Colaboração científica dos docentes do Curso de Farmacologia da UFSC: Aplicação de análise de redes sociais

TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação, Curso de BiblioteconomiaA monografia apresenta as colaborações e coocorrências científicas dos docentes que fazem parte do Departamento de Farmacologia do CCB (Centro de Ciências Biológicas), da Universidade Federal de Santa Catarina (UFSC) que publicam estudos (livros, artigos e trabalhos apresentados em eventos).The monograph presents the scientific collaborations and co-occurrences of teachers who are part of the Department of Pharmacology of the CCB (Center for Biological Sciences), Federal University of Santa Catarina (UFSC) which publish research (books, articles and papers presented at events)

Approximate and timing-speculative hardware design for high-performance and energy-efficient video processing

Since the end of transistor scaling in 2-D appeared on the horizon, innovative circuit design paradigms have been on the rise to go beyond the well-established and ultraconservative exact computing. Many compute-intensive applications – such as video processing – exhibit an intrinsic error resilience and do not necessarily require perfect accuracy in their numerical operations. Approximate computing (AxC) is emerging as a design alternative to improve the performance and energy-efficiency requirements for many applications by trading its intrinsic error tolerance with algorithm and circuit efficiency. Exact computing also imposes a worst-case timing to the conventional design of hardware accelerators to ensure reliability, leading to an efficiency loss. Conversely, the timing-speculative (TS) hardware design paradigm allows increasing the frequency or decreasing the voltage beyond the limits determined by static timing analysis (STA), thereby narrowing pessimistic safety margins that conventional design methods implement to prevent hardware timing errors. Timing errors should be evaluated by an accurate gate-level simulation, but a significant gap remains: How these timing errors propagate from the underlying hardware all the way up to the entire algorithm behavior, where they just may degrade the performance and quality of service of the application at stake? This thesis tackles this issue by developing and demonstrating a cross-layer framework capable of performing investigations of both AxC (i.e., from approximate arithmetic operators, approximate synthesis, gate-level pruning) and TS hardware design (i.e., from voltage over-scaling, frequency over-clocking, temperature rising, and device aging). The cross-layer framework can simulate both timing errors and logic errors at the gate-level by crossing them dynamically, linking the hardware result with the algorithm-level, and vice versa during the evolution of the application’s runtime. Existing frameworks perform investigations of AxC and TS techniques at circuit-level (i.e., at the output of the accelerator) agnostic to the ultimate impact at the application level (i.e., where the impact is truly manifested), leading to less optimization. Unlike state of the art, the framework proposed offers a holistic approach to assessing the tradeoff of AxC and TS techniques at the application-level. This framework maximizes energy efficiency and performance by identifying the maximum approximation levels at the application level to fulfill the required good enough quality. This thesis evaluates the framework with an 8-way SAD (Sum of Absolute Differences) hardware accelerator operating into an HEVC encoder as a case study. Application-level results showed that the SAD based on the approximate adders achieve savings of up to 45% of energy/operation with an increase of only 1.9% in BD-BR. On the other hand, VOS (Voltage Over-Scaling) applied to the SAD generates savings of up to 16.5% in energy/operation with around 6% of increase in BD-BR. The framework also reveals that the boost of about 6.96% (at 50°) to 17.41% (at 75° with 10- Y aging) in the maximum clock frequency achieved with TS hardware design is totally lost by the processing overhead from 8.06% to 46.96% when choosing an unreliable algorithm to the blocking match algorithm (BMA). We also show that the overhead can be avoided by adopting a reliable BMA. This thesis also shows approximate DTT (Discrete Tchebichef Transform) hardware proposals by exploring a transform matrix approximation, truncation and pruning. The results show that the approximate DTT hardware proposal increases the maximum frequency up to 64%, minimizes the circuit area in up to 43.6%, and saves up to 65.4% in power dissipation. The DTT proposal mapped for FPGA shows an increase of up to 58.9% on the maximum frequency and savings of about 28.7% and 32.2% on slices and dynamic power, respectively compared with stat

Crítica à educação ambiental no ensino de geografia: discussão e propostas pedagógicas

Este trabajo está impulsado por preguntas teóricas y metodológicas sobre las prácticas de educación ambiental en la enseñanza de la geografía. El objetivo es debatir si estas actividades pedagógicas tienen una naturaleza cuestionable de los problemas ambientales. Adopta un examen bibliográfico y propuestas de actividades pedagógicas de acuerdo con la enseñanza geográfica crítica y aplicable. La crítica del materialismo histórico-dialéctico guía las discusiones sobre el problema ambiental, la enseñanza de la geografía, el papel de los profesores y las alternativas posibles de actividades didácticas. La educación ambiental se discute en oposición a las prácticas conservadoras. Se presentan tres propuestas pedagógicas que impregnan contenidos curriculares de la enseñanza de la geografía para la escuela secundaria, relacionándose a la educación ambiental. Son propuestas adaptables a diferentes realidades educativas, que exigen la participación activa de profesores y estudiantes. Es esencial que las discusiones y propuestas se conviertan en prácticas efectivas.This work is driven by theoretical-methodological questions concerning environmental education practices in Geography teaching. The objective is to discuss whether these pedagogical activities have a questioning character of the environmental problems. A wide bibliographic review and proposal of pedagogical activities are adopted according to the critical and applicable geographical teaching. The criticism of historical-dialectical materialism guides the discussion of the environmental problem, the teaching of Geography, the role of teachers and the alternative possibilities of didactic activities. Environmental education is discussed, opposing conservative practices with possible didactic alternatives. As results, three pedagogical proposals are presented that permeate curricular contents of Geography teaching for high school, including environmental education. They are suggested to be adaptable to different educational realities, which require the active involvement of teachers and students. It is essential that the discussions and proposals are rendered into effective practices, based on the student’s everyday knowledge.Este trabalho é movido por questões teórico-metodológicas acerca das práticas de educação ambiental, no ensino de Geografia. O objetivo é discutir se tais atividades pedagógicas possuem caráter questionador das problemáticas ambientais. Adota-se revisão bibliográfica ampla e proposição de atividades pedagógicas de acordo com o ensino geográfico crítico e aplicável. A crítica do materialismo histórico-dialético orienta as discussões da problemática ambiental, do ensino de Geografia, do papel dos docentes e das possibilidades alternativas de atividades didáticas. A educação ambiental é discutida contrapondo-se práticas conservadoras com alternativas didáticas possíveis de concretização. Enquanto resultados, apresentam-se três propostas pedagógicas que permeiam conteúdos curriculares do ensino de Geografia para o ensino médio, abarcando a educação ambiental. Elucida-se que são propostas adaptáveis a diferentes realidades educacionais, que necessitam do envolvimento ativo de professores e estudantes. É essencial que as discussões e propostas se traduzam em práticas efetivas, a partir do enfoque nos saberes cotidianos dos estudantes

Constructing Institutional Measures: Indicators of Political and Property Rights in Mozambique, 1900-2005

In this paper we focus on the role of political and economic institutions in Mozambique’s development. We produce a set of institutional indicators for Mozambique for the period 1900 through to 2005. The first index tracks political freedoms and is unique in its duration and complexity. The second index is a measure of property rights for Mozambique and such a measure has not existed previously and certainly not for this length of time. The construction of these indices is a painstaking process through historical records but it provides us with a richness of institutional data previously not available. The new institutional indices will allow us to explore the role of the institutional environment in determining economic growth and development in Mozambique over time.Political Rights, Property Rights, Insitutional Indicators, Mozambique

Analysis of the cooperative action of PRC1 and centralspindlin, the two microtubule bundling factors critical for cytokinesis by advanced live cell imaging

Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2012Citocinése em células animais requer um complexo jogo entre o fuso central pós-metafásico e uma série de proteínas regulatórias e moduladoras da dinâmica microtubular (Douglas and Mishima, 2010). Dois factores essenciais para a formação desta estrutura são a proteína PRC1, capaz de agregar microtúbulos, e o complexo centralspindlin (Jiang et al. 1998; Mishima et al. 2002) – um complexo heterotetramérico composto por duas subunidades diméricas: a proteína motora MKLP1 e a RhoGAP (Rho-family GTPase-activating protein) HsCYK-4. Neste trabalho, exploro como estes factores cooperam e qual a relevância da sua interacão para a divisão celular. Versões nativas ou mutadas de HsCYK-4, fundidas com GFP, foram empregadas para estudar a localização desta proteína e para determinar qual a influência da região C-terminal de HsCYK-4 (a região responsável pela interação com a proteína PRC1; Lee and Mishima, unpublished) na divisão celular. Determinou-se que a acumulação do complexo centralspindlin ocorre em duas fases distintas: 1) uma acumulação pré-ingressão da membrana celular, dependente da região C-terminal de HsCYK-4 e 2) uma acumulação pós-ingressão. Quando a primeira fase foi inibida, via ablação da região Cterminal, observou-se um aumento da proporção de células que falhavam a divisão. Isto ocorria devido a uma falha precoce durante o elongamento celular, ou devido a uma falha tardia devida a perda de integridade do corpo médio. Determinou-se que isto, pelo menos em parte, é causado pela formação de fusos centrais anormais com uma organização microtubular comprometida. Também nestas células foi observado que, apesar do complexo centralspindlin e da proteína PRC1 terem mecanismos de recrutamento independentes, a manutenção da sua localização requer a região de interação no C-terminus de HsCYK-4. Este trabalho dá relevância à interação entre centralspindlin e PRC1, tanto para a sua estável localização como para a manutenção da rigidez do fuso central e do corpo médio durante a divisão celular.Cytokinesis in animal cells requires a complex interplay between the post-metaphase microtubule-based central spindle and several regulatory and microtubule modulating proteins (Douglas and Mishima, 2010). Two protein factors required for the assembly of the central spindle are the microtubule-bundling protein PRC1 and the centralspindlin complex (Jiang et al. 1998; Mishima et al. 2002) – an heterotetramer composed of the motor protein MKLP1 and the RhoGAP (Rho-family GTPase-activating protein) HsCYK-4 subunits. In this work I explore how PRC1 and centralspindlin cooperate and how their interaction leads to a successful cytokinesis. GFP-fused native or mutant versions of the HsCYK-4 protein allowed us to follow centralspindlin localisation and behaviour in vivo, and also determine what influence would the loss of the C-terminal region of HsCYK-4 - the region of PRC1 binding (Lee and Mishima, unpublished) - have on cell division. Centralspindlin accumulation at the middle of the central spindle was found to occur in two stages: a 1) pre-furrow ingression accumulation, heavily dependent on HsCYK-4’s C-terminal region, and a 2) post- furrow ingression accumulation. When the first stage was disrupted, by ablating the C-terminal region of HsCYK-4, an increase in the number of cell division failures was observed. These occurred due to an early failure during elongation of the pole-to-pole distance, or due to a late failure via loss of midbody integrity. This is, in part, caused by the formation of abnormal central spindles with a compromised microtubule organisation. Also, colocalisation between centralspindlin and PRC1 was impaired in these cells, showing that while these molecules have separate targeting mechanisms to the central spindle, the stability of that localisation is dependent on their interacting region. These data point to centralspindlin-PRC1 interaction being essential for the stability of their individual localisation and to maintain the rigidity of the central spindle and midbody during cell division

The “right way” of Hermetism: disputes on Gnostic’s, Pagan’s and Christian’s (re-)visions of the Hermetic phonomenon in late antiquity

This paper aims to understand the phenomenon of Hermetism though the perspective of its process of reception and reproduction in society.It will explore the phenomenon that was the transformation of the Hermetica into a social discourse. The so-called technical and philosophical Hermetica are texts.A text is the result of aproduction: it is composedby men, and addressed tomen. It is important to consider the intentionsand values present in a text’s production, and to understand that its process of reception and reproduction in society are, in fact,complex and dynamic

Not me getting with the times: A new kind of not-fragment in English

In this paper, I describe a relatively new construction in colloquial use by many English speakers: a discourse-initial not-fragment that draws attention to a factual event and conveys some attitude towards it, typically that it is embarrassing, surprising, ironic, ridiculous, or simply bad. A prototypical example of this construction, which I call “spotlight not,” is an utterance like Not me going to Starbucks for the second time today, which is taken to indicate that the speaker is indeed going to Starbucks for the second time that day, and that they find this fact embarrassing or surprising, ironic, etc. Informed by a pilot survey and interviews with speakers who use spotlight not, I discuss the demographics and meaning of this construction, its surface structure and syntactic properties, and some ideas about why it means what it means