Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases

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Un jeu dont vous êtes le héros : «Entre idéal et réalité : en Jeu(x) éthique(s) de la recherche»

Commentaire / CommentaryLe principe de ce jeu, qui s’adresse essentiellement aux jeunes chercheurs, est le suivant : les participants sont invités à incarner une équipe de recherche, chargée d’étudier les impacts sanitaires inhérents à la conduite d’activités minières en Bolivie. Ce jeu interactif, qui promeut la réflexion éthique et la prise de décision par un processus dialogique et réflexif, a été conçu afin de mettre en pratique l’intégration de la prise de décision, l’interaction entre les participants et la construction conjointe de sens.The principle of this game, which is primarily aimed at junior researchers, is as follows: participants are asked to embody a research team studying the health impacts associated with the conduct of mining activities in Bolivia. This interactive game, which promotes ethical reflection and decision-making through a dialogical and reflexive process, was designed to put into practice the integration of decision-making, interaction between the participants and the co-construction of meaning

Real-time ultrasound elastography in 180 axillary lymph nodes: elasticity distribution in healthy lymph nodes and prediction of breast cancer metastases

BACKGROUND: To determine the general appearance of normal axillary lymph nodes (LNs) in real-time tissue sonoelastography and to explore the method′s potential value in the prediction of LN metastases. METHODS: Axillary LNs in healthy probands (n=165) and metastatic LNs in breast cancer patients (n=15) were examined with palpation, B-mode ultrasound, Doppler and sonoelastography (assessment of the elasticity of the cortex and the medulla). The elasticity distributions were compared and sensitivity (SE) and specificity (SP) were calculated. In an exploratory analysis, positive and negative predictive values (PPV, NPV) were calculated based upon the estimated prevalence of LN metastases in different risk groups. RESULTS: In the elastogram, the LN cortex was significantly harder than the medulla in both healthy (p=0.004) and metastatic LNs (p=0.005). Comparing healthy and metastatic LNs, there was no difference in the elasticity distribution of the medulla (p=0.281), but we found a significantly harder cortex in metastatic LNs (p=0.006). The SE of clinical examination, B-mode ultrasound, Doppler ultrasound and sonoelastography was revealed to be 13.3%, 40.0%, 14.3% and 60.0%, respectively, and SP was 88.4%, 96.8%, 95.6% and 79.6%, respectively. The highest SE was achieved by the disjunctive combination of B-mode and elastographic features (cortex >3mm in B-mode or blue cortex in the elastogram, SE=73.3%). The highest SP was achieved by the conjunctive combination of B-mode ultrasound and elastography (cortex >3mm in B-mode and blue cortex in the elastogram, SP=99.3%). CONCLUSIONS: Sonoelastography is a feasible method to visualize the elasticity distribution of LNs. Moreover, sonoelastography is capable of detecting elasticity differences between the cortex and medulla, and between metastatic and healthy LNs. Therefore, sonoelastography yields additional information about axillary LN status and can improve the PPV, although this method is still experimental

Theory of semiconductor quantum-wire based single- and two-qubit gates

A GaAs/AlGaAs based two-qubit quantum device that allows the controlled generation and straightforward detection of entanglement by measuring a stationary current-voltage characteristic is proposed. We have developed a two-particle Green's function method of open systems and calculate the properties of three-dimensional interacting entangled systems non-perturbatively. We present concrete device designs and detailed, charge self-consistent predictions. One of the qubits is an all-electric Mach-Zehnder interferometer that consists of two electrostatically defined quantum wires with coupling windows, whereas the second qubit is an electrostatically defined double quantum dot located in a second two-dimensional electron gas beneath the quantum wires. We find that the entanglement of the device can be controlled externally by tuning the tunneling coupling between the two quantum dots.Comment: 16 pages, 13 figures, RevTex4 two-column format, to appear in Phys. Rev.

Gesture retrieval and its application to the study of multimodal communication

Comprehending communication is dependent on analyzing the different modalities of conversation, including audio, visual, and others. This is a natural process for humans, but in digital libraries, where preservation and dissemination of digital information are crucial, it is a complex task. A rich conversational model, encompassing all modalities and their co-occurrences, is required to effectively analyze and interact with digital information. Currently, the analysis of co-speech gestures in videos is done through manual annotation by linguistic experts based on textual searches. However, this approach is limited and does not fully utilize the visual modality of gestures. This paper proposes a visual gesture retrieval method using a deep learning architecture to extend current research in this area. The method is based on body keypoints and uses an attention mechanism to focus on specific groups. Experiments were conducted on a subset of the NewsScape dataset, which presents challenges such as multiple people, camera perspective changes, and occlusions. A user study was conducted to assess the usability of the results, establishing a baseline for future gesture retrieval methods in real-world video collections. The results of the experiment demonstrate the high potential of the proposed method in multimodal communication research and highlight the significance of visual gesture retrieval in enhancing interaction with video content. The integration of visual similarity search for gestures in the open-source multimedia retrieval stack, vitrivr, can greatly contribute to the field of computational linguistics. This research advances the understanding of the role of the visual modality in co-speech gestures and highlights the need for further development in this area

Representations of the fundamental group of a surface in PU(p,q) and holomorphic triples

We count the connected components in the moduli space of PU(p,q)-representations of the fundamental group for a closed oriented surface. The components are labelled by pairs of integers which arise as topological invariants of the flat bundles associated to the representations. Our results show that for each allowed value of these invariants, which are bounded by a Milnor-Wood type inequality, there is a unique non-empty connected component. Interpreting the moduli space of representations as a moduli space of Higgs bundles, we take a Morse theoretic approach using a certain smooth proper function on the Higgs moduli space. A key step is the identification of the function's local minima as moduli spaces of holomorphic triples. We prove that these moduli spaces of triples are non-empty and irreducible.Comment: 6 pages, to appear in C. R. Acad. Sci. Paris Ser. I Mat

Reply to Ali & Aitchison's comment on 'Restoration of Cenozoic deformation in Asia, and the size of Greater India'

International audienceNo abstrac