The Field Guide: Applying <i>Making it Count</i> to health promotion activity with homosexually active men

This Field Guide considers a range of methods used to carry out health promotion with homosexually active men. It is a companion document to Making it count: a collaborative planning framework to reduce the incidence of HIV infection during sex between men (Hickson et al., 2003). Like Making it count, this document will be reviewed every two to three years and accompanied by training opportunities. The authors welcome comments and suggestions on this document and its use. These can be sent to: [email protected] or [email protected]. "Briefing papers" that add to the content of this guide will be produced as part of the CHAPS sector development programme. These will be available periodically from www. chapsonline.org.uk. Making it count describes a co-ordinated national framework to reduce HIV incidence occurring as a consequence of sex between men. It is intended for workers, managers, policy makers, legislators, health professionals or anyone with an investment in reducing HIV incidence among homosexually active men. This Field Guide is written for gay men's HIV health promoters. It places the theory, goals and strategic aims contained in Making it count in the context of day-to-day health promotion activity. It was developed through a range of formal interviews and informal discussion with more than 40 managers and key workers with experience and expertise in specific areas of HIV health promotion for homosexually active men. It concentrates mainly on direct contact work (Chapters 3 to 7), but also considers other types of health promotion that benefit homosexually active men by influencing the structures they live within (Chapter 8). Section one (Chapters 1 and 2) provides an overview of Making it count and the relationship between this document and that main framework. It outlines the key strategic aims of Making it count and contextualises what follows. Section two concerns direct contact with homosexually active men. Chapters 3, 4, 5 and 6 deal with different methods of carrying out direct contact work with this population. Chapter 7 considers the different target groups within the entire population of homosexually active men. It examines how to prioritise target groups using epidemiological and needs data and how best to target different groups in various settings. Section three (Chapter 8) addresses other types of health promotion interventions that are necessary including policy, community and service interventions. These are the interventions needed in order to facilitate direct contact interventions and attend to the broader determinants of sexual health for homosexually active men. It is anticipated that some (NHS) commissioners would benefit from reading this document in order to further their understanding of the range of work that they could fund. However, this document is not an implementation plan for the NHS in relation to HIV incidence among homosexually active men. Rather, Terrence Higgins Trust are currently in discussion with the Department of Health concerning further work to support the use of Making it count as the basis for Primary Care Trusts' planning and purchasing of HIV prevention activity for homosexually active men

Win Prediction in Esports: Mixed-Rank Match Prediction in Multi-player Online Battle Arena Games

Esports has emerged as a popular genre for players as well as spectators, supporting a global entertainment industry. Esports analytics has evolved to address the requirement for data-driven feedback, and is focused on cyber-athlete evaluation, strategy and prediction. Towards the latter, previous work has used match data from a variety of player ranks from hobbyist to professional players. However, professional players have been shown to behave differently than lower ranked players. Given the comparatively limited supply of professional data, a key question is thus whether mixed-rank match datasets can be used to create data-driven models which predict winners in professional matches and provide a simple in-game statistic for viewers and broadcasters. Here we show that, although there is a slightly reduced accuracy, mixed-rank datasets can be used to predict the outcome of professional matches, with suitably optimized configurations

Density Mediated Drug Release From Dapivirine Vaginal Rings Produced by Additive Manufacturing

Background: Droplet deposition modelling (DDM) is a form of 3D printing that fuses droplets of molten polymer to create each layer, providing exquisite levels of control over an object‘s design and morphology. Such manipulation allows properties including density, geometry and surface area to be manipulated in ways that have been unthinkable using conventional thermoplastic processing techniques. Here we utilise the DDM process and compare this to injection moulding to produce dapivirine (DPV) loaded vaginal rings using a pharmaceutically relevant, life science grade thermoplastic polyurethane.Methods: Vaginal rings (54.0 mm outer diameter, 4.0 mm cross sectional diameter) were fabricated by injection molding or Arburg Plastic Freeforming - a proprietary DDM process, using a hydrophobic TPU loaded with 10% w/w dapivirine. Using the DDM process, rings of 100, 50 and 10% matrix density were produced. Rings were evaluated for in vitro drug release over 29 days in an aqueous release media and assessed for thermal characteristics. Results: Daily DPV release from all ring designs ranged between 387 - 8666 μg (Day 1) and 193 - 992 μg on Day 29. DDM printed VRs with 10% infill density (68 mg DPV load) exhibited a seven fold increase in DPV release rate compared to injection molded rings containing 190 mg DPV. For DDM printed rings, there was very significant correlation between decreasing ring density and increasing DPV release rate as a percentage of total drug loading. Thermal analysis showed that the DPV melt endotherm was absent from TPU + 10% w/w DPV, suggesting that DPV was fully solubilised within the TPU at the experimental conditions.Conclusions: DDM printing on an Arburg Freeformer has been shown to create vaginal rings with a range of densities and has provided a new potential to either increase the release rate of poorly water soluble compounds or reduce the loading required to maintain a desired release rate

Using Association Rule Mining to Predict Opponent Deck Content in Android: Netrunner

As part of their design, card games often include information that is hidden from opponents and represents a strategic advantage if discovered. A player that can discover this information will be able to alter their strategy based on the nature of that information, and therefore become a more competent opponent. In this paper, we employ association rule-mining techniques for predicting item multisets, and show them to be effective in predicting the content of Netrunner decks. We then apply different modifications based on heuristic knowledge of the Netrunner game, and show the effectiveness of techniques which consider this knowledge during rule generation and prediction

Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ring

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Over half of the far-infrared background light comes from galaxies at z >= 1.2

Submillimetre surveys during the past decade have discovered a population of luminous, high-redshift, dusty starburst galaxies. In the redshift range 1 <= z <= 4, these massive submillimetre galaxies go through a phase characterized by optically obscured star formation at rates several hundred times that in the local Universe. Half of the starlight from this highly energetic process is absorbed and thermally re-radiated by clouds of dust at temperatures near 30 K with spectral energy distributions peaking at 100 microns in the rest frame. At 1 <= z <= 4, the peak is redshifted to wavelengths between 200 and 500 microns. The cumulative effect of these galaxies is to yield extragalactic optical and far-infrared backgrounds with approximately equal energy densities. Since the initial detection of the far-infrared background (FIRB), higher-resolution experiments have sought to decompose this integrated radiation into the contributions from individual galaxies. Here we report the results of an extragalactic survey at 250, 350 and 500 microns. Combining our results at 500 microns with those at 24 microns, we determine that all of the FIRB comes from individual galaxies, with galaxies at z >= 1.2 accounting for 70 per cent of it. As expected, at the longest wavelengths the signal is dominated by ultraluminous galaxies at z > 1.Comment: Accepted to Nature. Maps available at http://blastexperiment.info

BFORE: The B-mode Foreground Experiment

The B-mode Foreground Experiment (BFORE) is a proposed NASA balloon project designed to make optimal use of the sub-orbital platform by concentrating on three dust foreground bands (270, 350, and 600 GHz) that complement ground-based cosmic microwave background (CMB) programs. BFORE will survey ~1/4 of the sky with 1.7 - 3.7 arcminute resolution, enabling precise characterization of the Galactic dust that now limits constraints on inflation from CMB B-mode polarization measurements. In addition, BFORE's combination of frequency coverage, large survey area, and angular resolution enables science far beyond the critical goal of measuring foregrounds. BFORE will constrain the velocities of thousands of galaxy clusters, provide a new window on the cosmic infrared background, and probe magnetic fields in the interstellar medium. We review the BFORE science case, timeline, and instrument design, which is based on a compact off-axis telescope coupled to >10,000 superconducting detectors.Comment: 7 pages, 4 figures, conference proceedings published in Journal of Low Temperature Physic

BLAST05: Power Spectra of Bright Galactic Cirrus at Submillimeter Wavelengths

We report multi-wavelength power spectra of diffuse Galactic dust emission from BLAST observations at 250, 350, and 500 microns in Galactic Plane fields in Cygnus X and Aquila. These submillimeter power spectra statistically quantify the self-similar structure observable over a broad range of scales and can be used to assess the cirrus noise which limits the detection of faint point sources. The advent of submillimeter surveys with the Herschel Space Observatory makes the wavelength dependence a matter of interest. We show that the observed relative amplitudes of the power spectra can be related through a spectral energy distribution (SED). Fitting a simple modified black body to this SED, we find the dust temperature in Cygnus X to be 19.9 +/- 1.3 K and in the Aquila region 16.9 +/- 0.7 K. Our empirical estimates provide important new insight into the substantial cirrus noise that will be encountered in forthcoming observations.Comment: Submitted to the Astrophysical Journal. Maps and other data are available at http://blastexperiment.info