Predicting Child Molester Typologies: Can Control Methods, Violence, and Location Predict MTC:CM3 Axis I Typology?

Child molesters have been a key focus of public fear so much that many policies have been created that focus on reducing public panic rather than being supported by empirical evidence. Knowing the psychological motivations and patterns of this particular population is important in order to advance research that can affect future investigations, policies and laws concerning the safety of the public. The purpose of this study was to determine whether the use of crime scene characteristics can accurately predict child molester typology using the MTC:CM3 Axis I Fixation and Social Competence levels. The crime scene characteristics: control methods (use of threat or weapons), violence, and location (whether offense was in a child-dense location or not) were used in order to predict high or low levels on both the MTC Fixation and MTC Social Competence scale. It was hypothesized that those with higher levels of fixation and lower levels of social competence would be more likely to use control methods, violence, and choose a child dense location for the offense than those with lower levels of fixation and higher levels of social competence. Archival data from 439 child molesters was gathered and coded from offender files in a state prison system. Two binary logistic regressions were performed and results indicated that these did not predict MTC Fixation and MTC Social Competence levels, thus would not aide in the prediction of child molester typology. Future research should examine additional variables as well as the entirety of the MTC:CM3 scale in order to obtain more information that can aid in the use of crime scene characteristics as predictors for child molester typologies

Hydrophobic cis-platinum complexes efficiently incorporated into liposomes

The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are carboxylato monoanions bearing a hydrophobic radical function or a single carboxylato dianion bearing a hydrophobic radical function and R.sub.3 is a vicinal diaminoalkane or vicinal diaminocycloalkane. The complex is substantially soluble in methanol or chloroform and substantially insoluble in water. Said complex may be incorporated into phospholipid liposomes. Such platinum complexes encapsulated in phospholipid liposomes are useful for chemotherapy of platinum complex-sensitive tumors.Board of Regents, University of Texas Syste

A clarification on prevailing misconceptions in unimodular gravity

The traditional presentation of Unimodular Gravity (UG) consists on indicating that it is an alternative theory of gravity that restricts the generic diffeomorphism invariance of General Relativity. In particular, as often encountered in the literature, unlike General Relativity, Unimodular Gravity is invariant solely under volume-preserving diffeomorphisms. That characterization of UG has led to some confusion and incorrect statements in various treatments on the subject. For instance, sometimes it is claimed (mistakenly) that only spacetime metrics such that $|$det $g_{\mu \nu}| = 1$ can be considered as valid solutions of the theory. Additionally, that same (incorrect) statement is often invoked to argue that some particular gauges (e.g. the Newtonian or synchronous gauge) are not allowed when dealing with cosmological perturbation theory in UG. The present article is devoted to clarify those and other misconceptions regarding the notion of diffeomorphism invariance, in general, and its usage in the context of UG, in particular.Comment: 21 pages + Refs, 2 figure

UC-177 Day Easy Phone Application

DayEasy is a phone application that is designed to promote clean eating and workout habits by providing services such as a calendar, workout planner, hydration and calorie journal, pedometer, fasting timer, and a meal planner. The application will have the functions to: • The user will be able to create an account. • The user will be able to change their password when they forget it. This will be done by sending an email. • The user will be able to save their sign in credentials. • The user will be able to view their daily schedule. • The user will be able to create new tasks. • These tasks are repeatable. • The user will be able to add how much water they drink in oz/ml • The user can set a daily drinking goal. • The user will be able to see how many steps they have taken. • The user can set a daily step goal. • The user will be able to plan their workout by selecting various customized movements. • The user will be able to select a movement (possibly a GIF) and see information about it. • The user will be able to go to muscle option and select a muscle part they want to work on and plan their workout. • The user will be able to plan their meals by keeping a journal. This journal will include calories. • The user will be able to pick a customized meal plan based on dietary selections. • The user will be able to add up their calories. • The user will be able to set a daily calorie goal

The Hilbert space of Chern-Simons theory on the cylinder. A Loop Quantum Gravity approach

As a laboratory for loop quantum gravity, we consider the canonical quantization of the three-dimensional Chern-Simons theory on a noncompact space with the topology of a cylinder. Working within the loop quantization formalism, we define at the quantum level the constraints appearing in the canonical approach and completely solve them, thus constructing a gauge and diffeomorphism invariant physical Hilbert space for the theory. This space turns out to be infinite dimensional, but separable.Comment: Minor changes and some references added. Latex, 16 pages, 1 figur

Simple Microcontact Printing Technique to Obtain Cell Patterns by Lithography Using Grayscale, Photopolymer Flexographic Mold, and PDMS

Microcontact printing using PDMS embossing tools and its variations have aroused the interest of a wide spectrum of research fields, hence the feasibility of defining micro and nanoscale patterns. In this work, we have proposed and demonstrated a novel lithography method based on grayscale patterns printed in a flexographic photopolymer mold and transferred to epoxy resin and a single PDMS stamp to obtain different microprint pattern structures. The geometry of the patterns can be modified by adjusting the layout and grayscale of the stamp patterns. The functionality of this contact printing methodology was validated by generating human induced pluripotent stem cells (hiPSC) patterns. These specific micropatterns can be very useful for achieving complex differentiation in cell lines such as hiPSC. Microfabrication through the new technique provides a promising alternative to conventional lithography for constructing complex aligned surfaces; these structures could be used as components of biological patterns or microfluidic devices.Fil: Gimenez, Rocio. Universidad Tecnológica Nacional; ArgentinaFil: Pérez Sosa, Camilo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Tecnológica Nacional; ArgentinaFil: Bourguignon, Natalia. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miriuka, Santiago Gabriel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bhansali, Shekhar. University of Florida; Estados UnidosFil: Arroyo, Carlos R.. Universidad de Las Fuerzas Armadas; EcuadorFil: Debut, Alexis. Universidad de Las Fuerzas Armadas; EcuadorFil: Lerner, Betiana. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez, Maximiliano Sebastian. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Probing the Conformational States of Thimet Oligopeptidase in Solution

Thimet oligopeptidase (TOP) is a metallopeptidase involved in the metabolism of oligopeptides inside and outside cells of various tissues. It has been proposed that substrate or inhibitor binding in the TOP active site induces a large hinge‐bending movement leading to a closed structure, in which the bound ligand is enclosed. The main goal of the present work was to study this conformational change, and fluorescence techniques were used. Four active TOP mutants were created, each equipped with a single‐Trp residue (fluorescence donor) and a p‐nitro‐phenylalanine (pNF) residue as fluorescence acceptor at opposite sides of the active site. pNF was biosynthetically incorporated with high efficiency using the amber codon suppression technology. Inhibitor binding induced shorter Donor‐Acceptor (D‐A) distances in all mutants, supporting the view that a hinge-like movement is operative in TOP. The activity of TOP is known to be dependent on the ionic strength of the assay buffer and D‐A distances were measured at different ionic strengths. Interestingly, a correlation between the D‐A distance and the catalytic activity of TOP was observed: the highest activities corresponded to the shortest D‐A distances. In this study for the first time the hinge‐bending motion of a metallopeptidase in solution could be studied, yielding insight about the position of the equilibrium between the open and closed conformation. This information will contribute to a more detailed understanding of the mode of action of these enzymes, including therapeutic targets like neurolysin and angiotensin‐converting enzyme 2 (ACE2)

Phase imaging of irradiated foils at the OMEGA EP facility using phase-stepping X-ray Talbot–Lau deflectometry

Producción CientíficaDiagnosing the evolution of laser-generated high energy density (HED) systems is fundamental to develop a correct understanding of the behavior of matter under extreme conditions. Talbot–Lau interferometry constitutes a promising tool, since it permits simultaneous single-shot X-ray radiography and phase-contrast imaging of dense plasmas. We present the results of an experiment at OMEGA EP that aims to probe the ablation front of a laser-irradiated foil using a Talbot–Lau X-ray interferometer. A polystyrene (CH) foil was irradiated by a laser of 133 J, 1 ns and probed with 8 keV laser-produced backlighter radiation from Cu foils driven by a short-pulse laser (153 J, 11 ps). The ablation front interferograms were processed in combination with a set of reference images obtained ex situ using phase-stepping. We managed to obtain attenuation and phase-shift images of a laser-irradiated foil for electron densities above 1e22 cm−3. These results showcase the capabilities of Talbot–Lau X-ray diagnostic methods to diagnose HED laser-generated plasmas through high-resolution imaging.The work has been supported by Research Grant No. PID2019-108764RB-I00 from the Spanish Min istry of Science and Innovatio

Effect of miR-660-5p in breast cancer progression

Background: Breast cancer (BC) is the most diagnosed cancer in women worldwide. MicroRNAs (miRNAs) participate in different processes of BC and their deregulation can cause them to act as oncogenes or tumor suppressors, participating in cancer progression. Using the TCGA (The Cancer Genome Atlas) database, we found that miR-660-5p significantly overexpressed and associated with poor survival in patients with this pathology. Moreover, it is reported that miR-660-5p can induce BC progression through transcription factor CP2 (TFCP2) and the downregulation of tet methylcytosine dioxygenase 2 (TET2). In this project, we propose to identify the role of miR-660-5p in proliferation, migration, invasion, angiogenesis, and the possible targets involved in these processes in BC cell lines. Methods: Basal levels of miR-660-5p were determined in BC cells MDA-MB-231 and MCF-7, and in human epithelial breast cells MCF-10A by RT-qPCR. The effect of miR-660-5p was evaluated on proliferation, migration, and invasion processes in MDA-MB-231 and MCF-7 cells. HUVEC cells were used to assess angiogenesis. All cell lines were transfected with miR-660-5p inhibitor. Analysis of nine miRNA-target prediction databases was made to identify targets of miR-660-5p. We selected the targets genes predicted by at least three of these programs, and their expression were evaluated in MDA-MB-231 cells by RT-qPCR in a customized plate. We validated those results with Western blot. Results: We found that miR-660-5p is significantly upregulated in MDA-MB-231 and MCF-7, compared to MCF-10A cells. In addition, we observed a significant decrease in proliferation, migration, and invasion in BC cells transfected with miR-660-5p inhibitor, compared to nontreated cells and miRNA inhibitor negative control cells. Similarly, we observed a significant decrease in angiogenesis of HUVEC cells transfected with miR-660-5p inhibitor. Furthermore, of all the miR-660-5p target genes identified by prediction databases, 17 were selected, and of these, three were observed upregulated and one downregulated. We found that CD8A, LIFR and TMEM41B are reported as tumor suppressors in different types of cancer. We validated those results by Western blot, observing an increase in TMEM41B protein levels in the group of cells transfected with miR-660 inhibitor compared to nontreated cells and miRNA inhibitor negative control cells. Conclusions: The results show that miR-660-5p is upregulated and involved in proliferation, migration, invasion, and angiogenesis of BC, which may lead us to suggest that this miRNA act as an onco-miRNA. In addition, we found that TMEM41B could be a potential target of miR-660-5p

Dual-comb spectroscopy with tailored spectral broadening in Si3N4 nanophotonics

Si N waveguides, pumped at 1550 nm, can provide spectrally smooth, broadband light for gas spectroscopy in the important 2 &mu;m to 2.5 &mu;m atmospheric water window, which is only partially accessible with silica-fiber based systems. By combining Er fiber frequency combs and supercontinuum generation in tailored Si N waveguides, high signal-to-noise dual-comb spectroscopy spanning 2 &mu;m to 2.5 &mu;m is demonstrated. Acquired broadband dual-comb spectra of CO and CO agree well with database line shape models and have a spectral-signal-to-noise as high as 48/&radic;s, showing that the high coherence between the two combs is retained in the Si N supercontinuum generation. The dual-comb spectroscopy figure of merit is 6 &times; 10 /&radic;s, equivalent to that of all-fiber dual-comb spectroscopy systems in the 1.6 &mu;m band. based on these results, future dual-comb spectroscopy can combine fiber comb technology with Si N waveguides to access new spectral windows in a robust non-laboratory platform.</p