Influence of Different European Code Provisions for Capacity Design on the Seismic Performance of Reinforced Concrete Frames

[EN] Performance-based seismic codes ensure proper inelastic behaviour of reinforced concrete frames through capacity design, among others. This strategy relies not only on avoiding brittle failures and providing ductility to plastic hinges but also in their distribution within the frame aimed at a greater number of storeys involved in the eventual collapse mechanism. Although codes are generally in agreement to some basic principles in order to ensure capacity design, they show some discrepancies regarding the specific strategies. In this paper, capacity design provisions proposed by some European current codes-Eurocode 8, Italian NTC, and Spanish NCSE-02-are compared, and their effectiveness is discussed. The alternative formulation proposed by Italian code for "strong column-weak beam" turns out to be not suitable under specific circumstances, such as with large gravity loads or significant cantilever deformation in lower storeys. Regarding the value of axial load in columns to be considered for the calculation of shear and moment capacities, provisions in the three codes could eventually cause unconservative design for perimeter columns. The Spanish whole set of provisions is proved to not be effective due to their different fundamentals-they are based on overstrength instead of capacity. For all the three cases, some alternative procedures are suggested in this work.Gómez-Martínez, F.; Perez-Garcia, A. (2023). Influence of Different European Code Provisions for Capacity Design on the Seismic Performance of Reinforced Concrete Frames. Buildings. 13(8). https://doi.org/10.3390/buildings1308205113

Yielding and Ultimate Deformations of Wide and Deep Reinforced Concrete Beams

[EN] Current formulations proposed by Eurocode 8 part 3 for the inelastic deformations of existing reinforced concrete members are assessed separately for wide beams (WB) and conventional deep beams (DB). The current approach, based on a large experimental database of members, predicts larger ultimate chord rotation but lower chord rotation ductility for WB rather than for DB despite the similar curvature ductility, due to lower plastic hinge lengths in WB. However, if the data are disaggregated into DB and WB, predicted chord rotations are consistently conservative for DB and not conservative for WB if compared with experimental values, especially at ultimate deformation. Thus, plastic hinge length may be even greater for DB in comparison to WB. Therefore, some feasible corrections of the formulations for chord rotations are proposed, in order to reduce the bias and thus increase the robustness of the model for cross-section shape variability.Gómez-Martínez, F.; Perez-Garcia, A. (2022). Yielding and Ultimate Deformations of Wide and Deep Reinforced Concrete Beams. Buildings. 12(11). https://doi.org/10.3390/buildings12112015121

Generalized FAST approach for seismic assessment of infilled RC MRF buildings: application to the 2011 Lorca earthquake

A generalized formulation of FAST vulnerability method for Reinforced Concrete Moment Resisting Frame (RC-MRF) buildings with non-uniform distribution of masonry infills in elevation is presented. This method belongs to the wider family of spectral-based methodologies. It was already proposed for uniformly infilled frames, and then applied to different earthquakes for benchmarking purposes. The new generalized approach allows us to consider a reduction of the amount of infills at the ground floor. Thus, this new version of FAST is capable of computing all intermediate situations between the opposite cases: uniformly infilled and pilotis (no infills at ground storey) MRF. Finally, this generalized FAST method is applied to the case of the Lorca (Spain) 2011 earthquake, using parameters according to the local construction practice of the area. Results show a fair agreement with damage survey data.Gómez-Martínez, F.; Perez-Garcia, A.; De Luca, F.; Verderame, GM. (2014). Generalized FAST approach for seismic assessment of infilled RC MRF buildings: application to the 2011 Lorca earthquake. WIT Transactions on the Built Environment. 141:427-443. doi:10.2495/SUSI140371S42744314

H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites associated with aging. As in differentiated cells, hypermethylated sequences were enriched in chromatin repressive marks. Most importantly, hypomethylated CpG sites were strongly enriched in the active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type–independent chromatin signature of DNA hypomethylation during aging. Analysis of scedasticity showed that interindividual variability of DNA methylation increased during aging in MSCs and differentiated cells, providing a new avenue for the identification of DNA methylation changes over time. DNA methylation profiling of genetically identical individuals showed that both the tendency of DNA methylation changes and scedasticity depended on nongenetic as well as genetic factors. Our results indicate that the dynamics of DNA methylation during aging depend on a complex mixture of factors that include the DNA sequence, cell type, and chromatin context involved and that, depending on the locus, the changes can be modulated by genetic and/or external factors

Ibero-American Consensus on Low- and No-Calorie Sweeteners: Safety, Nutritional Aspects and Benefits in Food and Beverages

International scientific experts in food, nutrition, dietetics, endocrinology, physical activity, paediatrics, nursing, toxicology and public health met in Lisbon on 2-4 July 2017 to develop a Consensus on the use of low- and no-calorie sweeteners (LNCS) as substitutes for sugars and other caloric sweeteners. LNCS are food additives that are broadly used as sugar substitutes to sweeten foods and beverages with the addition of fewer or no calories. They are also used in medicines, health-care products, such as toothpaste, and food supplements. The goal of this Consensus was to provide a useful, evidence-based, point of reference to assist in efforts to reduce free sugars consumption in line with current international public health recommendations. Participating experts in the Lisbon Consensus analysed and evaluated the evidence in relation to the role of LNCS in food safety, their regulation and the nutritional and dietary aspects of their use in foods and beverages. The conclusions of this Consensus were: (1) LNCS are some of the most extensively evaluated dietary constituents, and their safety has been reviewed and confirmed by regulatory bodies globally including the World Health Organisation, the US Food and Drug Administration and the European Food Safety Authority; (2) Consumer education, which is based on the most robust scientific evidence and regulatory processes, on the use of products containing LNCS should be strengthened in a comprehensive and objective way; (3) The use of LNCS in weight reduction programmes that involve replacing caloric sweeteners with LNCS in the context of structured diet plans may favour sustainable weight reduction. Furthermore, their use in diabetes management programmes may contribute to a better glycaemic control in patients, albeit with modest results. LNCS also provide dental health benefits when used in place of free sugars; (4) It is proposed that foods and beverages with LNCS could be included in dietary guidelines as alternative options to products sweetened with free sugars; (5) Continued education of health professionals is required, since they are a key source of information on issues related to food and health for both the general population and patients. With this in mind, the publication of position statements and consensus documents in the academic literature are extremely desirable

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD