A parallel Block Lanczos algorithm and its implementation for the evaluation of some eigenvalues of large sparse symmetric matrices on multicomputers

In the present work we describe HPEC (High Performance Eigenvalues Computation), a parallel software package for the evaluation of some eigenvalues of a large sparse symmetric matrix. It implements an efficient and portable Block Lanczos algorithm for distributed memory multicomputers. HPEC is based on basic linear algebra operations for sparse and dense matrices, some of which have been derived by ScaLAPACK library modules. Numerical experiments have been carried out to evaluate HPEC performance on a cluster of workstations with test matrices from Matrix Market and Higham’s collections. A comparison with a PARPACKroutine is also detailed. Finally, parallel performance is evaluated on random matrices, using standard parameters

A Variable Stiffness Robotic Probe for Soft Tissue Palpation

During abdominal palpation diagnosis, a medical practitioner would change the stiffness of their fingers in order to improve the detection of hard nodules or abnormalities in soft tissue to maximize the haptic information gain via tendons. Our recent experiments using a controllable stiffness robotic probe representing a human finger also confirmed that such stiffness control in the finger can enhance the accuracy of detecting hard nodules in soft tissue. However, the limited range of stiffness achieved by the antagonistic springs variable stiffness joint subject to size constraints made it unsuitable for a wide range of physical examination scenarios spanning from breast to abdominal examination. In this letter, we present a new robotic probe based on a variable lever mechanism able to achieve stiffness ranging from 0.64 to 1.06 N·m/rad that extends the maximum stiffness by around 16 times and the stiffness range by 33 times. This letter presents the mechanical model of the novel probe, the finite element simulation as well as experimental characterization of the stiffness response for lever actuation.This work was supported by The United Kingdom Engineering and Physical Sciences Research Council under MOTION Grant EP/N03211X/2

Mathematical model and experimental characterization of vertically stacked capacitive tactile sensors

Capacitive sensors are widely used in robotics for their compactness, high resolution, high sensitivity, and large dynamic range. In this article, we present a design solution for the manufacturing of capacitive tactile sensors with enhanced dynamic range and sensitivity. Herein, we adopted the approach of exploiting the vertical direction of the sensors by creating stacks of capacitors. The validation of the proposed model is conducted by means of finite element simulations and the effectiveness of stacked capacitors in suboptimal configurations has been experimentally tested by using inkjet printing and spin coating-based fabrication techniques. Results show that these sensors exhibit an enhanced dynamic range and sensitivity with respect to common single capacitors, for a given sensors area budget. Sensitivity increases of 235% passing from one-stack to two-stack capacitors (from 5.75 to 19.3 fF/kPa) and a growth of 23% from two-stack to three-stack capacitors (from 19.3 to 23.7 fF/kPa). These results suggest that the proposed methodology could be adopted for designing tactile sensors with higher spatial resolution and higher transduction sensitivity and dynamic range, in the perspective of an integration over large areas

Imatinib-mesylate for all patients with hypereosinophilic syndrome?

Some recent papers have focused on the activity of imatinib-mesylate, a selective inhibitor of tyrosine kinase, in idiopathic hypereosinophilic syndrome (HES) [1], [2], [3] and [4]. In this setting, a possible therapeutic target was identified by Cools et al. [2], who described the fusion tyrosine-kinase gene FIP1L1/PDGFRA as the result of an interstitial deletion within chromosome 4 in nine out of sixteen (56%) patients affected by HES. Of interest, although in this study the response to imatinib was strictly correlated with the presence of FIP1L1/PDGFRA rearrangement (all patients with such a molecular lesion treated with imatinib responded), only five out of nine responding patients evidenced the abnormal transcript [2]. Among the possible alternative mechanisms for the activation of the PDGFRA tyrosine-kinase domain, these authors suggested there may be a different fusion gene

REVITALIZAÇÕES URBANAS EM ESPAÇOS PÚBLICOS: TEMPOS E FUNÇÕES DISTINTAS NO PORTO VELHO CIDADE DA CIDADE DO RIO GRANDE/RS.

Processos de “revitalização urbana” são frequentes em diversas cidades do mundo devido a espaços não utilizados herdados de diferentes tempos com diferentes atribuições de usos. Dessa forma estudos e políticas públicas voltadas ao tema se fazem significativas e imprescindíveis na contemporaneidade. Devido ao fato de, a maioria das cidades possuírem áreas ociosas e em muitos casos degradadas (vazios urbanos) justifica a necessidade de projetos voltados à revitalização. No entanto são diversos os casos de revitalização em solo urbano. Dentre os casos de revitalização, o presente trabalho se detém sobre uma área portuária, o Porto velho da cidade do Rio Grande/RS. O Porto se localiza junto ao centro histórico da cidade e é dotado de belezas naturais atribuídas aos corpos hídricos que o circundam. O antigo Porto detém uma infraestrutura que perpassa por praticamente dois séculos desde a fundação da cidade, assim como representa o berço da estrutura urbana encontrada nos dias atuais. Nesse ponto de vista podemos dizer que foi a partir do Porto Velho que a cidade se desenvolveu tanto em estrutura física quanto econômica, política e cultural

Evaluation of the effectiveness of three therapeutic protocols used in the treatment of visceral canine leishmaniosis

Leishmaniasis is a tropical and subtropical disease caused by an intracellular protozoan transmitted by a bite from a vector, mainly from the genera Phlebotomus and Lutzomyia, and affects humans and other mammals, especially dogs. The main objective in controlling canine visceral leishmaniasis is to reduce the number of human cases by reducing its prevalence in dogs. In Brazil, glucantime antimoniate and Amphotericin B, utilized for treating the disease in humans, are prohibited so that only miltefosine, which is not employed for treatment of humans, is permitted for use in dogs. This work aimed to evaluate the efficacy of three different therapeutic protocols employed in the treatment of dogs naturally infected with visceral leishmaniasis. Fifty-six (56) dogs, of both sexes, were treated and evaluated utilizing three treatment protocols. The following protocols were utilized: association of several drugs; miltefosine associated with allopurinol; and immunotherapy with anti- Leishmania vaccine associated with Allopurinol. Immunotherapy was the most efficient protocol, followed by an association of drugs and miltefosine. The use of these protocols diminishes the constant relapses of the disease. Associations of therapeutic protocols produced clinical improvement of patients even with presentation of subsequent negative serology. However, the study did not include aspects related to hemoparasitoses, thus a further study is required

Classical infratentorial superficial siderosis of the central nervous system: pathophysiology, clinical features and management

The term superficial siderosis (SS) is derived from the Greek word 'sideros', meaning iron. It includes two subtypes, distinguished by their anatomical distribution, causes and clinical features: 'classical' infratentorial SS (iSS, which sometimes also affects supratentorial regions) and cortical SS (cSS, which affects only supratentorial regions). This paper considers iSS, a potentially disabling disorder usually associated with very slow persistent or intermittent subarachnoid bleeding from a dural defect, and characterised by progressive hearing and vestibular impairment, ataxia, myelopathy and cognitive dysfunction. The causal dural defect-most often spinal but sometimes in the posterior fossa-typically follows trauma or neurosurgery occurring decades before diagnosis. Increasing recognition of iSS with paramagnetic-sensitive MRI is leading to an unmet clinical need. Given the diagnostic challenges and complex neurological impairments in iSS, we have developed a multidisciplinary approach involving key teams. We discuss pathophysiology, diagnosis and management of iSS, including a proposed clinical care pathway

Bone mineral status and metabolism in patients with Williams-Beuren syndrome.

OBJECTIVE: To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS). PATIENTS: Thirty-one children (15 females, 16 males; mean age 9.6±2.74 years) and 10 young adults (6 females, 4 males; mean age 21.4±5.11 years) with WBS were cross-sectionally evaluated and compared with two age-, sex-, and body-size-matched paediatric (155 subjects, 75 females and 80 males; mean age 9.7±2.93 years) and adult (50 subjects, 30 females and 20 males; mean age 22.3±5.42 years) healthy controls. MEASUREMENTS: We evaluated ionised and total calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, osteocalcin, bone alkaline phosphatase levels, and urinary deoxypyridinoline concentrations. We also calculated the phalangeal amplitude-dependent speed of sound (AD-SoS) and the bone transmission time (BTT) z-scores. RESULTS: WBS patients showed a significantly reduced AD-SoS z-score (p <0.001) and BTT z-score (p <0.001) compared with the controls. This finding persisted when we divided the sample into paediatric and adult patients. WBS patients also had significantly higher ionised (p <0.001) and total calcium (p <0.001) levels as well as higher PTH levels (p <0.001) compared with the controls. Furthermore, WBS children and adolescents had significantly lower serum osteocalcin levels (p <0.001) and urinary deoxypyridinoline concentrations (p <0.001) than controls. CONCLUSIONS: WBS subjects exhibit a significant reduction in bone mineral status and impaired bone metabolism. These findings point to the need for close monitoring of WBS patients

Chemi-Structural Stabilization of Formamidinium Lead Iodide Perovskite by Using Embedded Quantum Dots

The approaches to stabilize the perovskite structure of formamidinium lead iodide (FAPI) commonly result in a blue shift of the band gap, which limits the maximum photoconversion efficiency. Here, we report the use of PbS colloidal quantum dots (QDs) as a stabilizing agent, preserving the original low band gap of 1.5 eV. The surface chemistry of PbS plays a pivotal role by developing strong bonds with the black phase but weak ones with the yellow phase. As a result, a stable perovskite FAPI black phase can be formed at temperatures as low as 85 °C in just 10 min, setting a record of concomitantly fast and low-temperature formation for FAPI, with important consequences for industrialization. FAPI thin films obtained through this procedure reach an open-circuit potential (Voc) of 1.105 V, 91% of the maximum theoretical Voc, and preserve the efficiency for more than 700 h. These findings reveal the potential of strategies exploiting the chemi-structural properties of external additives to relax the tolerance factor and optimize the optoelectronic performance of perovskite materials

An apparatus for in-situ direct shear tests on snow

The article presents a prototype of a new device for measuring the shear strength of snow specimens in situ. The resistance to sliding of a snow slab on a mountain slope is a key parameter in snow mechanics. The proposed apparatus acts as a sampler, to obtain a nearly undisturbed specimen, and as a shear box, similar to those used in the laboratory, with complete control of the test procedure. The main components of the device are a pneumatic system, for the application of normal and shear forces to the specimen, a real-time controller for commanding and recording of the data, and a computer. The apparatus can be carried to the place of the experiments and operated by a team of two researchers. Calibration and preliminary tests are also described in the article