Sediment management and the renewability of floodplain clay for structural ceramics

The Netherlands has vast resources of clay that are exploited for the fabrication of structural ceramic products such as bricks and roof tiles. Most clay is extracted from the so-called embanked floodplains along the rivers Rhine and Meuse, areas that are flooded during high-discharge conditions. Riverside clay extraction is-at least in theory-compensated by deposition. Based on a sediment balance (deposition versus extraction), we explore the extent to which clay can be regarded as a renewable resource, with potential for sustainable use. Beyond that, we discuss the implications for river and sediment management, especially for the large engineering works that are to be undertaken to increase the discharge capacities of the Rhine and Meuse. Extraction rates are based on production statistics for clay, as well as those for fired end-products. Deposition rates are estimated from published and unpublished geological data (clay volumes and thicknesses, datings, etc.) and from morphological modeling studies. Comparisons between extraction and deposition are made at three different time-space scales: (1) long term (post-1850)/large scale (all Dutch floodplains), (2) present/large scale, and (3) present/site scale. The year 1850 is relevant because it approximately marks the beginning of the current, fully engineered river systems, in which depositional processes are constrained by dikes and groynes. As the Industrial Revolution began in the same period, post-1850 sediments can be identified by their pollution with heavy metals. (1) We estimate the post-1850 clay volume in situ at about 0.20 km(3), and the total extracted volume in the same period at about 0.17 km(3). This puts the net long-term average deposition rate of clay at similar to 1.3 million m(3)/year and the corresponding extraction rate at similar to 1.1 million m(3)/year. (2) Current accumulation is approximately 0.4 million m(3)/year and expected to increase, and current extraction is about 0.7 million m(3)/year and expected to decrease. (3) Clay extraction creates a depression that has an increased sediment-trapping efficiency. This local effect is not considered explicitly in large-scale morphological modeling. Based on maximum observed sedimentation rates, we estimate that replenishment of a clay site takes in the order of 150 years. As clay extraction lowers some 0.5 km(2) of floodplain yearly, a surface area of approximately 75 km(2) would be required for sustainable clay extraction. This is about 1/6 of the total surface area of the embanked floodplains. On the long term, clay extraction from the embanked floodplain depositional environment has been sustainable. At strongly decreasing deposition rates, the ratio between extraction and replenishment seems to have shifted towards unsustainable. However, current sedimentation is estimated conservatively. The site-scale approach suggests that, even if extraction would currently exceed deposition, this could be resolved with sediment management, that is, with site restoration measures aimed at higher sediment-trapping efficiency. Our results have implications for river engineering, especially where substantial digging is involved (floodplain lowering, high-discharge bypass channels, obstacle removal). First, this inevitably affects the clay resources that we studied, while resource sterilization should be avoided. Secondly, the effect that any form of digging has on subsequent sedimentation-increased rates-relates to long-term river maintenance. We conclude that floodplain clay is a renewable resource, especially if managed accordingly. Beyond that, we established that clay extraction is a significant, lasting factor in floodplain evolution along the Rhine and Meuse Rivers. The interests of the extractive industry and river managers could be served jointly with sediment management plans that are based on sediment-budget analyse

HESS Opinions On the use of laboratory experimentation: "Hydrologists, bring out shovels and garden hoses and hit the dirt"

From an outsider's perspective, hydrology combines field work with modelling, but mostly ignores the potential for gaining understanding and conceiving new hypotheses from controlled laboratory experiments. Sivapalan (2009) pleaded for a question- and hypothesis-driven hydrology where data analysis and top-down modelling approaches lead to general explanations and understanding of general trends and patterns. We discuss why and how such understanding is gained very effectively from controlled experimentation in comparison to field work and modelling. We argue that many major issues in hydrology are open to experimental investigations. Though experiments may have scale problems, these are of similar gravity as the well-known problems of fieldwork and modelling and have not impeded spectacular progress through experimentation in other geosciences

Анализ составляющих теплового баланса системы "прокатный стан - прокатываемая полоса" и пути снижения энергозатрат в процессе сортовой прокатки

Выполнен анализ составляющих теплового баланса системы «прокатный стан – прокатываемая полоса». Рассмотрены основные направления решения температурной задачи сортовой прокатки. Предложен ряд мероприятий, позволяющих снизить расход энергоресурсов на прокатку и уменьшить расходную часть теплового баланса системы «прокатный стан – прокатываемая полоса»

Історія становлення міжнародного суду ООН

Досліджується історія розвитку міжнародного правосуддя та діяльності інституту судової системи на міжнародному рівні, особливості становлення Міжнародного Суду ООН та його попередниці Постійної Палати міжнародного правосуддя в рамках Ліги Націй.Исследуется история развития международного правосудия и деятельности института судебной системы на международном уровне, особенности становления Международного Суда ООН и его предшественника Постоянной Палаты международного правосудия в рамках Лиги Наций.In the article author explores the history of international justice and the judicial system of the institute on the international level.Feature of theformation International Court of Justice and its predecessor the Permanent Court of International Justice by the League of Nations

Dynamics and transport near quantum-critical points

The physics of non-zero temperature dynamics and transport near quantum-critical points is discussed by a detailed study of the O(N)-symmetric, relativistic, quantum field theory of a N-component scalar field in $d$ spatial dimensions. A great deal of insight is gained from a simple, exact solution of the long-time dynamics for the N=1 d=1 case: this model describes the critical point of the Ising chain in a transverse field, and the dynamics in all the distinct, limiting, physical regions of its finite temperature phase diagram is obtained. The N=3, d=1 model describes insulating, gapped, spin chain compounds: the exact, low temperature value of the spin diffusivity is computed, and compared with NMR experiments. The N=3, d=2,3 models describe Heisenberg antiferromagnets with collinear N\'{e}el correlations, and experimental realizations of quantum-critical behavior in these systems are discussed. Finally, the N=2, d=2 model describes the superfluid-insulator transition in lattice boson systems: the frequency and temperature dependence of the the conductivity at the quantum-critical coupling is described and implications for experiments in two-dimensional thin films and inversion layers are noted.Comment: Lectures presented at the NATO Advanced Study Institute on "Dynamical properties of unconventional magnetic systems", Geilo, Norway, April 2-12, 1997, edited by A. Skjeltorp and D. Sherrington, Kluwer Academic, to be published. 46 page

Endoscopic full-thickness resection of T1 colorectal cancers:a retrospective analysis from a multicenter Dutch eFTR registry

Background Complete endoscopic resection and accurate histological evaluation for T1 colorectal cancer (CRC) are critical in determining subsequent treatment. Endoscopic full-thickness resection (eFTR) is a new treatment option for T1 CRC<2cm. We aimed to report clinical outcomes and short-term results. Methods Consecutive eFTR procedures for T1 CRC, prospectively recorded in our national registry between November 2015 and April 2020, were retrospectively analyzed. Primary outcomes were technical success and R0 resection. Secondary outcomes were histological risk assessment, curative resection, adverse events, and short-term outcomes. Results We included 330 procedures: 132 primary resections and 198 secondary scar resections after incomplete T1 CRC resection. Overall technical success, R0 resection, and curative resection rates were 87.0% (95% confidence interval [CI] 82.7%-90.3%), 85.6% (95%CI 81.2%-89.2%), and 60.3% (95%CI 54.7%-65.7%). Curative resection rate was 23.7% (95%CI 15.9%-33.6%) for primary resection of T1 CRC and 60.8% (95%CI 50.4%-70.4%) after excluding deep submucosal invasion as a risk factor. Risk stratification was possible in 99.3%. The severe adverse event rate was 2.2%. Additional oncological surgery was performed in 49/320 (15.3%), with residual cancer in 11/49 (22.4%). Endoscopic follow-up was available in 200/242 (82.6%), with a median of 4 months and residual cancer in 1 (0.5%) following an incomplete resection. Conclusions eFTR is relatively safe and effective for resection of small T1 CRC, both as primary and secondary treatment. eFTR can expand endoscopic treatment options for T1 CRC and could help to reduce surgical overtreatment. Future studies should focus on long-term outcomes

Right ventricular peak systolic longitudinal strain is a sensitive marker for right ventricular deterioration in adult patients with tetralogy of Fallot

The aim of this study was to evaluate the feasibility of right ventricular (RV) longitudinal peak systolic strain (LPSS) assessment for the follow-up of adult patients with corrected tetralogy of Fallot (TOF). Adult patients (n = 18) with corrected TOF underwent echocardiography and CMR twice with a time interval of 4.2 ± 1.7 years. RV performance was derived from CMR, and included RV volumes and ejection fraction (EF). LPSS was calculated globally (GLPSS) and in the RV free wall (LPSS FW), with echocardiographic speckle-tracking strain-analysis. Baseline (G)LPSS values were compared between patients and healthy controls; the relation between (G)LPSS and CMR parameters was evaluated and the changes in (G)LPSS and CMR parameters during follow-up were compared. GLPSS and LPSS FW were significantly reduced in patients as compared to controls (−14.9 ± 0.7% vs. −21.6 ± 0.9% and −15.5 ± 0.9% vs. −22.7 ± 1.5%, P < 0.01). Moderate agreement between LPSS and CMR parameters was observed. RV EF remained unchanged during follow-up, whereas GLPSS and LPSS FW demonstrated a significant reduction. RVEF showed a 1% increase, whereas GLPSS decreased by 14%, and LPSS FW by 27%. RV LPSS is reduced in TOF patients as compared to controls; during follow-up RV EF remained unchanged whereas LPSS decreased suggesting that RV LPSS may be a sensitive marker to detect early deterioration in RV performance

Inert coupling of IRDye800CW to monoclonal antibodies for clinical optical imaging of tumor targets

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Targeted next-generation sequencing has incremental value in the diagnostic work-up of patients with suspect pancreatic masses: a multi-center prospective cross sectional study

BackgroundThe diagnostic process of patients with suspect pancreatic lesions is often lengthy and prone to repeated diagnostic procedures due to inconclusive results. Targeted Next-Generation Sequencing (NGS) performed on cytological material obtained with fine needle aspiration (FNA) or biliary duct brushing can speed up this process. Here, we study the incremental value of NGS for establishing the correct diagnosis, and subsequent treatment plan in patients with inconclusive diagnosis after regular diagnostic work-up for suspect pancreatic lesions.Methods In this prospective cross-sectional cohort study, patients were screened for inclusion in four hospitals. NGS was performed with AmpliSeq Cancer Hotspot Panel v2 and v4b in patients with inconclusive cytology results or with an uncertain diagnosis. Diagnostic results were evaluated by the oncology pancreatic multidisciplinary team. The added value of NGS was determined by comparing diagnosis (malignancy, cystic lesion or benign condition) and proposed treatment plan (exploration/resection, neoadjuvant chemotherapy, follow-up, palliation or repeated FNA) before and after integration of NGS results. Final histopathological analysis or a 6-month follow-up period were used as the reference standard in case of surgical intervention or non-invasive treatment, respectively.Results In 50 of the 53 included patients, cytology material was sufficient for NGS analysis. Diagnosis before and after integration of NGS results differed in 24% of the patients. The treatment plan was changed in 32% and the diagnosis was substantiated by the NGS data in 44%. Repetition of FNA/brushing was prevented in 14% of patients. All changes in treatment plan were correctly made after integration of NGS. Integration of NGS increased overall diagnostic accuracy from 68% to 94%.Interpretation This study demonstrates the incremental diagnostic value of NGS in patients with an initial inconclusive diagnosis. Integration of NGS results can prevent repeated EUS/FNA, and can also rigorously change the final diagnosis and treatment plan.Surgical oncolog