}{2}$-log-H\"older continuous. Our technique combines the abstract Lipschitz property of one-parameter families of self-adjoint operators with a new finite-range reduction that allows us to study the dependency of the DOSoM and related functions on only finitely-many variables and captures the geometry of the graph at infinity.Comment: Related to arXiv:1804.02444 and arXiv:1904.01118 by the authors; New appendices C and D are added and typos corrected. Appendix C discusses inequalities between the metric of weak convergence of measures and the Kantorovich-Rubinstein-Wasserstein metric. Appendix D presents results on continuity of the Hausdorff distance between two spectra with respect to the potential

Інвестування. Методичні рекомендації до виконання розрахункових індивідуальних завдань для студентів освітньо-професійної програми підготовки бакалаврів галузі знань 0305 Економіка і підприємництво

Методичні матеріали призначено для самостійної роботи студентів галузі знань 0305 Економіка і підприємництво за всіма напрямами підготовки для виконання індивідуального розрахункового завдання з дисципліни «Інвестування». Подано рекомендації до розв’язку задач з оцінки ефективності реальних інвестиційних проектів, доходності та ризику як окремих цінних паперів, так і портфелю ЦП, визначення вартості і доходності фінансових інструментів, вибору найкращого варіанта вкладання коштів. Наведено критерії оцінювання виконання практичних завдань. Орієнтовано на активізацію виконавчого етапу навчальної діяльності студентів