Correction of ischemic optic neuropathy in rats by carbamylated darbepoetin

The protective effects of carbamylated darbepoetin on the model of ischemic optic neuropathy in rats were revealed. To increase the effectiveness of pharmacological correction of experimental ischemic optic neuropathy in an experiment by using carbamylated darbepoetin. Measuring the microcirculation level in the retina of rats was carried out using laser Doppler flowmetry (LDF

Application of quantitative and qualitative methods for determination of priority development directions of companies implementing lean manufacturing

This article covers the issues of integration of qualitative and quantitative methods applied when justifying management decision-making in companies implementing lean manufacturing. The authors defined goals and subgoals and justified the evaluation criteria which lead to the increased company value if achieved. The authors identify the most important top-level rating indicators: receiving a profit and increase in cash flow. The lower level includes criteria: 1) created value, sales volume, productivity, customer satisfaction; 2) net cash flow, turnover of current assets, EBITDA; 3) amount of accounts receivable; acceleration of the time from receipt of the order to receipt of money, expansion of own dealer network; 4) loss reduction, reduction of indirect costs, reducing inventory. The application of the analytic hierarchy process and the involvement of experts of various services allow accelerating management decision-making with regard to the determination of the priority development directions in the current economic conditions and making the process objective to the maximum.Keywords: analytic hierarchy process, lean manufacturing, management accounting, decision-makin

A comparative evaluation of the efficacy of dimethylaminoethanol derivative 7-16, C7070 and picamilon in correction of experimental hypertensive neuroretinopathy

The efficacy of dimethylaminoethanol (DMAE) derivative 7-16, substance C7070 in comparison with picamylon in hypertensive neuroretinopathy model in white laboratory rats was evaluate

Innovations in cruise tourism

У статті були розглянуті інновації круїзного туризму, проаналізовано їх вплив на круїзну галузь в цілому. Були дані характеристики основним нововведенням круїзної галузі, виявлено тенденції їх розвитку, а також обґрунтована подальша необхідність їх впровадження

Networking cooperation as one of foundation of dynamic evolution of educational institutions of Secondary professional vocational education and higher education in the industrial region

In article described the effectiveness of networking cooperation, as modern novel technology in pedagogical educationВ статье рассматривается эффективность сетевого взаимодействия как современной инновационной технологии в педагогическом образовани

Correction of retinal angiopathy of hypertensive type by dimethylaminoethanol derivative 19-16 in experiment

To increase the effectiveness of pharmacological correction of retinal angiopathy of hypertensive type using a new dimethylaminoethanol (DMAE) derivative 19-1

Correction of retinal angiopathy of hypertensive type by minoxidil, sildenafil in experiment

For the study of retinoprotective properties of pharmacological agents a model of retinal angiopathy of hypertensive type was created against the background of N-nitro-L-arginine methyl ester (L-NAME) administration in a dose 12.5 mg/kg rat body weight for 28 days. Detection of preconditioning properties of pharmacological agents may be a new approach in the correction and prevention of retinal angiopathy, which is the initial part of hypertensive retinopath

Correction of Experimental Retinal Ischemia by L-Isomer of Ethylmethylhydroxypyridine Malate

An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative-L-isomer of ethylmethylhydroxypyridine malat

Correction of retinal ischemia/reperfusion by 3-(1H-benzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in experiment

Results of ocular fundus studies revealed the most pronounced protective effects of 3-(1Hbenzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in a dose 50 mg/kg on the model of retinal ischemiareperfusion in Wistar rats, which is reflected in the restoration of the optic disc. Correction of retinal ischemiareperfusion by 3-(1H-benzimidazol-2-il)-1,2,2-trimethyl cyclopentancarbonic acid in a dose 50 mg/kg leads to higher values of the coefficient b/a of electroretinography after 72 hours of reperfusion compared to the group with pathology correction by the same drug in a dose 10 mg/kg, which indicates the restoration of the electrophysiological state of the retin

The development of hypertensive neuroretinopathy model on wistar rats

A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on the background of single increased intraocular pressure (IOP) to 110 mmHg. As a result of the interim evaluation of pathology simulation mode the most optimal was a model of hypertensive neuroretinopathy with 5-minute increased IOP at day 26 of the experiment on the background of L-NAME for further study of neuroretinoprotective properties of pharmacological agent