The use of the APCM-2 protocol for a preventive assessment of the motor coordination disorder

The development of motor skills that occurs gradually in a child's body and culminates around 8-9 years, if it occurs correctly, is the element that allows him to explore and take measures to interact with the surrounding reality. (Le Boulche, 1988) Only at this age we can speak of the "ability of space-time coordination", which takes shape and materializes only through the experience of consecutive motor acts with which they represent themselves, programmed in a time scan. (Piaget, 1976) These motor experiences are fundamental, because if the child has difficulty to complete the temporal scan, it would mean that he is the bearer of a movement disorder, albeit minor, called dyspraxia which without the appropriate tools, allowed by the following test could not be diagnosed. (Gargano, 2013) It was conducted A field research through the APCM-2 protocol (Sabbadini, 2018) on a sample of 281 children. Through it, we isolated 34 subjects with specific areas that were found to be deficient, therefore more compromised by suspected dyspraxia. The most important data that emerged was that the dyspractic disorder can be overcome only if identified with a timely evaluation that allows a rehabilitation program applied as quickly as possible. (Risoli, 2016) This is important because this disorder, even if defined as "minor", in the most severe cases is influential on school performance and can sometimes lead to the boy who is affected some difficulties in simple daily motor actions

Partial Evaluations and the Compositional Structure of the Bar Construction

An algebraic expression like $3 + 2 + 6$ can be evaluated to $11$, but it can also be \emph{partially evaluated} to $5 + 6$. In categorical algebra, such partial evaluations can be defined in terms of the $1$-skeleton of the bar construction for algebras of a monad. We show that this partial evaluation relation can be seen as the relation internal to the category of algebras generated by relating a formal expression to its result. The relation is transitive for many monads which describe commonly encountered algebraic structures, and more generally for BC monads on \Set, defined by the underlying functor and multiplication being weakly cartesian. We find that this is not true for all monads: we describe a finitary monad on \Set for which the partial evaluation relation on the terminal algebra is not transitive. With the perspective of higher algebraic rewriting in mind, we then investigate the compositional structure of the bar construction in all dimensions. We show that for algebras of BC monads, the bar construction has fillers for all \emph{directed acyclic configurations} in $\Delta^n$, but generally not all inner horns. We introduce several additional \emph{completeness} and \emph{exactness} conditions on simplicial sets which correspond via the bar construction to composition and invertibility properties of partial evaluations, including those arising from \emph{weakly cartesian} monads. We characterize and produce factorizations of pushouts and certain commutative squares in the simplex category in order to provide simplified presentations of these conditions and relate them to more familiar properties of simplicial sets.Comment: 90 Pages. This work arose out of the 2019 Applied Category Theory Adjoint School. The fourth author recently gave a talk on this project at the MIT Categories Seminar, recording available at https://www.youtube.com/watch?v=kMqUj3Kq1p8&list=PLhgq-BqyZ7i6Vh4nxlyhKDAMhlv1oWl5n&index=2&t=0

Weak cartesian properties of simplicial sets

Many special classes of simplicial sets, such as the nerves of categories or groupoids, the 2-Segal sets of Dyckerhoff and Kapranov, and the (discrete) decomposition spaces of G\'{a}lvez, Kock, and Tonks, are characterized by the property of sending certain commuting squares in the simplex category $\Delta$ to pullback squares of sets. We introduce weaker analogues of these properties called completeness conditions, which require squares in $\Delta$ to be sent to weak pullbacks of sets, defined similarly to pullback squares but without the uniqueness property of induced maps. We show that some of these completeness conditions provide a simplicial set with lifts against certain subsets of simplices first introduced in the theory of database design. We also provide reduced criteria for checking these properties using factorization results for pushouts squares in $\Delta$, which we characterize completely, along with several other classes of squares in $\Delta$. Examples of simplicial sets with completeness conditions include quasicategories, many of the compositories and gleaves of Flori and Fritz, and bar constructions for algebras of certain classes of monads. The latter is our motivating example.Comment: 48 pages. This work arose out of the 2019 Applied Category Theory Adjoint School. v2: Minor edits and corrections based on reviewer and editorial feedback. Formerly part of arXiv:2009.07302v

Collagen and Stretch Modulate Autocrine Secretion of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Proteins from Differentiated Skeletal Muscle Cells

Stretch-induced skeletal muscle growth may involve increased autocrine secretion of insulin-like growth factor-1 (IGF-1) since IGF-1 is a potent growth factor for skeletal muscle hypertrophy, and stretch elevates IGF-1 mRNA levels in vivo. In tissue cultures of differentiated avian pectoralis skeletal muscle cells, nanomolar concentrations of exogenous IGF-1 stimulated growth in mechanically stretched but not static cultures. These cultures released up to 100 pg of endogenously produced IGF-1/micro-g of protein/day, as well as three major IGF binding proteins of 31, 36, and 43 kilodaltons (kDa). IGF-1 was secreted from both myofibers and fibroblasts coexisting in the muscle cultures. Repetitive stretch/relaxation of the differentiated skeletal muscle cells stimulated the acute release of IGF-1 during the first 4 h after initiating mechanical activity, but caused no increase in the long-term secretion over 24-72 h of IGF-1, or its binding proteins. Varying the intensity and frequency of stretch had no effect on the long-term efflux of IGF-1. In contrast to stretch, embedding the differentiated muscle cells in a three-dimensional collagen (Type I) matrix resulted in a 2-5-fold increase in long-term IGF-1 efflux over 24-72 h. Collagen also caused a 2-5-fold increase in the release of the IGF binding proteins. Thus, both the extracellular matrix protein type I collagen and stretch stimulate the autocrine secretion of IGF-1, but with different time kinetics. This endogenously produced growth factor may be important for the growth response of skeletal myofibers to both types of external stimuli

First-Line Chemotherapy for HER-2–Negative Metastatic Breast Cancer Patients Who Received Anthracyclines as Adjuvant Treatment

Learning Objectives After completing this course, the reader will be able to: Discuss the value of retreatment with anthracyclines for HER-2–negative metastatic breast cancer patients who received anthracyclines as adjuvant treatment.Discuss the role of liposomal anthracyclines, taxanes, and combinations without anthracyclines and taxanes, or innovative treatments, including target-based agents.Comment on the weakness and quality of available evidence. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.co

La reproducción en el campo educativo : Aportes para una lectura sociológica del texto escolar

En este trabajo interesa reflexionar sobre la función reproductora de la escuela y centrar la mirada en el “Cómo”, analizando los medios y/o prácticas de que se vale para llevarla a cabo. El abordaje se realiza teniendo en cuenta la tecnología en su doble acepción: en la organización de la escuela (aspecto estático) y en el funcionamiento de la misma (aspectos dinámicos), para rescatar la lógica que impregna los procesos de enseñanza y aprendizaje y el papel del docente en ellos, como así también los soportes o recursos de que dispone. Interesa particularmente el libro de texto – o manual - para analizar el discurso que por ellos circula y el uso que los docentes hacen de él.Jornadas realizadas junto con el I Encuentro Latinoamericano de Metodología de las Ciencias Sociales.Facultad de Humanidades y Ciencias de la Educació